MIR4496 (microRNA 4496) - Rat Genome Database

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Gene: MIR4496 (microRNA 4496) Homo sapiens
Analyze
Symbol: MIR4496
Name: microRNA 4496
RGD ID: 5133964
HGNC Page HGNC:41569
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,635,810 - 108,635,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,635,810 - 108,635,870 (+)EnsemblGRCh38hg38GRCh38
GRCh3712109,029,586 - 109,029,646 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12q24.11NCBI
HuRef12106,093,956 - 106,094,016 (+)NCBIHuRef
CHM1_112108,996,331 - 108,996,391 (+)NCBICHM1_1
T2T-CHM13v2.012108,610,405 - 108,610,465 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:28008607   PMID:30177389   PMID:33375517  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.3-24.11(chr12:105644967-108994840)x1 copy number loss See cases [RCV000138537] Chr12:105644967..108994840 [GRCh38]
Chr12:106038745..109432645 [GRCh37]
Chr12:104562875..107917026 [NCBI36]
Chr12:12q23.3-24.11		 uncertain significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11		 pathogenic
GRCh38/hg38 12q23.3-24.13(chr12:105234677-112194686)x1 copy number loss See cases [RCV000050807] Chr12:105234677..112194686 [GRCh38]
Chr12:105628455..112632490 [GRCh37]
Chr12:104152585..111116873 [NCBI36]
Chr12:12q23.3-24.13		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:22571
Count of gene targets:8764
Count of transcripts:16739
Interacting mature miRNAs:hsa-miR-4496
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 4 3 1 18 1 4 3 2 3 3 3
Below cutoff 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000635896
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12108,635,810 - 108,635,870 (+)Ensembl
RefSeq Acc Id: NR_039717
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812108,635,810 - 108,635,870 (+)NCBI
GRCh3712109,029,586 - 109,029,646 (+)ENTREZGENE
HuRef12106,093,956 - 106,094,016 (+)ENTREZGENE
CHM1_112108,996,331 - 108,996,391 (+)NCBI
T2T-CHM13v2.012108,610,405 - 108,610,465 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4496 COSMIC
Ensembl Genes ENSG00000284388 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000635896 ENTREZGENE
GTEx ENSG00000284388 GTEx
HGNC ID HGNC:41569 ENTREZGENE
Human Proteome Map MIR4496 Human Proteome Map
miRBase MI0016858 ENTREZGENE
NCBI Gene 100616240 ENTREZGENE
RNAcentral URS000056B180 RNACentral
  URS000075E084 RNACentral