MIR4485 (microRNA 4485) - Rat Genome Database

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Gene: MIR4485 (microRNA 4485) Homo sapiens
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Symbol: MIR4485
Name: microRNA 4485
RGD ID: 5133959
HGNC Page HGNC:41628
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4485
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,508,270 - 10,508,326 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,508,270 - 10,508,326 (-)EnsemblGRCh38hg38GRCh38
GRCh371110,529,817 - 10,529,873 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11p15.4NCBI
CHM1_11110,527,864 - 10,527,920 (-)NCBICHM1_1
T2T-CHM13v2.01110,592,745 - 10,592,801 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21037258   PMID:25201637   PMID:28220193   PMID:32030798   PMID:33867845  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.4-15.2(chr11:9989516-16825806)x1 copy number loss See cases [RCV000136773] Chr11:9989516..16825806 [GRCh38]
Chr11:10011063..16847353 [GRCh37]
Chr11:9967639..16803929 [NCBI36]
Chr11:11p15.4-15.2
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:11085
Count of gene targets:6787
Count of transcripts:10994
Interacting mature miRNAs:hsa-miR-4485
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


RefSeq Acc Id: ENST00000638094
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1110,508,270 - 10,508,326 (-)Ensembl
RefSeq Acc Id: NR_039705
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381110,508,270 - 10,508,326 (-)NCBI
GRCh371110,529,817 - 10,529,873 (-)ENTREZGENE
CHM1_11110,527,864 - 10,527,920 (-)NCBI
T2T-CHM13v2.01110,592,745 - 10,592,801 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4485 COSMIC
Ensembl Genes ENSG00000283813 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000638094 ENTREZGENE
GTEx ENSG00000283813 GTEx
HGNC ID HGNC:41628 ENTREZGENE
Human Proteome Map MIR4485 Human Proteome Map
miRBase MI0016846 ENTREZGENE
NCBI Gene 100616263 ENTREZGENE
RNAcentral URS000038446A RNACentral
  URS000075CEC3 RNACentral
  URS00007649C8 RNACentral