LIMS4 (LIM zinc finger domain containing 4)

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Gene: LIMS4 (LIM zinc finger domain containing 4) Homo sapiens

Analyze

No known orthologs.

Symbol:

LIMS4

Name:

LIM zinc finger domain containing 4

RGD ID:

5131296

HGNC Page

HGNC

Description:

Predicted to have metal ion binding activity. Predicted to localize to cytoplasm; focal adhesion; and plasma membrane; INTERACTS WITH doxorubicin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

FLJ59124; LIM and senescent cell antigen-like domains 3-like; LIM and senescent cell antigen-like-containing domain protein 3; LIM and senescent cell antigen-like-containing domain protein 3-like; LIM and senescent cell antigen-like-containing domain protein 4; LIM-type zinc finger domains 4; LIMS3L; MGC120847; particularly interesting new Cys-His protein 3

RGD Orthologs

Alliance Genes

More Info

homologs ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	110,446,640 - 110,473,075 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	110,386,341 - 110,473,075 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	111,194,191 - 111,230,652 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	2	q13	NCBI
HuRef	2	104,228,381 - 104,234,515 (-)	NCBI		HuRef
CHM1_1	2	111,207,620 - 111,234,810 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

doxorubicin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IEA)

focal adhesion (IEA)

plasma membrane (IEA)

Molecular Function

metal ion binding (IEA)

protein binding (IPI)

References

References - curated


1.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:15815621	PMID:25416956	PMID:32296183

Genomics

Position Markers

RH99316

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	109,278,835 - 109,278,967	UniSTS	GRCh37
Build 36	2	108,645,267 - 108,645,399	RGD	NCBI36
Cytogenetic Map	2	q12.3	UniSTS
Cytogenetic Map	2	q13	UniSTS
HuRef	2	102,878,847 - 102,878,979	UniSTS
GeneMap99-GB4 RH Map	2	387.9	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

High

Medium

Low

1010

331

413

358

157

370

Below cutoff

2572

2447

1444

265

653

123

4426

2510

1802

117

1102

1426

142

1560

3050

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001205288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001371340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_038099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017003103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017003104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017003105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA609556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC108938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC112229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC244199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF288404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK096170	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK298340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK300833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK312178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK316210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC054477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC093812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC112233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC171890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000413601 ⟹ ENSP00000404432

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	2	110,465,052 - 110,473,075 (-)	Ensembl

RefSeq Acc Id:

ENST00000480598

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	2	110,467,914 - 110,472,934 (-)	Ensembl

RefSeq Acc Id:

ENST00000632758 ⟹ ENSP00000487960

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	2	110,446,640 - 110,472,860 (-)	Ensembl

RefSeq Acc Id:

ENST00000632897 ⟹ ENSP00000488340

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	2	110,446,739 - 110,473,041 (-)	Ensembl

RefSeq Acc Id:

ENST00000633364

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	2	110,465,051 - 110,472,816 (-)	Ensembl

RefSeq Acc Id:

NM_001205288 ⟹ NP_001192217

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	110,465,051 - 110,473,075 (-)	NCBI
GRCh37	2	111,194,191 - 111,230,652 (-)	NCBI
CHM1_1	2	111,226,786 - 111,234,810 (-)	NCBI

Sequence:

show sequence

GTTTATAGCATAGTCCACTGGGACTGCCGCTCTGACAAAGACTGTGTCACTACTTTGTGGAATG
TTATTTTAGAACTTCCAGAATGCCTCAGTAAATCCTGACTGCCATGTAACTGTGTACTGTGCTG
CTGAGCTCTTAACATGAAGCAGCAGCAGTGACCCTGGCGGGCCAGGCTGACGTGCGTGGGAACA
GTGGGAGTGACCCTGGCTGGGAAGCAGGGAGGCCTGGATATTGTTTCTCCTGGCTCTGTGTCCT
GCCATTCTCATCCCTGTGCTCAGAGCTCTCAAGCACCCACGATGGCCTTCTCAGGCCGAGCGCG
CCCCTGCATTATCCCAGAGAACGAAGAAATCCCCCGAGCAGCCCTTAACACTGTCCACGAGGCC
AATGGGACCGAGGACGAGAGGGCTGTTTCCAAACTGCAGCGCAGGCACAGTGACGTGAAAGTCT
ACAAGGAGTTCTGTGACTTTTATGCGAAATTCAACATGGCCAACGCCCTGGCCAGCGCCACTTG
CGAGCGCTGCAAGGGCGGCTTTGCGCCCGCTGAGACGATCGTGAACAGTAATGGGGAGCTGTAC
CATGAGCAGTGTTTCGTGTGCGCTCAGTGCTTCCAGCAGTTCCCAGAAGGACTCTTCTATGAGG
AACGAACGTGATGGTTAAGCTACCTTCATTAAGCAGCATGACCGCTTCCTGAGCTCCTGCTGCC
GCATTTAGGCCCTGTCAGCTGTGAGGCCACTGGTGCTGAGTCAGAGGGAAAAGCTCAGAACAGC
CTTGAGCAGCGAAGAATAAAGCATGACTCATCTCGTCCTGCCCACCCCTCACACTGGACTATAA
ATACCCTCCCTGGGTCTGTGTGCTGTTATTCCAAAAGATGCGATGAATACCCAGAACTAGGCTA
TTCATGGGCTGTTGCCCAGTTCAAGCTCTATTGGGTCCTGAGGAAGATTACTATTTTGGCTACA
TTGTTTATCATTAAAACCAGCCCAGGGATGTGTAAACCTGCATCTGGAGAATAAGACATTTCTT
TTTGGTTAAATGATATTAGAGAAAAAAAAAACTATCCAAGGCTGCTAACAAATAATCTTCACTT
TCAATTATATCCAGCAATAAGTTGTTCTCCAGAAAAGAAAGCTTGGAAACTTACCCAGTTTGCC
TTCCATTTGGGACATGACTGATGTGCTTCAGTCTTTGTATAATAAATGCATCTTCGCCACTCTA
AAAAA

