SAP25 (Sin3A associated protein 25) - Rat Genome Database

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Gene: SAP25 (Sin3A associated protein 25) Homo sapiens
Analyze
Symbol: SAP25
Name: Sin3A associated protein 25
RGD ID: 5132311
HGNC Page HGNC:41908
Description: Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 25 kDa Sin3-associated polypeptide; histone deacetylase complex subunit SAP25; Sin3 corepressor complex subunit SAP25; sin3-associated polypeptide, 25kDa; Sin3A associated protein 25kDa; Sin3A-associated protein, 25kDa; sin3A-binding protein 25
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,572,228 - 100,573,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,572,228 - 100,573,900 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,169,851 - 100,171,523 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera794,899,650 - 94,901,069 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,801,523 - 94,802,942 (-)NCBIHuRef
CHM1_17100,100,425 - 100,101,844 (-)NCBICHM1_1
T2T-CHM13v2.07101,812,311 - 101,813,983 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,529,486 - 99,530,905 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12107411   PMID:14702039   PMID:15489334   PMID:16449650  


Genomics

Comparative Map Data
SAP25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,572,228 - 100,573,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,572,228 - 100,573,900 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,169,851 - 100,171,523 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera794,899,650 - 94,901,069 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,801,523 - 94,802,942 (-)NCBIHuRef
CHM1_17100,100,425 - 100,101,844 (-)NCBICHM1_1
T2T-CHM13v2.07101,812,311 - 101,813,983 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,529,486 - 99,530,905 (-)NCBI
Sap25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,639,735 - 137,641,164 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,639,596 - 137,641,164 (+)EnsemblGRCm39 Ensembl
GRCm385137,641,473 - 137,642,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,641,334 - 137,642,902 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,082,701 - 138,084,130 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,082,701 - 138,084,127 (+)NCBIMGSCv36mm8
Celera5134,624,779 - 134,626,207 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.59NCBI
Sap25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,692,548 - 24,693,683 (-)NCBIGRCr8
mRatBN7.21219,055,762 - 19,057,425 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,055,763 - 19,076,089 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01222,125,568 - 22,126,671 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,125,571 - 22,127,021 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,142,944 - 24,144,637 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,705,736 - 19,707,247 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1220,861,157 - 20,862,260 (-)NCBICelera
Cytogenetic Map12q12NCBI
Sap25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573328,212 - 329,890 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955573328,212 - 329,897 (+)NCBIChiLan1.0ChiLan1.0
SAP25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,478,268 - 118,485,353 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,748,306 - 166,749,985 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,599,340 - 92,601,029 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,001,455 - 106,002,892 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,001,455 - 106,002,918 (-)Ensemblpanpan1.1panPan2
SAP25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,113,955 - 9,115,567 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,114,032 - 9,116,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,818,598 - 10,820,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.069,048,368 - 9,049,943 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,048,411 - 9,050,473 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,900,891 - 8,902,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,878,562 - 8,880,137 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,060,781 - 9,062,356 (+)NCBIUU_Cfam_GSD_1.0
Sap25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,404,444 - 133,406,342 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543630,300 - 631,698 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543629,437 - 632,226 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAP25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,497,453 - 8,499,154 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,497,449 - 8,500,546 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,840,547 - 7,842,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SAP25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,639,501 - 12,641,113 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660703,663,647 - 3,665,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sap25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,504,070 - 16,505,445 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,503,994 - 16,505,554 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SAP25
