MIR4716 (microRNA 4716) - Rat Genome Database

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Gene: MIR4716 (microRNA 4716) Homo sapiens
Analyze
Symbol: MIR4716
Name: microRNA 4716
RGD ID: 5134101
HGNC Page HGNC:41812
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4716
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381549,169,070 - 49,169,153 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1549,169,070 - 49,169,153 (-)EnsemblGRCh38hg38GRCh38
GRCh371549,461,267 - 49,461,350 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map15q21.1NCBI
HuRef1526,293,336 - 26,293,419 (-)NCBIHuRef
CHM1_11549,579,561 - 49,579,644 (-)NCBICHM1_1
T2T-CHM13v2.01546,977,278 - 46,977,361 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21199797  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q21.1-21.2(chr15:47460844-52494222)x1 copy number loss See cases [RCV000135639] Chr15:47460844..52494222 [GRCh38]
Chr15:47753041..52786419 [GRCh37]
Chr15:45540333..50573711 [NCBI36]
Chr15:15q21.1-21.2		 pathogenic
GRCh38/hg38 15q21.1-21.2(chr15:49064333-50176783)x1 copy number loss See cases [RCV000137613] Chr15:49064333..50176783 [GRCh38]
Chr15:49356530..50468980 [GRCh37]
Chr15:47143822..48256272 [NCBI36]
Chr15:15q21.1-21.2		 uncertain significance
GRCh38/hg38 15q21.1-21.3(chr15:46042302-54195828)x1 copy number loss See cases [RCV000051619] Chr15:46042302..54195828 [GRCh38]
Chr15:46334500..54488025 [GRCh37]
Chr15:44121792..52275317 [NCBI36]
Chr15:15q21.1-21.3		 pathogenic
GRCh38/hg38 15q21.1-21.3(chr15:48695331-53923002)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]|See cases [RCV000051620] Chr15:48695331..53923002 [GRCh38]
Chr15:48987528..54215199 [GRCh37]
Chr15:46774820..52002491 [NCBI36]
Chr15:15q21.1-21.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:74812
Count of gene targets:22722
Count of transcripts:56546
Interacting mature miRNAs:hsa-miR-4716-3p, hsa-miR-4716-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 9 6 7 3 18 3 9 2 15 6 17 11 1 1 6 1
Below cutoff 5 6 5 1 15 2 8 6 13 3 7 4 2 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000579628
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1549,169,070 - 49,169,153 (-)Ensembl
RefSeq Acc Id: NR_039866
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381549,169,070 - 49,169,153 (-)NCBI
GRCh371549,461,267 - 49,461,350 (-)ENTREZGENE
HuRef1526,293,336 - 26,293,419 (-)ENTREZGENE
CHM1_11549,579,561 - 49,579,644 (-)NCBI
T2T-CHM13v2.01546,977,278 - 46,977,361 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4716 COSMIC
Ensembl Genes ENSG00000264210 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000579628 ENTREZGENE
GTEx ENSG00000264210 GTEx
HGNC ID HGNC:41812 ENTREZGENE
Human Proteome Map MIR4716 Human Proteome Map
miRBase MI0017350 ENTREZGENE
NCBI Gene 100616332 ENTREZGENE
RNAcentral URS000020579D RNACentral
  URS00002DA7E9 RNACentral
  URS000075BB93 RNACentral