hide sequence

RefSeq Acc Id:

NM_001371340 ⟹ NP_001358269

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	110,445,883 - 110,472,816 (-)	NCBI

RefSeq Acc Id:

NR_038099

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	110,445,883 - 110,473,075 (-)	NCBI
GRCh37	2	111,194,191 - 111,230,652 (-)	NCBI
HuRef	2	104,228,381 - 104,234,515 (-)	NCBI
CHM1_1	2	111,207,620 - 111,234,810 (-)	NCBI

Sequence:

show sequence

GTTTATAGCATAGTCCACTGGGACTGCCGCTCTGACAAAGACTGTGTCACTACTTTGTGGAATG
TTATTTTAGAACTTCCAGAATGCCTCAGTAAATCCTGACTGCCATGTAACTGTGTACTGTGCTG
CTGAGCTCTTAACATGAAGCAGCAGCAGTGACCCTGGCGGGCCAGGCTGACGTGCGTGGGAACA
GTGGGAGTGACCCTGGCTGGGAAGCAGGGAGGCCTGGATATTGTTTCTCCTGGCTCTGTGTCCT
GCCATTCTCATCCCTGTGCTCAGAGCTCTCAAGCACCCACGATGGCCTTCTCAGGCCGAGCGCG
CCCCTGCATTATCCCAGAGAACGAAGAAATCCCCCGAGCAGCCCTTAACACTGTCCACGAGGCC
AATGGGACCGAGGACGAGAGGGCTGTTTCCAAACTGCAGCGCAGGCACAGTGACGTGAAAGTCT
ACAAGGAGTTCTGTGACTTTTATGCGAAATTCAACATGGCCAACGCCCTGGCCAGCGCCACTTG
CGAGCGCTGCAAGGGCGGCTTTGCGCCCGCTGAGACGATCGTGAACAGTAATGGGGAGCTGTAC
CATGAGCAGTGTTTCGTGTGCGCTCAGTGCTTCCAGCAGTTCCCAGAAGGACTCTTCTATGAGT
TTGAAGGAAGAAAGTACTGTGAACATGACTTTCAGATGCTCTTTGCCCCTTGCTGTCATCAGTG
TGGTGAATTCATCATTGGCCGAGTTATCAAAGCCATGAATAACAGCTGGCATCCGGAGTGCTTC
CGCTGTGACCTCTGCCAGGAAGTTCTGGCAGATATCGGGTTTGTCAAGAATGCTGGGAGACACC
TGTGTCGCCCCTGTCATAATCGTGAGAAAGCCAGAGGCCTTGGGAAATACATCTGCCAGAAATG
CCATGCTATCATCGATGAGCAGCCTCTGATATTCAAGAACGACCCCTACCATCCAGACCATTTC
AACTGCGCCAACTGCGGACAGGAAGGATCTGACTGCCGATGCACAGGAGCTGAAAGGGGAGCTA
TACTGCCTGCCATGCCATGATAAAATGGGGGTCCCCATCTGTGGCGCTTGCCGACGGCCCATCG
AAGGGCGTGTGGTGAACGCCATGGGCAAGCAGTGGCATGTGGAGCATTTTGTTTGTGCCAAGTG
TGAGAAACCCTTTCTTGGACATCGCCATTATGAGAGGAAAGGCCTGGCGTATTGTGAAACTCAC
TATAACCAGCTATTTGGTGATGTTTGCTTCCACTGCAATCGTGTTATAGAAGGTGATGTGGTCT
CTGCTCTTAATAAGGCCTGGTGCGTGAACTGCTTTGCCTGTTCTACCTGCAACACTAAATTAAC
ACTCAAGTAAGTGTACGGTTTTGTCCAGTGTGAATCCTAAGACTGAAAACTTTGGGGGGACACT
GAAAAAAAATCCTAGAATTTAGAAAAAGAGAATTATTTGATTTCTTATTTCCTCTTTCTGTTCA
GGCCTTCTGAAAGTAAAGGTTCTTCCTTTAACTGTTCCCTGTTCTTTCTTCTATTCCTTCTTTG
TCCTACTCAAAGGGATAAGTTTGTTGAAATTGACCTAAAGCCAGTCTGCAAACACTGTTATGAG
AAAATGCCAGAAGAATTTAAGAGGCGACTTGCCAAACGGGAGAGAGAAGCAAAGGATAAGGACA
AGCAGAAAAAGAAAAAGCCAGTCTGTTTGTAAACTTTTCTATCCCTGTGTCATCATTTTCACTA
CTTTCTCCTTTGGTTAGTCCTTTGGAATATGTTTTTGTTCTGTTTCTGTCTTTTGCTTTCTTCC