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:100419914-102482826)x1 copy number loss See cases [RCV000054155] Chr7:100419914..102482826 [GRCh38]
Chr7:100017537..102123273 [GRCh37]
Chr7:99855473..101910278 [NCBI36]
Chr7:7q22.1		 pathogenic
NM_001348680.2(SAP25):c.460G>A (p.Val154Met) single nucleotide variant Inborn genetic diseases [RCV003185218] Chr7:100572911 [GRCh38]
Chr7:100170534 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1		 pathogenic|uncertain significance
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99932610-102473188)x3 copy number gain See cases [RCV000138109] Chr7:99932610..102473188 [GRCh38]
Chr7:99530233..102113635 [GRCh37]
Chr7:99368169..101900640 [NCBI36]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_001348680.2(SAP25):c.776C>G (p.Ser259Cys) single nucleotide variant Inborn genetic diseases [RCV003283764] Chr7:100572405 [GRCh38]
Chr7:100170028 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.566G>A (p.Arg189Gln) single nucleotide variant Inborn genetic diseases [RCV003265600] Chr7:100572697 [GRCh38]
Chr7:100170320 [GRCh37]
Chr7:7q22.1		 likely benign
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:100141861-100552714)x1 copy number loss not provided [RCV000746918] Chr7:100141861..100552714 [GRCh37]
Chr7:7q22.1		 likely benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_001348680.2(SAP25):c.565C>T (p.Arg189Trp) single nucleotide variant Inborn genetic diseases [RCV003248741] Chr7:100572698 [GRCh38]
Chr7:100170321 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.491A>G (p.Gln164Arg) single nucleotide variant Inborn genetic diseases [RCV003256028] Chr7:100572880 [GRCh38]
Chr7:100170503 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.549G>C (p.Ser183=) single nucleotide variant not provided [RCV000907504] Chr7:100572714 [GRCh38]
Chr7:100170337 [GRCh37]
Chr7:7q22.1		 benign
GRCh37/hg19 7q22.1(chr7:99593346-102470275)x1 copy number loss See cases [RCV001195072] Chr7:99593346..102470275 [GRCh37]
Chr7:7q22.1		 likely pathogenic
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Isolated Pierre-Robin syndrome [RCV001352649] Chr7:87477185..100333327 [GRCh37]
Chr7:7q21.12-22.1		 pathogenic
NM_001348680.2(SAP25):c.566G>C (p.Arg189Pro) single nucleotide variant Inborn genetic diseases [RCV003260384] Chr7:100572697 [GRCh38]
Chr7:100170320 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q22.1-31.1(chr7:99417471-111586308) copy number loss not specified [RCV002053711] Chr7:99417471..111586308 [GRCh37]
Chr7:7q22.1-31.1		 pathogenic
NC_000007.13:g.(?_98983338)_(100860555_?)del deletion not provided [RCV001877526] Chr7:98983338..100860555 [GRCh37]
Chr7:7q22.1		 pathogenic|uncertain significance
NC_000007.13:g.(?_98507659)_(100860555_?)dup duplication not provided [RCV003113282] Chr7:98507659..100860555 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_001348680.2(SAP25):c.322A>G (p.Lys108Glu) single nucleotide variant Inborn genetic diseases [RCV002969907] Chr7:100573141 [GRCh38]
Chr7:100170764 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.671G>A (p.Arg224His) single nucleotide variant Inborn genetic diseases [RCV002873418] Chr7:100572510 [GRCh38]
Chr7:100170133 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.612G>A (p.Met204Ile) single nucleotide variant Inborn genetic diseases [RCV002802921] Chr7:100572569 [GRCh38]
Chr7:100170192 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.398C>T (p.Thr133Met) single nucleotide variant Inborn genetic diseases [RCV002983239] Chr7:100572973 [GRCh38]
Chr7:100170596 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.395G>A (p.Arg132Gln) single nucleotide variant Inborn genetic diseases [RCV002744284] Chr7:100572976 [GRCh38]
Chr7:100170599 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.608A>C (p.Gln203Pro) single nucleotide variant Inborn genetic diseases [RCV002832602] Chr7:100572655 [GRCh38]
Chr7:100170278 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.383C>T (p.Ser128Leu) single nucleotide variant Inborn genetic diseases [RCV002670282] Chr7:100572988 [GRCh38]
Chr7:100170611 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.575G>A (p.Arg192His) single nucleotide variant Inborn genetic diseases [RCV002655184] Chr7:100572688 [GRCh38]
Chr7:100170311 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_001348680.2(SAP25):c.346C>T (p.Arg116Trp) single nucleotide variant Inborn genetic diseases [RCV003197346] Chr7:100573117 [GRCh38]
