MIR4481 (microRNA 4481) - Rat Genome Database

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Gene: MIR4481 (microRNA 4481) Homo sapiens
Analyze
Symbol: MIR4481
Name: microRNA 4481
RGD ID: 5133939
HGNC Page HGNC:41781
Description: Located in extracellular vesicle.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381012,653,138 - 12,653,197 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1012,653,138 - 12,653,197 (-)EnsemblGRCh38hg38GRCh38
GRCh371012,695,137 - 12,695,196 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map10p13NCBI
HuRef1012,608,326 - 12,608,385 (-)NCBIHuRef
CHM1_11012,695,288 - 12,695,347 (-)NCBICHM1_1
T2T-CHM13v2.01012,666,157 - 12,666,216 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:28798470  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10p13(chr10:12333253-13948472)x1 copy number loss See cases [RCV000134396] Chr10:12333253..13948472 [GRCh38]
Chr10:12375252..13990472 [GRCh37]
Chr10:12415258..14030478 [NCBI36]
Chr10:10p13		 likely pathogenic
GRCh38/hg38 10p15.3-13(chr10:73856-12815915)x3 copy number gain See cases [RCV000135340] Chr10:73856..12815915 [GRCh38]
Chr10:119796..12857914 [GRCh37]
Chr10:109796..12897920 [NCBI36]
Chr10:10p15.3-13		 pathogenic
GRCh38/hg38 10p14-12.31(chr10:7428770-21587752)x1 copy number loss See cases [RCV000137307] Chr10:7428770..21587752 [GRCh38]
Chr10:7470732..21876681 [GRCh37]
Chr10:7510738..21916687 [NCBI36]
Chr10:10p14-12.31		 pathogenic|uncertain significance
GRCh38/hg38 10p15.3-13(chr10:70478-15373336)x3 copy number gain See cases [RCV000137384] Chr10:70478..15373336 [GRCh38]
Chr10:224406..15415335 [GRCh37]
Chr10:106418..15455341 [NCBI36]
Chr10:10p15.3-13		 uncertain significance
GRCh38/hg38 10p15.3-12.1(chr10:90205-26339978)x3 copy number gain See cases [RCV000138428] Chr10:90205..26339978 [GRCh38]
Chr10:224406..26628907 [GRCh37]
Chr10:126145..26668913 [NCBI36]
Chr10:10p15.3-12.1		 pathogenic
GRCh38/hg38 10p15.3-13(chr10:70478-13736564)x1 copy number loss See cases [RCV000138960] Chr10:70478..13736564 [GRCh38]
Chr10:224406..13778564 [GRCh37]
Chr10:106418..13818570 [NCBI36]
Chr10:10p15.3-13		 pathogenic
GRCh38/hg38 10p15.1-q11.22(chr10:4604734-48074662)x3 copy number gain See cases [RCV000141497] Chr10:4604734..48074662 [GRCh38]
Chr10:4646926..47531169 [GRCh37]
Chr10:4636926..47125152 [NCBI36]
Chr10:10p15.1-q11.22		 benign
GRCh38/hg38 10p15.3-13(chr10:54086-13205916)x3 copy number gain See cases [RCV000142292] Chr10:54086..13205916 [GRCh38]
Chr10:100026..13247916 [GRCh37]
Chr10:90026..13287922 [NCBI36]
Chr10:10p15.3-13		 pathogenic
GRCh38/hg38 10p15.3-12.31(chr10:54086-19336980)x1 copy number loss See cases [RCV000143703] Chr10:54086..19336980 [GRCh38]
Chr10:100026..19625909 [GRCh37]
Chr10:90026..19665915 [NCBI36]
Chr10:10p15.3-12.31		 pathogenic|likely pathogenic
GRCh38/hg38 10p13(chr10:12377967-12692594)x3 copy number gain See cases [RCV000051595] Chr10:12377967..12692594 [GRCh38]
Chr10:12419966..12734593 [GRCh37]
Chr10:12459972..12774599 [NCBI36]
Chr10:10p13		 uncertain significance
GRCh38/hg38 10p15.3-13(chr10:90421-15569528)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052496]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052496]|See cases [RCV000052496] Chr10:90421..15569528 [GRCh38]
Chr10:224406..15611527 [GRCh37]
Chr10:126361..15651533 [NCBI36]
Chr10:10p15.3-13		 pathogenic
GRCh38/hg38 10p15.1-13(chr10:4802753-16823491)x1 copy number loss See cases [RCV000052500] Chr10:4802753..16823491 [GRCh38]
Chr10:4844945..16865490 [GRCh37]
Chr10:4834945..16905496 [NCBI36]
Chr10:10p15.1-13		 pathogenic
GRCh38/hg38 10p15.3-12.31(chr10:69261-19184047)x3 copy number gain See cases [RCV000053507] Chr10:69261..19184047 [GRCh38]
Chr10:224406..19472976 [GRCh37]
Chr10:105201..19512982 [NCBI36]
Chr10:10p15.3-12.31		 pathogenic
GRCh38/hg38 10p15.3-12.2(chr10:90221-22567425)x3 copy number gain See cases [RCV000053508] Chr10:90221..22567425 [GRCh38]
Chr10:224406..22856354 [GRCh37]
Chr10:126161..22896360 [NCBI36]
Chr10:10p15.3-12.2		 pathogenic
GRCh38/hg38 10p15.3-12.1(chr10:90421-29058318)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|See cases [RCV000053512] Chr10:90421..29058318 [GRCh38]
Chr10:224406..29347247 [GRCh37]
Chr10:126361..29387253 [NCBI36]
Chr10:10p15.3-12.1		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:25597
Count of gene targets:10969
Count of transcripts:21032
Interacting mature miRNAs:hsa-miR-4481
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system appendage
High
Medium 4
Low 1 3 26 2 3 4 2
Below cutoff 4 2 2 2 2 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000637781
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1012,653,138 - 12,653,197 (-)Ensembl
RefSeq Acc Id: NR_039701
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381012,653,138 - 12,653,197 (-)NCBI
GRCh371012,695,137 - 12,695,196 (-)ENTREZGENE
HuRef1012,608,326 - 12,608,385 (-)ENTREZGENE
CHM1_11012,695,288 - 12,695,347 (-)NCBI
T2T-CHM13v2.01012,666,157 - 12,666,216 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4481 COSMIC
Ensembl Genes ENSG00000283699 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000637781 ENTREZGENE
GTEx ENSG00000283699 GTEx
HGNC ID HGNC:41781 ENTREZGENE
Human Proteome Map MIR4481 Human Proteome Map
miRBase MI0016842 ENTREZGENE
NCBI Gene 100616320 ENTREZGENE
PharmGKB PA166176233 PharmGKB
RNAcentral URS0000759B99 RNACentral
  URS000075BEB1 RNACentral