MIR4692 (microRNA 4692) - Rat Genome Database

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Gene: MIR4692 (microRNA 4692) Homo sapiens
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Symbol: MIR4692
Name: microRNA 4692
RGD ID: 5134053
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,783,530 - 72,783,592 (+)EnsemblGRCh38hg38GRCh38
GRCh381172,783,530 - 72,783,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,494,575 - 72,494,637 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11q13.4NCBI
HuRef1168,789,718 - 68,789,780 (+)NCBIHuRef
CHM1_11172,377,884 - 72,377,946 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21199797  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:39800
Count of gene targets:14276
Count of transcripts:31266
Interacting mature miRNAs:hsa-miR-4692
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1
Low 53 3 76 67 47 70 10 2 7 15 32 36 3 2
Below cutoff 13 1 4 1 4 1 7 5 6 2 4 9 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_039841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AP002381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000583200
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,783,530 - 72,783,592 (+)Ensembl
RefSeq Acc Id: NR_039841
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,783,530 - 72,783,592 (+)NCBI
GRCh371172,494,575 - 72,494,637 (+)ENTREZGENE
HuRef1168,789,718 - 68,789,780 (+)ENTREZGENE
CHM1_11172,377,884 - 72,377,946 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5
pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4692 COSMIC
Ensembl Genes ENSG00000265064 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000583200 ENTREZGENE
GTEx ENSG00000265064 GTEx
HGNC ID HGNC:41856 ENTREZGENE
Human Proteome Map MIR4692 Human Proteome Map
miRBase MI0017325 ENTREZGENE
NCBI Gene 100616410 ENTREZGENE
RNAcentral URS000036BD40 RNACentral
  URS000075C1CE RNACentral