MIR4518 (microRNA 4518) - Rat Genome Database

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Gene: MIR4518 (microRNA 4518) Homo sapiens
Analyze
Symbol: MIR4518
Name: microRNA 4518
RGD ID: 5133909
HGNC Page HGNC:41809
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4518
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,503,919 - 30,504,001 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,503,919 - 30,504,001 (+)EnsemblGRCh38hg38GRCh38
GRCh371630,515,240 - 30,515,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map16p11.2NCBI
HuRef1628,077,923 - 28,078,005 (+)NCBIHuRef
CHM1_11631,832,426 - 31,832,508 (+)NCBICHM1_1
T2T-CHM13v2.01630,890,905 - 30,890,987 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21037258  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p11.2(chr16:29909613-31438697)x3 copy number gain See cases [RCV000135339] Chr16:29909613..31438697 [GRCh38]
Chr16:29920934..31450018 [GRCh37]
Chr16:29828435..31357519 [NCBI36]
Chr16:16p11.2		 pathogenic
GRCh38/hg38 16p11.2(chr16:29581462-30691912)x1 copy number loss See cases [RCV000135589] Chr16:29581462..30691912 [GRCh38]
Chr16:29592783..30703233 [GRCh37]
Chr16:29500284..30610734 [NCBI36]
Chr16:16p11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:27311746-31193406)x3 copy number gain See cases [RCV000140341] Chr16:27311746..31193406 [GRCh38]
Chr16:27323067..31204727 [GRCh37]
Chr16:27230568..31112228 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23752047-31943755)x3 copy number gain See cases [RCV000141141] Chr16:23752047..31943755 [GRCh38]
Chr16:23763368..31955076 [GRCh37]
Chr16:23670869..31862577 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23047969-30632245)x3 copy number gain See cases [RCV000052401] Chr16:23047969..30632245 [GRCh38]
Chr16:23059290..30643566 [GRCh37]
Chr16:22966791..30551067 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh38/hg38 16p11.2(chr16:30359229-30570499)x3 copy number gain See cases [RCV000053863] Chr16:30359229..30570499 [GRCh38]
Chr16:30370550..30581820 [GRCh37]
Chr16:30278051..30489321 [NCBI36]
Chr16:16p11.2		 uncertain significance
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:43772
Count of gene targets:14981
Count of transcripts:32936
Interacting mature miRNAs:hsa-miR-4518
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium 3 17 1
Low 30 52 30 18 266 18 34 16 27 24 38 34 8 26
Below cutoff 28 65 12 3 76 3 39 35 33 6 10 8 10 32

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000580665
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1630,503,919 - 30,504,001 (+)Ensembl
RefSeq Acc Id: NR_039743
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381630,503,919 - 30,504,001 (+)NCBI
GRCh371630,515,240 - 30,515,322 (+)ENTREZGENE
HuRef1628,077,923 - 28,078,005 (+)ENTREZGENE
CHM1_11631,832,426 - 31,832,508 (+)NCBI
T2T-CHM13v2.01630,890,905 - 30,890,987 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4518 COSMIC
Ensembl Genes ENSG00000266305 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580665 ENTREZGENE
GTEx ENSG00000266305 GTEx
HGNC ID HGNC:41809 ENTREZGENE
Human Proteome Map MIR4518 Human Proteome Map
miRBase MI0016884 ENTREZGENE
NCBI Gene 100616405 ENTREZGENE
RNAcentral URS00004DEA91 RNACentral
  URS0000759B50 RNACentral