MIR4524A (microRNA 4524a) - Rat Genome Database

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Gene: MIR4524A (microRNA 4524a) Homo sapiens
Analyze
Symbol: MIR4524A
Name: microRNA 4524a
RGD ID: 5133866
HGNC Page HGNC:41771
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-4524a; mir-4524a; MIR4524
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381769,099,564 - 69,099,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1769,099,564 - 69,099,632 (-)EnsemblGRCh38hg38GRCh38
GRCh371767,095,705 - 67,095,773 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q24.2NCBI
HuRef1762,481,144 - 62,481,212 (-)NCBIHuRef
CHM1_11767,160,232 - 67,160,300 (-)NCBICHM1_1
T2T-CHM13v2.01769,976,137 - 69,976,205 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21037258   PMID:21199797   PMID:21807764   PMID:21911355  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh38/hg38 17q24.2-24.3(chr17:68420514-71351235)x1 copy number loss See cases [RCV000143113] Chr17:68420514..71351235 [GRCh38]
Chr17:66416655..69347376 [GRCh37]
Chr17:63928250..66858971 [NCBI36]
Chr17:17q24.2-24.3		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q24.2-24.3(chr17:67833866-70085854)x1 copy number loss See cases [RCV000053452] Chr17:67833866..70085854 [GRCh38]
Chr17:65829982..68081995 [GRCh37]
Chr17:63260444..65593590 [NCBI36]
Chr17:17q24.2-24.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:45209
Count of gene targets:15659
Count of transcripts:34117
Interacting mature miRNAs:hsa-miR-4524a-3p, hsa-miR-4524a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000637750
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,099,564 - 69,099,632 (-)Ensembl
RefSeq Acc Id: NR_039750
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,099,564 - 69,099,632 (-)NCBI
GRCh371767,095,705 - 67,095,773 (-)ENTREZGENE
HuRef1762,481,144 - 62,481,212 (-)ENTREZGENE
CHM1_11767,160,232 - 67,160,300 (-)NCBI
T2T-CHM13v2.01769,976,137 - 69,976,205 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4524A COSMIC
Ensembl Genes ENSG00000283385 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000637750 ENTREZGENE
GTEx ENSG00000283385 GTEx
HGNC ID HGNC:41771 ENTREZGENE
Human Proteome Map MIR4524A Human Proteome Map
miRBase MI0016891 ENTREZGENE
NCBI Gene 100616316 ENTREZGENE
RNAcentral URS0000475586 RNACentral
  URS000075C58E RNACentral
  URS000075EBFC RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-11-22 MIR4524A  microRNA 4524a  MIR4524  microRNA 4524  Symbol and/or name change 5135510 APPROVED