MIR4482 (microRNA 4482) - Rat Genome Database

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Gene: MIR4482 (microRNA 4482) Homo sapiens
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Symbol: MIR4482
Name: microRNA 4482
RGD ID: 5133936
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-4482-1; MIR4482-1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10104,268,336 - 104,268,405 (-)EnsemblGRCh38hg38GRCh38
GRCh3810104,268,336 - 104,268,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710106,028,094 - 106,028,163 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map10q25.1NCBI
HuRef1099,659,874 - 99,659,943 (-)NCBIHuRef
CHM1_110106,311,980 - 106,312,049 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21558790   PMID:21785231  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:44886
Count of gene targets:16764
Count of transcripts:35159
Interacting mature miRNAs:hsa-miR-4482-3p, hsa-miR-4482-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 42 7 41 36 182 38 112 19 32 11 53 84 5 1
Low 138 19 206 150 378 152 180 41 141 230 225 247 3 3 7 3
Below cutoff 3 5 9 2 2 13 6 12 6 5 11 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000583050
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10104,268,336 - 104,268,405 (-)Ensembl
RefSeq Acc Id: NR_039702
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,268,336 - 104,268,405 (-)NCBI
GRCh3710106,028,094 - 106,028,163 (-)ENTREZGENE
HuRef1099,659,874 - 99,659,943 (-)ENTREZGENE
CHM1_110106,311,980 - 106,312,049 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.1(chr10:104077161-108350985)x3 copy number gain See cases [RCV000138300] Chr10:104077161..108350985 [GRCh38]
Chr10:105836919..110110743 [GRCh37]
Chr10:105826909..110100733 [NCBI36]
Chr10:10q25.1
uncertain significance
GRCh38/hg38 10q24.32-25.3(chr10:102732173-114085105)x1 copy number loss See cases [RCV000143371] Chr10:102732173..114085105 [GRCh38]
Chr10:104491930..115844864 [GRCh37]
Chr10:104481920..115834854 [NCBI36]
Chr10:10q24.32-25.3
pathogenic
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4482 COSMIC
Ensembl Genes ENSG00000266852 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000583050 ENTREZGENE
GTEx ENSG00000266852 GTEx
HGNC ID HGNC:41792 ENTREZGENE
Human Proteome Map MIR4482 Human Proteome Map
miRBase MI0016843 ENTREZGENE
NCBI Gene 100616323 ENTREZGENE
RNAcentral URS000075A962 RNACentral
  URS000075E237 RNACentral
  URS000075F0D2 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-26 MIR4482  microRNA 4482  MIR4482-1  microRNA 4482-1  Symbol and/or name change 5135510 APPROVED
2011-11-22 MIR4482-1  microRNA 4482-1  MIR4482  microRNA 4482  Symbol and/or name change 5135510 APPROVED
2011-09-01 MIR4482  microRNA 4482  MIR4482  microRNA 4482  Symbol and/or name change 5135510 APPROVED