MIR3616 (microRNA 3616) - Rat Genome Database

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Gene: MIR3616 (microRNA 3616) Homo sapiens
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Symbol: MIR3616
Name: microRNA 3616
RGD ID: 4888853
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3616
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2047,166,967 - 47,167,058 (+)EnsemblGRCh38hg38GRCh38
GRCh382047,166,967 - 47,167,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372045,795,609 - 45,795,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map20q13.12NCBI
HuRef2042,538,895 - 42,538,986 (+)NCBIHuRef
CHM1_12045,698,467 - 45,698,558 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20459774   PMID:21037258   PMID:28798470  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:61096
Count of gene targets:20253
Count of transcripts:48403
Interacting mature miRNAs:hsa-miR-3616-3p, hsa-miR-3616-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 10
Low 41 22 94 23 43 9 119 13 116 31 194 152 14 27 90
Below cutoff 59 22 59 27 8 7 113 36 80 6 52 49 21 48 80

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000584070
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2047,166,967 - 47,167,058 (+)Ensembl
RefSeq Acc Id: NR_037410
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382047,166,967 - 47,167,058 (+)NCBI
GRCh372045,795,609 - 45,795,700 (+)ENTREZGENE
HuRef2042,538,895 - 42,538,986 (+)ENTREZGENE
CHM1_12045,698,467 - 45,698,558 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q11.22-13.12(chr20:35237946-47631818)x1 copy number loss See cases [RCV000140816] Chr20:35237946..47631818 [GRCh38]
Chr20:33825749..46260562 [GRCh37]
Chr20:33289165..45693969 [NCBI36]
Chr20:20q11.22-13.12
pathogenic
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3616 COSMIC
Ensembl Genes ENSG00000264901 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000584070 ENTREZGENE
GTEx ENSG00000264901 GTEx
HGNC ID HGNC:38943 ENTREZGENE
Human Proteome Map MIR3616 Human Proteome Map
miRBase MI0016006 ENTREZGENE
NCBI Gene 100500814 ENTREZGENE
RNAcentral URS000075D1FC RNACentral
  URS000075D53C RNACentral
  URS000075EF21 RNACentral