MIR3677 (microRNA 3677) - Rat Genome Database
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Gene: MIR3677 (microRNA 3677) Homo sapiens
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Symbol: MIR3677
Name: microRNA 3677
RGD ID: 4888852
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3677
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl162,270,713 - 2,270,772 (+)EnsemblGRCh38hg38GRCh38
GRCh38162,270,713 - 2,270,772 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37162,320,714 - 2,320,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map16p13.3NCBI
HuRef162,246,761 - 2,246,820 (+)NCBIHuRef
CHM1_1162,320,671 - 2,320,730 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20459673   PMID:21037258   PMID:21199797   PMID:30621516  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:50660
Count of gene targets:18114
Count of transcripts:41695
Interacting mature miRNAs:hsa-miR-3677-3p, hsa-miR-3677-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 9 1 13 1 89 3 4 8 23 5 38 39
Low 214 56 212 125 362 117 226 78 218 223 254 375 16 15 44 3
Below cutoff 16 15 12 4 7 1 16 8 48 4 5 9 3 6 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000578964
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl162,270,713 - 2,270,772 (+)Ensembl
RefSeq Acc Id: NR_037448
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38162,270,713 - 2,270,772 (+)NCBI
GRCh37162,320,714 - 2,320,773 (+)ENTREZGENE
HuRef162,246,761 - 2,246,820 (+)ENTREZGENE
CHM1_1162,320,671 - 2,320,730 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.3-13.13(chr16:46766-11525516)x3 copy number gain See cases [RCV000133780] Chr16:46766..11525516 [GRCh38]
Chr16:96766..11619372 [GRCh37]
Chr16:36766..11526873 [NCBI36]
Chr16:16p13.3-13.13
pathogenic
GRCh38/hg38 16p13.3(chr16:46766-4247185)x3 copy number gain See cases [RCV000136687] Chr16:46766..4247185 [GRCh38]
Chr16:96766..4297186 [GRCh37]
Chr16:36766..4237187 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3-13.12(chr16:43732-13326806)x3 copy number gain See cases [RCV000139166] Chr16:43732..13326806 [GRCh38]
Chr16:93732..13420663 [GRCh37]
Chr16:33732..13328164 [NCBI36]
Chr16:16p13.3-13.12
pathogenic
GRCh38/hg38 16p13.3-13.11(chr16:666662-15743104)x3 copy number gain See cases [RCV000143710] Chr16:666662..15743104 [GRCh38]
Chr16:716662..15836961 [GRCh37]
Chr16:656663..15744462 [NCBI36]
Chr16:16p13.3-13.11
pathogenic
GRCh38/hg38 16p13.3-13.13(chr16:23141-11296695)x3 copy number gain See cases [RCV000052367] Chr16:23141..11296695 [GRCh38]
Chr16:73141..11390552 [GRCh37]
Chr16:13141..11298053 [NCBI36]
Chr16:16p13.3-13.13
pathogenic
GRCh38/hg38 16p13.3(chr16:29941-2560460)x3 copy number gain See cases [RCV000052368] Chr16:29941..2560460 [GRCh38]
Chr16:79941..2610461 [GRCh37]
Chr16:19941..2550462 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:46766-3214623)x3 copy number gain See cases [RCV000052370] Chr16:46766..3214623 [GRCh38]
Chr16:96766..3264623 [GRCh37]
Chr16:36766..3204624 [NCBI36]
Chr16:16p13.3
pathogenic
NC_000016.9:g.2127606_2334390dup duplication Endometrial carcinoma [RCV000588521] Chr16:2077605..2284389 [GRCh38]
Chr16:2127606..2334390 [GRCh37]
Chr16:16p13.3
uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR3677 COSMIC
Ensembl Genes ENSG00000266643 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578964 ENTREZGENE
GTEx ENSG00000266643 GTEx
HGNC ID HGNC:38932 ENTREZGENE
Human Proteome Map MIR3677 Human Proteome Map
miRBase MI0016078 ENTREZGENE
NCBI Gene 100500812 ENTREZGENE
RNAcentral URS0000171020 RNACentral
  URS0000307592 RNACentral
  URS000075A213 RNACentral