MIR4724 (microRNA 4724) - Rat Genome Database

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Gene: MIR4724 (microRNA 4724) Homo sapiens
Analyze
Symbol: MIR4724
Name: microRNA 4724
RGD ID: 5134138
HGNC Page HGNC:41590
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4724
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381731,534,883 - 31,534,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1731,534,883 - 31,534,971 (+)EnsemblGRCh38hg38GRCh38
GRCh371729,861,901 - 29,861,989 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q11.2NCBI
HuRef1726,072,268 - 26,072,356 (+)NCBIHuRef
CHM1_11729,924,510 - 29,924,598 (+)NCBICHM1_1
T2T-CHM13v2.01732,480,645 - 32,480,733 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21199797  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q11.2(chr17:30706864-31999939)x1 copy number loss See cases [RCV000050718] Chr17:30706864..31999939 [GRCh38]
Chr17:29033882..30326958 [GRCh37]
Chr17:26058008..27351071 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:31441351-32005206)x1 copy number loss See cases [RCV000137707] Chr17:31441351..32005206 [GRCh38]
Chr17:29768369..30332225 [GRCh37]
Chr17:26792495..27356338 [NCBI36]
Chr17:17q11.2		 uncertain significance
GRCh38/hg38 17q11.2(chr17:30706845-31999933)x1 copy number loss See cases [RCV000139159] Chr17:30706845..31999933 [GRCh38]
Chr17:29033863..30326952 [GRCh37]
Chr17:26057989..27351065 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30684919-32021402)x1 copy number loss See cases [RCV000140221] Chr17:30684919..32021402 [GRCh38]
Chr17:29011937..30348421 [GRCh37]
Chr17:26036063..27372534 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30666018-32085769)x1 copy number loss See cases [RCV000141687] Chr17:30666018..32085769 [GRCh38]
Chr17:28993036..30412788 [GRCh37]
Chr17:26017162..27436901 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30677603-32071701)x3 copy number gain See cases [RCV000142123] Chr17:30677603..32071701 [GRCh38]
Chr17:29004621..30398720 [GRCh37]
Chr17:26028747..27422833 [NCBI36]
Chr17:17q11.2		 uncertain significance
GRCh38/hg38 17q11.2(chr17:30625268-32059496)x1 copy number loss See cases [RCV000142020] Chr17:30625268..32059496 [GRCh38]
Chr17:28952286..30386515 [GRCh37]
Chr17:25976412..27410628 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:28947825-32490020)x1 copy number loss See cases [RCV000143027] Chr17:28947825..32490020 [GRCh38]
Chr17:27274843..30817038 [GRCh37]
Chr17:24298969..27841151 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30678153-32073866)x1 copy number loss See cases [RCV000143278] Chr17:30678153..32073866 [GRCh38]
Chr17:29005171..30400885 [GRCh37]
Chr17:26029297..27424998 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30706864-31999939)x3 copy number gain See cases [RCV000148149] Chr17:30706864..31999939 [GRCh38]
Chr17:29033882..30326958 [GRCh37]
Chr17:26058008..27351071 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30706864-32099761)x3 copy number gain See cases [RCV000050616] Chr17:30706864..32099761 [GRCh38]
Chr17:29033882..30426780 [GRCh37]
Chr17:26058008..27450893 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30706864-31999939)x3 copy number gain See cases [RCV000050717] Chr17:30706864..31999939 [GRCh38]
Chr17:29033882..30326958 [GRCh37]
Chr17:26058008..27351071 [NCBI36]
Chr17:17q11.2		 pathogenic|uncertain significance|conflicting data from submitters
GRCh38/hg38 17q11.2(chr17:30630734-32088380)x3 copy number gain See cases [RCV000051881] Chr17:30630734..32088380 [GRCh38]
Chr17:28957752..30415399 [GRCh37]
Chr17:25981878..27439512 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30667972-32023858)x3 copy number gain See cases [RCV000051884] Chr17:30667972..32023858 [GRCh38]
Chr17:28994990..30350877 [GRCh37]
Chr17:26019116..27374990 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30613848-31875279)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054360]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054360]|See cases [RCV000054360] Chr17:30613848..31875279 [GRCh38]
Chr17:28940866..30202298 [GRCh37]
Chr17:25964992..27226411 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30672816-31999939)x1 copy number loss See cases [RCV000054361] Chr17:30672816..31999939 [GRCh38]
Chr17:28999834..30326958 [GRCh37]
Chr17:26023960..27351071 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30706863-31994624)x1 copy number loss See cases [RCV000054362] Chr17:30706863..31994624 [GRCh38]
Chr17:29033881..30321643 [GRCh37]
Chr17:26058007..27345756 [NCBI36]
Chr17:17q11.2		 pathogenic
GRCh38/hg38 17q11.2(chr17:30767194-31937486)x1 copy number loss See cases [RCV000054363] Chr17:30767194..31937486 [GRCh38]
Chr17:29094212..30264505 [GRCh37]
Chr17:26118338..27288618 [NCBI36]
Chr17:17q11.2		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:21184
Count of gene targets:9020
Count of transcripts:16863
Interacting mature miRNAs:hsa-miR-4724-3p, hsa-miR-4724-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000579485
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1731,534,883 - 31,534,971 (+)Ensembl
RefSeq Acc Id: NR_039877
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381731,534,883 - 31,534,971 (+)NCBI
GRCh371729,861,901 - 29,861,989 (+)ENTREZGENE
HuRef1726,072,268 - 26,072,356 (+)ENTREZGENE
CHM1_11729,924,510 - 29,924,598 (+)NCBI
T2T-CHM13v2.01732,480,645 - 32,480,733 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4724 COSMIC
Ensembl Genes ENSG00000284424 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000579485 ENTREZGENE
GTEx ENSG00000284424 GTEx
HGNC ID HGNC:41590 ENTREZGENE
Human Proteome Map MIR4724 Human Proteome Map
miRBase MI0017361 ENTREZGENE
NCBI Gene 100616248 ENTREZGENE
RNAcentral URS00003CCBB9 RNACentral
  URS00004C247E RNACentral
  URS000075EEE9 RNACentral