MIR4774 (microRNA 4774) - Rat Genome Database
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Gene: MIR4774 (microRNA 4774) Homo sapiens
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Symbol: MIR4774
Name: microRNA 4774
RGD ID: 5134088
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2168,582,943 - 168,583,018 (+)EnsemblGRCh38hg38GRCh38
GRCh382168,582,943 - 168,583,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372169,439,453 - 169,439,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map2q24.3NCBI
HuRef2161,318,546 - 161,318,621 (+)NCBIHuRef
CHM1_12169,445,366 - 169,445,441 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21199797   PMID:21606961  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:19481
Count of gene targets:8113
Count of transcripts:14915
Interacting mature miRNAs:hsa-miR-4774-3p, hsa-miR-4774-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 3 7 1 1
Low 23 7 15 8 75 9 22 11 25 10 29 26 4
Below cutoff 16 2 4 1 10 2 11 11 12 8 8 14 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_039933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC019086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000583305
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2168,582,943 - 168,583,018 (+)Ensembl
RefSeq Acc Id: NR_039933
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382168,582,943 - 168,583,018 (+)NCBI
GRCh372169,439,453 - 169,439,528 (+)ENTREZGENE
HuRef2161,318,546 - 161,318,621 (+)ENTREZGENE
CHM1_12169,445,366 - 169,445,441 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q24.1-31.1(chr2:154294042-175989372)x3 copy number gain See cases [RCV000142286] Chr2:154294042..175989372 [GRCh38]
Chr2:155150555..176854100 [GRCh37]
Chr2:154858801..176562346 [NCBI36]
Chr2:2q24.1-31.1
pathogenic
GRCh38/hg38 2q24.3(chr2:167995450-168840081)x3 copy number gain See cases [RCV000142874] Chr2:167995450..168840081 [GRCh38]
Chr2:168851960..169696591 [GRCh37]
Chr2:168560206..169404837 [NCBI36]
Chr2:2q24.3
likely benign
GRCh38/hg38 2q24.3-31.1(chr2:164850117-175559190)x1 copy number loss See cases [RCV000051201] Chr2:164850117..175559190 [GRCh38]
Chr2:165706627..176423918 [GRCh37]
Chr2:165414873..176132164 [NCBI36]
Chr2:2q24.3-31.1
pathogenic
GRCh38/hg38 2q24.3-32.1(chr2:163965382-182195062)x1 copy number loss See cases [RCV000054122] Chr2:163965382..182195062 [GRCh38]
Chr2:164821892..183059789 [GRCh37]
Chr2:164530138..182768034 [NCBI36]
Chr2:2q24.3-32.1
pathogenic
GRCh38/hg38 2q24.3-31.1(chr2:164066038-172097886)x1 copy number loss See cases [RCV000054123] Chr2:164066038..172097886 [GRCh38]
Chr2:164922548..172962614 [GRCh37]
Chr2:164630794..172670860 [NCBI36]
Chr2:2q24.3-31.1
pathogenic
GRCh38/hg38 2q24.3-31.1(chr2:165209651-169567892)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054124]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054124]|See cases [RCV000054124] Chr2:165209651..169567892 [GRCh38]
Chr2:166066161..170424402 [GRCh37]
Chr2:165774407..170132648 [NCBI36]
Chr2:2q24.3-31.1
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4774 COSMIC
Ensembl Genes ENSG00000265694 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000583305 ENTREZGENE
GTEx ENSG00000265694 GTEx
HGNC ID HGNC:41873 ENTREZGENE
Human Proteome Map MIR4774 Human Proteome Map
miRBase MI0017417 ENTREZGENE
NCBI Gene 100616356 ENTREZGENE
RNAcentral URS0000495FF7 RNACentral
  URS000055153D RNACentral
  URS000075A2B9 RNACentral