MIR4730 (microRNA 4730) - Rat Genome Database
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Gene: MIR4730 (microRNA 4730) Homo sapiens
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Symbol: MIR4730
Name: microRNA 4730
RGD ID: 5134084
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1780,419,418 - 80,419,493 (+)EnsemblGRCh38hg38GRCh38
GRCh381780,419,418 - 80,419,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371778,393,218 - 78,393,293 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q25.3NCBI
HuRef1773,831,212 - 73,831,287 (+)NCBIHuRef
CHM1_11778,479,465 - 78,479,540 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
1. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:21199797  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:17115
Count of gene targets:9150
Count of transcripts:16110
Interacting mature miRNAs:hsa-miR-4730
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 1 12 1 1 6 2 2 3 1
Low 184 55 233 125 309 119 269 85 242 181 255 317 15 31 82 3
Below cutoff 58 37 34 7 29 3 67 42 84 14 24 28 4 23 39 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_039883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000584535
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1780,419,418 - 80,419,493 (+)Ensembl
RefSeq Acc Id: NR_039883
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381780,419,418 - 80,419,493 (+)NCBI
GRCh371778,393,218 - 78,393,293 (+)ENTREZGENE
HuRef1773,831,212 - 73,831,287 (+)ENTREZGENE
CHM1_11778,479,465 - 78,479,540 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_173627.4(ENDOV):c.267C>T (p.Ala89=) single nucleotide variant Malignant melanoma [RCV000071706] Chr17:80421866 [GRCh38]
Chr17:78395666 [GRCh37]
Chr17:76010261 [NCBI36]
Chr17:17q25.3
not provided
GRCh38/hg38 17q25.3(chr17:80328106-80955527)x1 copy number loss See cases [RCV000140286] Chr17:80328106..80955527 [GRCh38]
Chr17:78301906..78929327 [GRCh37]
Chr17:75916501..76543922 [NCBI36]
Chr17:17q25.3
uncertain significance
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78092236-83086677)x3 copy number gain See cases [RCV000050685] Chr17:78092236..83086677 [GRCh38]
Chr17:76088317..81044553 [GRCh37]
Chr17:73599912..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78901959-83086677)x3 copy number gain See cases [RCV000050934] Chr17:78901959..83086677 [GRCh38]
Chr17:76898041..81044553 [GRCh37]
Chr17:74409636..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78918650-83021095)x3 copy number gain See cases [RCV000052497] Chr17:78918650..83021095 [GRCh38]
Chr17:76914732..80978971 [GRCh37]
Chr17:74426327..78572260 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:80328106-83086677)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053454]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053454]|See cases [RCV000053454] Chr17:80328106..83086677 [GRCh38]
Chr17:78301906..81044553 [GRCh37]
Chr17:75916501..78637842 [NCBI36]
Chr17:17q25.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4730 COSMIC
Ensembl Genes ENSG00000264961 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000584535 ENTREZGENE
GTEx ENSG00000264961 GTEx
HGNC ID HGNC:41880 ENTREZGENE
Human Proteome Map MIR4730 Human Proteome Map
miRBase MI0017367 ENTREZGENE
NCBI Gene 100616359 ENTREZGENE
RNAcentral URS00002E4C79 RNACentral
  URS000075CB67 RNACentral