MIR4749 (microRNA 4749) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MIR4749 (microRNA 4749) Homo sapiens
Analyze
Symbol: MIR4749
Name: microRNA 4749
RGD ID: 5134111
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-4749
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1949,854,591 - 49,854,651 (+)EnsemblGRCh38hg38GRCh38
GRCh381949,854,591 - 49,854,651 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,357,848 - 50,357,908 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19q13.33NCBI
HuRef1946,734,189 - 46,734,249 (+)NCBIHuRef
CHM1_11950,359,684 - 50,359,744 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21199797   PMID:28798470  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:79615
Count of gene targets:22046
Count of transcripts:60236
Interacting mature miRNAs:hsa-miR-4749-3p, hsa-miR-4749-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1
Low 164 150 230 28 76 12 279 93 447 15 259 165 16 87 199
Below cutoff 42 42 26 9 28 4 52 55 117 9 26 16 5 9 38 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000578197
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1949,854,591 - 49,854,651 (+)Ensembl
RefSeq Acc Id: NR_039904
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,854,591 - 49,854,651 (+)NCBI
GRCh371950,357,848 - 50,357,908 (+)NCBI
HuRef1946,734,189 - 46,734,249 (+)NCBI
CHM1_11950,359,684 - 50,359,744 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4749 COSMIC
Ensembl Genes ENSG00000265954 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578197 ENTREZGENE
GTEx ENSG00000265954 GTEx
HGNC ID HGNC:41760 ENTREZGENE
Human Proteome Map MIR4749 Human Proteome Map
miRBase MI0017388 ENTREZGENE
NCBI Gene 100616313 ENTREZGENE
RNAcentral URS0000077DDE RNACentral
  URS00000CDD4F RNACentral
  URS000075D57A RNACentral