MIR4781 (microRNA 4781) - Rat Genome Database

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Gene: MIR4781 (microRNA 4781) Homo sapiens
Analyze
Symbol: MIR4781
Name: microRNA 4781
RGD ID: 5134107
HGNC Page HGNC:41769
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4781
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38154,054,079 - 54,054,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl154,054,079 - 54,054,154 (+)EnsemblGRCh38hg38GRCh38
GRCh37154,519,752 - 54,519,827 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p32.3NCBI
CHM1_1154,636,077 - 54,636,152 (+)NCBICHM1_1
T2T-CHM13v2.0153,936,982 - 53,937,057 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21199797  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_004872.4(TMEM59):c.16G>A (p.Gly6Arg) single nucleotide variant Malignant melanoma [RCV000064822] Chr1:54053173 [GRCh38]
Chr1:54518846 [GRCh37]
Chr1:54291434 [NCBI36]
Chr1:1p32.3		 not provided
GRCh38/hg38 1p32.3-31.3(chr1:53627272-64248854)x1 copy number loss See cases [RCV000139470] Chr1:53627272..64248854 [GRCh38]
Chr1:54092945..64714537 [GRCh37]
Chr1:53865533..64487125 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:52787503-67339873)x3 copy number gain See cases [RCV000141758] Chr1:52787503..67339873 [GRCh38]
Chr1:53253175..67805556 [GRCh37]
Chr1:53025763..67578144 [NCBI36]
Chr1:1p32.3-31.3		 likely pathogenic
GRCh38/hg38 1p32.3(chr1:53823735-54328113)x3 copy number gain See cases [RCV000142034] Chr1:53823735..54328113 [GRCh38]
Chr1:54289408..54793786 [GRCh37]
Chr1:54061996..54566374 [NCBI36]
Chr1:1p32.3		 uncertain significance
GRCh38/hg38 1p32.3-31.3(chr1:50222546-61618373)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|See cases [RCV000051819] Chr1:50222546..61618373 [GRCh38]
Chr1:50688218..62084045 [GRCh37]
Chr1:50460805..61856633 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic
GRCh38/hg38 1p32.3-31.1(chr1:52595352-76767765)x3 copy number gain See cases [RCV000051822] Chr1:52595352..76767765 [GRCh38]
Chr1:53061024..77233450 [GRCh37]
Chr1:52833612..77006038 [NCBI36]
Chr1:1p32.3-31.1		 pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:53738212-61439648)x1 copy number loss See cases [RCV000053839] Chr1:53738212..61439648 [GRCh38]
Chr1:54203885..61905320 [GRCh37]
Chr1:53976473..61677908 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:43538
Count of gene targets:16818
Count of transcripts:38054
Interacting mature miRNAs:hsa-miR-4781-3p, hsa-miR-4781-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 6 4 5 1 5 9 4 4 11 4 1 3 6
Below cutoff 1 3 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000585250
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl154,054,079 - 54,054,154 (+)Ensembl
RefSeq Acc Id: NR_039942
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,054,079 - 54,054,154 (+)NCBI
GRCh37154,519,752 - 54,519,827 (+)ENTREZGENE
CHM1_1154,636,077 - 54,636,152 (+)NCBI
T2T-CHM13v2.0153,936,982 - 53,937,057 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4781 COSMIC
Ensembl Genes ENSG00000283749 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000585250 ENTREZGENE
GTEx ENSG00000283749 GTEx
HGNC ID HGNC:41769 ENTREZGENE
Human Proteome Map MIR4781 Human Proteome Map
miRBase MI0017426 ENTREZGENE
NCBI Gene 100616315 ENTREZGENE
RNAcentral URS00000913AC RNACentral
  URS0000128A0A RNACentral
  URS000075CD27 RNACentral