CCCCCTGCAACTTTTGGGCGTGTATTTGTAGTCATCAGAAATTTGGGCCAAGGGGAGCGGATCA
CGAGGTCAGGAGATCGAGACTATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACA
AAAAAAACATTAGCCAGGCGTGGTGGCGGTCGCCTGTAGTCCCAGCTCCTCAGGAGGCTGAGGC
AGGAGAATGGCTTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGACCGCGCCGCTGCACTCC
AGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAGTGTAAGTGGATTAAA
AGAGAAACTTGGTCTAGTTCATAATATTTTTAATAGGGCTTTCCCTGGCTGCTGGAAAACTTAG
GCCAGTAAGCATCTCTTTGTTTAAAGTCCTACAAGACAATTTGAAATAATTCATTGTTCATGCC
AAAATTCTAAGTACTGTTTTTCTTAGCAAGTGTAACATAATCAGGAACAATGGGTACGAGTAAA
ACATTCTTTGGATGATATTCAGAGCCTTATTAGCACTGCATCTGAATAATAGGTCATTTTGCCT
CACTCATTTGCCAAAGTAGCCATTTCTAAGTTAAGGAAGTTTTTAGATAGGCTCATAGCCTTGT
ATTTCGTTTTAGATTGTAAGCTCAATGGTAGGGATACTATATTGGTAATTATGTTTTCATATAG
CAACCACCACAGTATATTCTTGGTGCTTAATAAATGTTTATAATTGTTAACAATAA

hide sequence

RefSeq Acc Id:

XM_017003103 ⟹ XP_016858592

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	110,389,735 - 110,472,781 (-)	NCBI

Sequence:

show sequence

ACGATGGCCTTCTCAGGCCGAGCGCGCCCCTGCATTATCCCAGAGAACGAAGAAATCCCCCGAG
CAGCCCTTAACACTGTCCACGAGGCCAATGGGACCGAGGACGAGAGGGCTGTTTCCAAACTGCA
GCGCAGGCACAGTGACGTGAAAGTCTACAAGGAGTTCTGTGACTTTTATGCGAAATTCAACATG
GCCAACGCCCTGGCCAGCGCCACTTGCGAGCGCTGCAAGGGCGGCTTTGCGCCCGCTGAGACGA
TCGTGAACAGTAATGGGGAGCTGTACCATGAGCAGTGTTTCGTGTGCGCTCAGTGCTTCCAGCA
GTTCCCAGAAGGACTCTTCTATGAGTTTGAAGGAAGAAAGTACTGTGAACATGACTTTCAGATG
CTCTTTGCCCCTTGCTGTCATCAGTGTGGTGAATTCATCATTGGCCGAGTTATCAAAGCCATGA
ATAACAGCTGGCATCCGGAGTGCTTCCGCTGTGACCTCTGCCAGGAAGTTCTGGCAGATATCGG
GTTTGTCAAGAATGCTGGGAGACACCTGTGTCGCCCCTGTCATAATCGTGAGAAAGCCAGAGGC
CTTGGGAAATACATCTGCCAGAAATGCCATGCTATCATCGATGAGCAGCCTCTGATATTCAAGA
ACGACCCCTACCATCCAGACCATTTCAACTGCGCCAACTGCGGGAAGGATCTGACTGCCGATGC
ACAGGAGCTGAAAGGGGAGCTATACTGCCTGCCATGCCATGATAAAATGGGGGTCCCCATCTGT
GGCGCTTGCCGACGGCCCATCGAAGGGCGTGTGGTGAACGCCATGGGCAAGCAGTGGCATGTGG
AGCATTTTGTTTGTGCCAAGTGTGAGAAACCCTTTCTTGGACATCGCCATTATGAGAGGAAAGG
CCTGGCGTATTGTGAAACTCACTATAACCAGCTATTTGGTGATGTTTGCTTCCACTGCAATCGT
GTTATAGAAGGTGATGTGGTCTCTGCTCTTAATAAGGCCTGGTGCGTGAACTGCTTTGCCTGTT
CTACCTGCAACACTAAATTAACACTCAAATGGTGCGCTCCTGGAGGGCAGGGACCATACCATAT
CTGTCTTTTTCACTGCAGCACCCAAGCTGAACTCAGGCCCTGGAACAAGGATCTGCTTCTCCTC
CCATCCTACCCTTAGTCACCCCCTGTGATG

