MIR4421 (microRNA 4421) - Rat Genome Database
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Pathways
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Gene: MIR4421 (microRNA 4421) Homo sapiens
Analyze
Symbol: MIR4421
Name: microRNA 4421
RGD ID: 5133985
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl151,059,837 - 51,059,905 (+)EnsemblGRCh38hg38GRCh38
GRCh38151,059,837 - 51,059,905 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37151,525,509 - 51,525,577 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p32.3NCBI
HuRef149,643,038 - 49,643,106 (+)NCBIHuRef
CHM1_1151,643,075 - 51,643,143 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
paraquat  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:29630094  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:27075
Count of gene targets:12023
Count of transcripts:22984
Interacting mature miRNAs:hsa-miR-4421
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue
High
Medium
Low 7 2 28 15 78 15 11 14 42 59 41 57 1 1
Below cutoff 5 1 10 2 10 8 6 4 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_039617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL590455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000578133
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl151,059,837 - 51,059,905 (+)Ensembl
RefSeq Acc Id: NR_039617
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38151,059,837 - 51,059,905 (+)NCBI
GRCh37151,525,509 - 51,525,577 (+)ENTREZGENE
HuRef149,643,038 - 49,643,106 (+)ENTREZGENE
CHM1_1151,643,075 - 51,643,143 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p33-32.3(chr1:49807460-51412851)x3 copy number gain See cases [RCV000141757] Chr1:49807460..51412851 [GRCh38]
Chr1:50273132..51878523 [GRCh37]
Chr1:50045719..51651111 [NCBI36]
Chr1:1p33-32.3		 uncertain significance
GRCh38/hg38 1p32.3(chr1:50462649-51149312)x3 copy number gain See cases [RCV000050731] Chr1:50462649..51149312 [GRCh38]
Chr1:50928321..51614984 [GRCh37]
Chr1:50700909..51387572 [NCBI36]
Chr1:1p32.3		 uncertain significance
GRCh38/hg38 1p32.3-31.3(chr1:50222546-61618373)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|See cases [RCV000051819] Chr1:50222546..61618373 [GRCh38]
Chr1:50688218..62084045 [GRCh37]
Chr1:50460805..61856633 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4421 COSMIC
Ensembl Genes ENSG00000265538 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578133 ENTREZGENE
GTEx ENSG00000265538 GTEx
HGNC ID HGNC:41879 ENTREZGENE
Human Proteome Map MIR4421 Human Proteome Map
miRBase MI0016758 ENTREZGENE
NCBI Gene 100616189 ENTREZGENE
RNAcentral URS00002B0920 RNACentral
  URS000075E47B RNACentral