MIR3685 (microRNA 3685) - Rat Genome Database

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Gene: MIR3685 (microRNA 3685) Homo sapiens
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Symbol: MIR3685
Name: microRNA 3685
RGD ID: 4888861
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1295,309,923 - 95,309,984 (+)EnsemblGRCh38hg38GRCh38
GRCh381295,309,923 - 95,309,984 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371295,703,699 - 95,703,760 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12q22NCBI
HuRef1292,771,989 - 92,772,050 (+)NCBIHuRef
CHM1_11295,669,150 - 95,669,211 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
mancozeb  (EXP)
methylparaben  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:20459673  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:13412
Count of gene targets:7015
Count of transcripts:11960
Interacting mature miRNAs:hsa-miR-3685
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 102 13 152 103 591 107 156 46 107 151 205 251 7 3
Low 135 48 199 126 143 124 211 50 119 152 129 172 3 32 56 1
Below cutoff 15 11 12 4 3 4 25 16 20 1 7 4 7 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_037456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC084879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000579373
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1295,309,923 - 95,309,984 (+)Ensembl
RefSeq Acc Id: NR_037456
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381295,309,923 - 95,309,984 (+)NCBI
GRCh371295,703,699 - 95,703,760 (+)ENTREZGENE
HuRef1292,771,989 - 92,772,050 (+)ENTREZGENE
CHM1_11295,669,150 - 95,669,211 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3685 COSMIC
Ensembl Genes ENSG00000265917 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000579373 ENTREZGENE
GTEx ENSG00000265917 GTEx
HGNC ID HGNC:38886 ENTREZGENE
Human Proteome Map MIR3685 Human Proteome Map
miRBase MI0016086 ENTREZGENE
NCBI Gene 100500802 ENTREZGENE
RNAcentral URS0000759D24 RNACentral
  URS000075A777 RNACentral