hide sequence

RefSeq Acc Id:

XM_017003104 ⟹ XP_016858593

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	110,388,848 - 110,472,781 (-)	NCBI

Sequence:

show sequence

ACGATGGCCTTCTCAGGCCGAGCGCGCCCCTGCATTATCCCAGAGAACGAAGAAATCCCCCGAG
CAGCCCTTAACACTGTCCACGAGGCCAATGGGACCGAGGACGAGAGGGCTGTTTCCAAACTGCA
GCGCAGGCACAGTGACGTGAAAGTCTACAAGGAGTTCTGTGACTTTTATGCGAAATTCAACATG
GCCAACGCCCTGGCCAGCGCCACTTGCGAGCGCTGCAAGGGCGGCTTTGCGCCCGCTGAGACGA
TCGTGAACAGTAATGGGGAGCTGTACCATGAGCAGTGTTTCGTGTGCGCTCAGTGCTTCCAGCA
GTTCCCAGAAGGACTCTTCTATGAGTTTGAAGGAAGAAAGTACTGTGAACATGACTTTCAGATG
CTCTTTGCCCCTTGCTGTCATCAGTGTGGTGAATTCATCATTGGCCGAGTTATCAAAGCCATGA
ATAACAGCTGGCATCCGGAGTGCTTCCGCTGTGACCTCTGCCAGGAAGTTCTGGCAGATATCGG
GTTTGTCAAGAATGCTGGGAGACACCTGTGTCGCCCCTGTCATAATCGTGAGAAAGCCAGAGGC
CTTGGGAAATACATCTGCCAGAAATGCCATGCTATCATCGATGAGCAGCCTCTGATATTCAAGA
ACGACCCCTACCATCCAGACCATTTCAACTGCGCCAACTGCGGGAAGGATCTGACTGCCGATGC
ACAGGAGCTGAAAGGGGAGCTATACTGCCTGCCATGCCATGATAAAATGGGGGTCCCCATCTGT
GGCGCTTGCCGACGGCCCATCGAAGGGCGTGTGGTGAACGCCATGGGCAAGCAGTGGCATGTGG
AGCATTTTGTTTGTGCCAAGTGTGAGAAACCCTTTCTTGGACATCGCCATTATGAGAGGAAAGG
CCTGGCGTATTGTGAAACTCACTATAACCAGCTATTTGGTGATGTTTGCTTCCACTGCAATCGT
GTTATAGAAGGTGATGTGGTCTCTGCTCTTAATAAGGCCTGGTGCGTGAACTGCTTTGCCTGTT
CTACCTGCAACACTAAATTAACACTCAAATGGTGCGCTCCTGGAGGGCAGGGACCATACCATAT
CTGTCTTTTTCACTGCAGCACCCAAGCTGAACTCAGGCCCTGGAACAAGAACTCTGGAGGTGGC
TGTCCATGCTGACCCGGGCTGTCCCCA

hide sequence

RefSeq Acc Id:

XM_017003105 ⟹ XP_016858594

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	110,386,341 - 110,472,781 (-)	NCBI

