MIR4433A (microRNA 4433a) - Rat Genome Database
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Gene: MIR4433A (microRNA 4433a) Homo sapiens
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Symbol: MIR4433A
Name: microRNA 4433a
RGD ID: 5133953
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-4433a; MIR4433
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl264,340,759 - 64,340,839 (+)EnsemblGRCh38hg38GRCh38
GRCh38264,340,759 - 64,340,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37264,567,893 - 64,567,973 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map2p14NCBI
HuRef264,302,778 - 64,302,858 (+)NCBIHuRef
CHM1_1264,498,508 - 64,498,588 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21558790   PMID:31926946  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:50969
Count of gene targets:16394
Count of transcripts:37927
Interacting mature miRNAs:hsa-miR-4433-3p, hsa-miR-4433-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_039632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000637652
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl264,340,759 - 64,340,839 (+)Ensembl
RefSeq Acc Id: NR_039632
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38264,340,759 - 64,340,839 (+)NCBI
GRCh37264,567,893 - 64,567,973 (+)ENTREZGENE
HuRef264,302,778 - 64,302,858 (+)ENTREZGENE
CHM1_1264,498,508 - 64,498,588 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2
pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2
uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh38/hg38 2p15-14(chr2:63311999-67309291)x1 copy number loss See cases [RCV000054054] Chr2:63311999..67309291 [GRCh38]
Chr2:63539134..67536423 [GRCh37]
Chr2:63392638..67389927 [NCBI36]
Chr2:2p15-14
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4433A COSMIC
Ensembl Genes ENSG00000283222 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000637652 ENTREZGENE
GTEx ENSG00000283222 GTEx
HGNC ID HGNC:41634 ENTREZGENE
Human Proteome Map MIR4433A Human Proteome Map
miRBase MI0016773 ENTREZGENE
NCBI Gene 100616265 ENTREZGENE
RNAcentral URS00005A3BC9 RNACentral
  URS000075A620 RNACentral
  URS000075C7DE RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 MIR4433A  microRNA 4433a  MIR4433  microRNA 4433  Symbol and/or name change 5135510 APPROVED
2011-09-01 MIR4433  microRNA 4433  MIR4433  microRNA 4433  Symbol and/or name change 5135510 APPROVED