MIR4497 (microRNA 4497) - Rat Genome Database
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Pathways
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Gene: MIR4497 (microRNA 4497) Homo sapiens
Analyze
Symbol: MIR4497
Name: microRNA 4497
RGD ID: 5133895
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-4497
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12109,833,348 - 109,833,436 (+)EnsemblGRCh38hg38GRCh38
GRCh3812109,833,348 - 109,833,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712110,271,153 - 110,271,241 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12q24.11NCBI
HuRef12107,287,088 - 107,287,176 (+)NCBIHuRef
CHM1_112110,238,961 - 110,239,049 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21037258   PMID:29843929   PMID:32918875  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:15931
Count of gene targets:8405
Count of transcripts:15065
Interacting mature miRNAs:hsa-miR-4497
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2
Low 47 39 36 15 22 16 112 50 40 25 53 44 2 17 42 1
Below cutoff 7 1 2 1 4 1 7 20 8 11 9 14

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000583208
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12109,833,348 - 109,833,436 (+)Ensembl
RefSeq Acc Id: NR_039718
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812109,833,348 - 109,833,436 (+)NCBI
GRCh3712110,271,153 - 110,271,241 (+)ENTREZGENE
HuRef12107,287,088 - 107,287,176 (+)ENTREZGENE
CHM1_112110,238,961 - 110,239,049 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q23.3-24.13(chr12:105234677-112194686)x1 copy number loss See cases [RCV000050807] Chr12:105234677..112194686 [GRCh38]
Chr12:105628455..112632490 [GRCh37]
Chr12:104152585..111116873 [NCBI36]
Chr12:12q23.3-24.13		 pathogenic
NR_039718.1(MIR4497):n.66C>T single nucleotide variant Brachyolmia [RCV000361825]|Charcot-Marie-Tooth disease, type 2 [RCV000304829]|Distal spinal muscular atrophy, congenital nonprogressive [RCV000339935]|Metatrophic dysplasia [RCV000393632]|Scapuloperoneal spinal muscular atrophy [RCV000310870]|Spondylometaphyseal dysplasia [RCV000403690] Chr12:109833413 [GRCh38]
Chr12:110271218 [GRCh37]
Chr12:12q24.11		 likely benign
NM_021625.4(TRPV4):c.-74G>A single nucleotide variant Brachyrachia (short spine dysplasia) [RCV000302788]|Charcot-Marie-Tooth disease axonal type 2C [RCV000354261]|Distal spinal muscular atrophy, congenital nonprogressive [RCV000336720]|Metatrophic dysplasia [RCV000403464]|Scapuloperoneal spinal muscular atrophy [RCV000405672]|Spondylometaphyseal dysplasia, Kozlowski type [RCV000296930] Chr12:109833392 [GRCh38]
Chr12:110271197 [GRCh37]
Chr12:12q24.11		 uncertain significance
NM_021625.4(TRPV4):c.-51G>A single nucleotide variant not specified [RCV000612068] Chr12:109833369 [GRCh38]
Chr12:110271174 [GRCh37]
Chr12:12q24.11		 likely benign
NM_021625.5(TRPV4):c.-59C>T single nucleotide variant Brachyrachia (short spine dysplasia) [RCV001113103]|Charcot-Marie-Tooth disease axonal type 2C [RCV001113101]|Distal spinal muscular atrophy, congenital nonprogressive [RCV001113099]|Metatrophic dysplasia [RCV001113100]|Scapuloperoneal spinal muscular atrophy [RCV001113104]|Spondylometaphyseal dysplasia, Kozlowski type [RCV001113102] Chr12:109833377 [GRCh38]
Chr12:110271182 [GRCh37]
Chr12:12q24.11		 uncertain significance
NC_000012.12:g.109833410C>A single nucleotide variant Brachyrachia (short spine dysplasia) [RCV001110452]|Charcot-Marie-Tooth disease axonal type 2C [RCV001110451]|Distal spinal muscular atrophy, congenital nonprogressive [RCV001114485]|Metatrophic dysplasia [RCV001110453]|Scapuloperoneal spinal muscular atrophy [RCV001114486]|Spondylometaphyseal dysplasia, Kozlowski type [RCV001114487] Chr12:109833410 [GRCh38]
Chr12:110271215 [GRCh37]
Chr12:12q24.11		 uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR4497 COSMIC
Ensembl Genes ENSG00000263510 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000583208 ENTREZGENE
GTEx ENSG00000263510 GTEx
HGNC ID HGNC:41737 ENTREZGENE
Human Proteome Map MIR4497 Human Proteome Map
miRBase MI0016859 ENTREZGENE
NCBI Gene 100616454 ENTREZGENE
RNAcentral URS00000A2C49 RNACentral
  URS000075D15E RNACentral