Sequence:

show sequence

ACGATGGCCTTCTCAGGCCGAGCGCGCCCCTGCATTATCCCAGAGAACGAAGAAATCCCCCGAG
CAGCCCTTAACACTGTCCACGAGGCCAATGGGACCGAGGACGAGAGGGCTGTTTCCAAACTGCA
GCGCAGGCACAGTGACGTGAAAGTCTACAAGGAGTTCTGTGACTTTTATGCGAAATTCAACATG
GCCAACGCCCTGGCCAGCGCCACTTGCGAGCGCTGCAAGGGCGGCTTTGCGCCCGCTGAGACGA
TCGTGAACAGTAATGGGGAGCTGTACCATGAGCAGTGTTTCGTGTGCGCTCAGTGCTTCCAGCA
GTTCCCAGAAGGACTCTTCTATGAGTTTGAAGGAAGAAAGTACTGTGAACATGACTTTCAGATG
CTCTTTGCCCCTTGCTGTCATCAGTGTGGTGAATTCATCATTGGCCGAGTTATCAAAGCCATGA
ATAACAGCTGGCATCCGGAGTGCTTCCGCTGTGACCTCTGCCAGGAAGTTCTGGCAGATATCGG
GTTTGTCAAGAATGCTGGGAGACACCTGTGTCGCCCCTGTCATAATCGTGAGAAAGCCAGAGGC
CTTGGGAAATACATCTGCCAGAAATGCCATGCTATCATCGATGAGCAGCCTCTGATATTCAAGA
ACGACCCCTACCATCCAGACCATTTCAACTGCGCCAACTGCGGGAAGGATCTGACTGCCGATGC
ACAGGAGCTGAAAGGGGAGCTATACTGCCTGCCATGCCATGATAAAATGGGGGTCCCCATCTGT
GGCGCTTGCCGACGGCCCATCGAAGGGCGTGTGGTGAACGCCATGGGCAAGCAGTGGCATGTGG
AGCATTTTGTTTGTGCCAAGTGTGAGAAACCCTTTCTTGGACATCGCCATTATGAGAGGAAAGG
CCTGGCGTATTGTGAAACTCACTATAACCAGCTATTTGGTGATGTTTGCTTCCACTGCAATCGT
GTTATAGAAGGTGATGTGGTCTCTGCTCTTAATAAGGCCTGGTGCGTGAACTGCTTTGCCTGTT
CTACCTGCAACACTAAATTAACACTCAAACCTTCTGCCAGAAAGTGGGCCTGCTGTGCACGCTT
CAGGGTAAGCTGCAGCCCCAGGACTGGACATTGTTGGACGAACTGCTGCAGGGCCTGCAAACAC
TGCTGCTCATGATTTTGTGGCAGGCTTCCCGTGGCCTCTTCCTGCACTACCATGTGGAGGCCCT
AACCCTGCGTCGCATCAGTAGCTTCCGCCAGTACAAGTATGACCTGGTGGCAGCGGGCAAGGCT
TTGGAGGGCATGTTCTGCAAGCTCAACCACCTCCTGGAACACCCGCACCAGCTGTTCTTCCTCT
ACCTGCTCCCCACTCTGTCCCGCTTCGTCTCCATCGGCCTCTACATGCCCGCCACCAGCTTCTT
GCTCCTGGTCCTTGGTTTCAAGGCTCTGCAACTGTGGATGCAGCTGCATGAGGCCGGAGTGGGC
CTTGAGGAGCTCAGGGGGGTCCCTGACCCTAGTGTCCCCGCTCCCCCAGCACAGGATGGTAAGC
ACACAGGTCCCAGACAGGGGCTGGATGGCTCTGAAGCTGGTAGCCCTGATCTACCTAATACTGC
AGCTGGGCTGCATCGCCCTCACCAACTTCTGACTGGACTTCCTGCTGGCCGCCACTATGGTGCT
GCCGCTGTGCTCGCCGAGCCTTTGGGCCCTGGACCCTCTGTGCTGCCCTGCTGGTGTTGACAAG
CCCAGCAGCCACGCTCCTTGGCAGCCCATTCCTGTGGCGGGAGCTGCAGGAGGCACCACTGTCA
CTGGCCAAGGGCTGGCAGCTCTTCCTGGCAGCACTGGCCCAGGGTGCGCTGGAGCACCACACCT
AAGGCGCCCTGCTCTTCCCACTGCTGTCCCTGGGCCTCTGCCCTTGCTGACTACTTTTCTGGAA
TGTGCTCTTCTGGAAGTGAGATCTGCCTGTCCGGGGCACCAGGCTGGGACAGAGACTCCCCAAG
GACCCCATTCTGCCTCCTTCTGGGGAAATAAACAAGTGCCTGTTTCAGCTGCTTTAAAAAAAAA
TAGAAAAAAAAAATGCCCTGGAAAATACTGTGTTAGCAAAAAGATTTAAAGATTGGTATAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001192217	(Get FASTA)	NCBI Sequence Viewer
	NP_001358269	(Get FASTA)	NCBI Sequence Viewer
	XP_016858592	(Get FASTA)	NCBI Sequence Viewer
	XP_016858593	(Get FASTA)	NCBI Sequence Viewer
	XP_016858594	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF99328	(Get FASTA)	NCBI Sequence Viewer
	AAH93812	(Get FASTA)	NCBI Sequence Viewer
	AAI12234	(Get FASTA)	NCBI Sequence Viewer
	AAY24131	(Get FASTA)	NCBI Sequence Viewer
	BAG35111	(Get FASTA)	NCBI Sequence Viewer
	BAG60588	(Get FASTA)	NCBI Sequence Viewer
	BAG62484	(Get FASTA)	NCBI Sequence Viewer
	BAH14581	(Get FASTA)	NCBI Sequence Viewer
	P0CW20	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001192217 ⟸ NM_001205288
- Peptide Label:	isoform 1
- UniProtKB:	P0CW20 (UniProtKB/Swiss-Prot), P0CW19 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFYAKFNMA NALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEERT hide sequence

