MIR4488 (microRNA 4488) - Rat Genome Database

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Gene: MIR4488 (microRNA 4488) Homo sapiens
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Symbol: MIR4488
Name: microRNA 4488
RGD ID: 5133885
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-4488
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1161,508,596 - 61,508,657 (+)EnsemblGRCh38hg38GRCh38
GRCh381161,508,596 - 61,508,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371161,276,068 - 61,276,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11q12.2NCBI
CHM1_11161,159,070 - 61,159,131 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21037258   PMID:34368354  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:72979
Count of gene targets:23179
Count of transcripts:61979
Interacting mature miRNAs:hsa-miR-4488
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium 1
Low 51 25 21 5 4 7 59 13 35 6 29 41 11 34
Below cutoff 13 5 9 5 6 5 15 16 20 1 6 9 2 9

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000577388
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1161,508,596 - 61,508,657 (+)Ensembl
RefSeq Acc Id: NR_039708
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,508,596 - 61,508,657 (+)NCBI
GRCh371161,276,068 - 61,276,129 (+)ENTREZGENE
CHM1_11161,159,070 - 61,159,131 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q12.2(chr11:61409529-61821159)x3 copy number gain See cases [RCV000136058] Chr11:61409529..61821159 [GRCh38]
Chr11:61177001..61588631 [GRCh37]
Chr11:60933577..61345207 [NCBI36]
Chr11:11q12.2
likely benign
GRCh38/hg38 11q12.2(chr11:61181337-61516830)x3 copy number gain See cases [RCV000139309] Chr11:61181337..61516830 [GRCh38]
Chr11:60948809..61284302 [GRCh37]
Chr11:60705385..61040878 [NCBI36]
Chr11:11q12.2
uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR4488 COSMIC
Ensembl Genes ENSG00000266006 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000577388 ENTREZGENE
GTEx ENSG00000266006 GTEx
HGNC ID HGNC:41599 ENTREZGENE
Human Proteome Map MIR4488 Human Proteome Map
miRBase MI0016849 ENTREZGENE
NCBI Gene 100616470 ENTREZGENE
RNAcentral URS0000419B5A RNACentral
  URS000075B350 RNACentral