Chr7:100170740 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh38/hg38 7q22.1(chr7:98454022-100723798)x1 copy number loss Multiple congenital anomalies/dysmorphic syndrome [RCV003327701] Chr7:98454022..100723798 [GRCh38]
Chr7:7q22.1		 pathogenic
NM_001348680.2(SAP25):c.574C>T (p.Arg192Cys) single nucleotide variant Inborn genetic diseases [RCV003351900] Chr7:100572689 [GRCh38]
Chr7:100170312 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q22.1(chr7:99114000-101878272)x1 copy number loss not provided [RCV003482971] Chr7:99114000..101878272 [GRCh37]
Chr7:7q22.1		 pathogenic
GRCh37/hg19 7q22.1(chr7:98396469-102108193)x1 copy number loss not specified [RCV003986701] Chr7:98396469..102108193 [GRCh37]
Chr7:7q22.1		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:205
Interacting mature miRNAs:212
Transcripts:ENST00000538735
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1381 1485 1107 194 1165 73 2278 640 2018 89 1056 1223 121 953 1330
Low 879 1473 324 200 159 162 1833 1503 1554 27 94 102 44 251 1455 1
Below cutoff 80 6 29 15 167 16 179 42 59 49 77 120 5 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000538735   ⟹   ENSP00000442339
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7100,572,228 - 100,573,647 (-)Ensembl
RefSeq Acc Id: ENST00000611464
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7100,572,317 - 100,573,066 (-)Ensembl
RefSeq Acc Id: ENST00000614631   ⟹   ENSP00000481351
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7100,572,256 - 100,573,608 (-)Ensembl
RefSeq Acc Id: ENST00000622764   ⟹   ENSP00000481773
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7100,572,228 - 100,573,900 (-)Ensembl
RefSeq Acc Id: NM_001168682   ⟹   NP_001162153
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,572,228 - 100,573,900 (-)NCBI
GRCh377100,169,851 - 100,171,487 (-)NCBI
Celera794,899,650 - 94,901,069 (-)RGD
HuRef794,801,523 - 94,802,942 (-)ENTREZGENE
CHM1_17100,100,425 - 100,101,844 (-)NCBI
T2T-CHM13v2.07101,812,311 - 101,813,983 (-)NCBI
CRA_TCAGchr7v2799,529,486 - 99,530,905 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001348677   ⟹   NP_001335606
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,572,228 - 100,573,900 (-)NCBI
T2T-CHM13v2.07101,812,311 - 101,813,983 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001348680   ⟹   NP_001335609
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,572,228 - 100,573,900 (-)NCBI
T2T-CHM13v2.07101,812,311 - 101,813,983 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001162153 (Get FASTA)   NCBI Sequence Viewer  
  NP_001335606 (Get FASTA)   NCBI Sequence Viewer  
  NP_001335609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000442339.1
  ENSP00000481351
  ENSP00000481351.1
  ENSP00000481773
  ENSP00000481773.2
GenBank Protein Q8TEE9 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001162153   ⟸   NM_001168682
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: NP_001335609   ⟸   NM_001348680
- Peptide Label: isoform 1
- UniProtKB: A0A087WYF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001335606   ⟸   NM_001348677
- Peptide Label: isoform 3
- UniProtKB: Q8TEE9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000481773   ⟸   ENST00000622764
RefSeq Acc Id: ENSP00000481351   ⟸   ENST00000614631
RefSeq Acc Id: ENSP00000442339   ⟸   ENST00000538735

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8TEE9-F1-model_v2 AlphaFold Q8TEE9 1-199 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:41908 AgrOrtholog
COSMIC SAP25 COSMIC
Ensembl Genes ENSG00000205307 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000538735.5 UniProtKB/Swiss-Prot
  ENST00000614631 ENTREZGENE
  ENST00000614631.4 UniProtKB/Swiss-Prot
  ENST00000622764 ENTREZGENE
  ENST00000622764.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.710 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000205307 GTEx
HGNC ID HGNC:41908 ENTREZGENE
Human Proteome Map SAP25 Human Proteome Map
InterPro SAP25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:100316904 UniProtKB/Swiss-Prot
NCBI Gene 100316904 ENTREZGENE
OMIM 619230 OMIM
PANTHER HISTONE DEACETYLASE COMPLEX SUBUNIT SAP25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR39231 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SAP25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA166049074 PharmGKB
UniProt A0A087WYF9 ENTREZGENE, UniProtKB/TrEMBL
  Q8TEE9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-07 SAP25  Sin3A associated protein 25    Sin3A associated protein 25kDa  Symbol and/or name change 5135510 APPROVED
2015-11-17 SAP25  Sin3A associated protein 25kDa    Sin3A-associated protein, 25kDa  Symbol and/or name change 5135510 APPROVED