RefSeq Acc Id:

XP_016858594 ⟸ XM_017003105

- Peptide Label:

isoform X4

- Sequence:

show sequence

MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFYAKFNMA
NALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQML
FAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGL
GKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKDLTADAQELKGELYCLPCHDKMGVPICG
ACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRV
IEGDVVSALNKAWCVNCFACSTCNTKLTLKPSARKWACCARFRVSCSPRTGHCWTNCCRACKHC
CS

hide sequence

RefSeq Acc Id:

XP_016858593 ⟸ XM_017003104

- Peptide Label:

isoform X3

- Sequence:

show sequence

MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFYAKFNMA
NALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQML
FAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGL
GKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKDLTADAQELKGELYCLPCHDKMGVPICG
ACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRV
IEGDVVSALNKAWCVNCFACSTCNTKLTLKWCAPGGQGPYHICLFHCSTQAELRPWNKNSGGGC
PC

hide sequence

RefSeq Acc Id:

XP_016858592 ⟸ XM_017003103

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFYAKFNMA
NALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQML
FAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGL
GKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKDLTADAQELKGELYCLPCHDKMGVPICG
ACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRV
IEGDVVSALNKAWCVNCFACSTCNTKLTLKWCAPGGQGPYHICLFHCSTQAELRPWNKDLLLLP
SYP

hide sequence

RefSeq Acc Id:	NP_001358269 ⟸ NM_001371340
- Peptide Label:	isoform 2

RefSeq Acc Id:

ENSP00000404432 ⟸ ENST00000413601

RefSeq Acc Id:

ENSP00000488340 ⟸ ENST00000632897

RefSeq Acc Id:

ENSP00000487960 ⟸ ENST00000632758

Protein Domains

LIM zinc-binding

Promoters

RGD ID:

6861320

Promoter ID:

EPDNEW_H3825

Type:

initiation region

Name:

LIMS4_1

Description:

LIM zinc finger domain containing 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H3826

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	110,472,816 - 110,472,876	EPDNEW

RGD ID:

6861322

Promoter ID:

EPDNEW_H3826

Type:

initiation region

Name:

LIMS4_2

Description:

LIM zinc finger domain containing 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H3825

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	110,472,985 - 110,473,045	EPDNEW

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 2q13(chr2:110104900-110611314)x3	copy number gain	Autism [RCV000050514]\|See cases [RCV000050514]	Chr2:110104900..110611314 [GRCh38] Chr2:110862477..111368891 [GRCh37] Chr2:2q13	benign
GRCh38/hg38 2q13(chr2:109936618-110452159)x1	copy number loss	See cases [RCV000053606]	Chr2:109936618..110452159 [GRCh38] Chr2:110694195..111209736 [GRCh37] Chr2:110051484..110644273 [NCBI36] Chr2:2q13	benign
GRCh38/hg38 2q13(chr2:110084138-110611314)x1	copy number loss	See cases [RCV000053608]	Chr2:110084138..110611314 [GRCh38] Chr2:110841715..111368891 [GRCh37] Chr2:110199004..111085360 [NCBI36] Chr2:2q13	benign
GRCh38/hg38 2q13(chr2:110104900-110611314)x3	copy number gain	See cases [RCV000050514]	Chr2:110104900..110611314 [GRCh38] Chr2:110862477..111368891 [GRCh37] Chr2:110219766..111085360 [NCBI36] Chr2:2q13	benign
GRCh38/hg38 2q13(chr2:110104900-110611314)x1	copy number loss	See cases [RCV000135500]	Chr2:110104900..110611314 [GRCh38] Chr2:110862477..111368891 [GRCh37] Chr2:110219766..111085360 [NCBI36] Chr2:2q13	benign
GRCh38/hg38 2q13(chr2:110025681-110576905)x1	copy number loss	See cases [RCV000136417]	Chr2:110025681..110576905 [GRCh38] Chr2:110783258..111334482 [GRCh37] Chr2:110140547..110811832 [NCBI36] Chr2:2q13	benign
GRCh38/hg38 2q13(chr2:108719125-110611314)x3	copy number gain	See cases [RCV000137361]	Chr2:108719125..110611314 [GRCh38] Chr2:109335581..111368891 [GRCh37] Chr2:108702013..111085360 [NCBI36] Chr2:2q13	uncertain significance
GRCh38/hg38 2q13(chr2:109975055-110576905)x3	copy number gain	See cases [RCV000137971]	Chr2:109975055..110576905 [GRCh38] Chr2:110732632..111334482 [GRCh37] Chr2:110089921..110775582 [NCBI36] Chr2:2q13	likely benign
GRCh38/hg38 2q11.2-13(chr2:101710825-110791418)x3	copy number gain	See cases [RCV000138645]	Chr2:101710825..110791418 [GRCh38] Chr2:102327287..111548995 [GRCh37] Chr2:101693719..111265466 [NCBI36] Chr2:2q11.2-13	pathogenic
GRCh38/hg38 2q13(chr2:110049995-110576905)x3	copy number gain	See cases [RCV000138366]	Chr2:110049995..110576905 [GRCh38] Chr2:110807572..111334482 [GRCh37] Chr2:110164861..110775582 [NCBI36] Chr2:2q13	likely benign
GRCh38/hg38 2q12.2-13(chr2:106516472-110576905)x3	copy number gain	See cases [RCV000139569]	Chr2:106516472..110576905 [GRCh38] Chr2:107132928..111334482 [GRCh37] Chr2:106499360..110857227 [NCBI36] Chr2:2q12.2-13	uncertain significance
GRCh38/hg38 2q12.2-14.1(chr2:106428663-112379067)x3	copy number gain	See cases [RCV000140834]	Chr2:106428663..112379067 [GRCh38] Chr2:107045119..113136644 [GRCh37] Chr2:106411551..112853115 [NCBI36] Chr2:2q12.2-14.1	uncertain significance
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3	copy number gain	See cases [RCV000141075]	Chr2:94678532..110602409 [GRCh38] Chr2:95344257..111359986 [GRCh37] Chr2:94707984..111076455 [NCBI36] Chr2:2q11.1-13	pathogenic
GRCh37/hg19 2q12.2-14.1(chr2:106423310-115054828)x1	copy number loss	See cases [RCV000240053]	Chr2:106423310..115054828 [GRCh37] Chr2:2q12.2-14.1	pathogenic
GRCh37/hg19 2q12.3-14.3(chr2:109798247-125658380)x1	copy number loss	See cases [RCV000240485]	Chr2:109798247..125658380 [GRCh37] Chr2:2q12.3-14.3	pathogenic
GRCh37/hg19 2q12.3-14.1(chr2:109556627-117570152)x1	copy number loss	See cases [RCV000240490]	Chr2:109556627..117570152 [GRCh37] Chr2:2q12.3-14.1	pathogenic
GRCh37/hg19 2q13(chr2:110852875-111398472)x1	copy number loss	See cases [RCV000598664]	Chr2:110852875..111398472 [GRCh37] Chr2:2q13	uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3	copy number gain	not provided [RCV000752802]	Chr2:14238..243048760 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q13(chr2:110873834-111365996)x1	copy number loss	See cases [RCV000449334]	Chr2:110873834..111365996 [GRCh37] Chr2:2q13	uncertain significance
GRCh37/hg19 2q11.1-13(chr2:95327499-111370025)x4	copy number gain	See cases [RCV000446842]	Chr2:95327499..111370025 [GRCh37] Chr2:2q11.1-13	pathogenic
GRCh37/hg19 2q13(chr2:110497990-111400649)x3	copy number gain	See cases [RCV000447601]	Chr2:110497990..111400649 [GRCh37] Chr2:2q13	likely benign
GRCh37/hg19 2q13(chr2:110504318-111365996)x1	copy number loss	See cases [RCV000445912]	Chr2:110504318..111365996 [GRCh37] Chr2:2q13	conflicting data from submitters
GRCh37/hg19 2q13(chr2:110504318-111370025)x3	copy number gain	See cases [RCV000446018]	Chr2:110504318..111370025 [GRCh37] Chr2:2q13	uncertain significance
GRCh37/hg19 2q13(chr2:111186302-113273657)	copy number gain	Abnormality of esophagus morphology [RCV000416806]	Chr2:111186302..113273657 [GRCh37] Chr2:2q13	likely pathogenic
GRCh37/hg19 2q13(chr2:110873834-111365996)x3	copy number gain	See cases [RCV000447941]	Chr2:110873834..111365996 [GRCh37] Chr2:2q13	uncertain significance
GRCh37/hg19 2q13(chr2:110874326-111365996)x1	copy number loss	See cases [RCV000448315]	Chr2:110874326..111365996 [GRCh37] Chr2:2q13	uncertain significance
GRCh37/hg19 2q13(chr2:110504318-111365996)x3	copy number gain	See cases [RCV000448330]	Chr2:110504318..111365996 [GRCh37] Chr2:2q13	uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)	copy number gain	See cases [RCV000512056]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3	copy number gain	See cases [RCV000511212]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1	copy number loss	PARP Inhibitor response [RCV000626436]	Chr2:104172062..168223828 [GRCh37] Chr2:2q12.1-24.3	drug response
Single allele	duplication	not provided [RCV000678012]	Chr2:107096423..112235727 [GRCh37] Chr2:2q12.2-13	likely pathogenic
GRCh37/hg19 2q13(chr2:110504318-111622976)x3	copy number gain	not provided [RCV000682117]	Chr2:110504318..111622976 [GRCh37] Chr2:2q13	likely benign
GRCh37/hg19 2q13(chr2:110980294-113137529)x1	copy number loss	not provided [RCV000682144]	Chr2:110980294..113137529 [GRCh37] Chr2:2q13	pathogenic
GRCh37/hg19 2q12.2-13(chr2:107020782-111365996)x1	copy number loss	not provided [RCV000682152]	Chr2:107020782..111365996 [GRCh37] Chr2:2q12.2-13	likely pathogenic
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3	copy number gain	not provided [RCV000682168]	Chr2:96353030..114045463 [GRCh37] Chr2:2q11.1-13	pathogenic
Single allele	inversion	not provided [RCV000714264]	Chr2:40608411..146900718 [GRCh37] Chr2:2p22.1-q22.3	likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3	copy number gain	not provided [RCV000752804]	Chr2:15672..243101834 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q13(chr2:110985804-111300000)x1	copy number loss	not provided [RCV000740563]	Chr2:110985804..111300000 [GRCh37] Chr2:2q13	benign
GRCh37/hg19 2q12.2-13(chr2:107029680-113187742)x1	copy number loss	not provided [RCV001259645]	Chr2:107029680..113187742 [GRCh37] Chr2:2q12.2-13	pathogenic

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	LIMS4	COSMIC
Ensembl Genes	ENSG00000256671	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSG00000256977	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSP00000404432	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSP00000405165	UniProtKB/Swiss-Prot
	ENSP00000488227	UniProtKB/Swiss-Prot
	ENSP00000488340	ENTREZGENE, UniProtKB/TrEMBL
	ENSP00000488486	UniProtKB/TrEMBL
Ensembl Transcript	ENST00000413601	ENTREZGENE, UniProtKB/Swiss-Prot
	ENST00000437679	UniProtKB/Swiss-Prot
	ENST00000480744	UniProtKB/TrEMBL
	ENST00000631420	UniProtKB/Swiss-Prot
	ENST00000632897	ENTREZGENE, UniProtKB/TrEMBL
GTEx	ENSG00000256671	GTEx
	ENSG00000256977	GTEx
HGNC ID	HGNC:39941	ENTREZGENE
Human Proteome Map	LIMS4	Human Proteome Map
InterPro	PINCH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_LIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:100288695	UniProtKB/Swiss-Prot
	hsa:96626	UniProtKB/Swiss-Prot
NCBI Gene	100288695	ENTREZGENE
PANTHER	PTHR24210	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA166049042	PharmGKB
PIRSF	PINCH	UniProtKB/TrEMBL
PROSITE	LIM_DOMAIN_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LIM_DOMAIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	LIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Hs.535619	ENTREZGENE
	Hs.735995	ENTREZGENE
UniProt	A0A0J9YXC7_HUMAN	UniProtKB/TrEMBL
	LIMS3_HUMAN	UniProtKB/Swiss-Prot
	LIMS4_HUMAN	UniProtKB/Swiss-Prot
	P0CW19	ENTREZGENE
	P0CW20	ENTREZGENE
UniProt Secondary	A0A0A6YYD2	UniProtKB/Swiss-Prot
	B4DPH6	UniProtKB/Swiss-Prot
	C9K0W2	UniProtKB/Swiss-Prot
	Q9HB10	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-16	LIMS4	LIM zinc finger domain containing 4		LIM-type zinc finger domains 4	Symbol and/or name change	5135510	APPROVED
2016-01-12	LIMS4	LIM-type zinc finger domains 4	LIMS3L	LIM and senescent cell antigen-like domains 3-like	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)