MIR3605 (microRNA 3605) - Rat Genome Database
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Gene: MIR3605 (microRNA 3605) Homo sapiens
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Symbol: MIR3605
Name: microRNA 3605
RGD ID: 4888815
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3605
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl133,332,393 - 33,332,492 (-)EnsemblGRCh38hg38GRCh38
GRCh38133,332,393 - 33,332,492 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37133,797,994 - 33,798,093 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p35.1NCBI
HuRef131,914,231 - 31,914,330 (-)NCBIHuRef
CHM1_1133,913,369 - 33,913,468 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
paracetamol  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:20224791   PMID:20459774   PMID:21037258   PMID:26646931  


Genomics

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
RPLP1hsa-miR-3605-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:34099
Count of gene targets:12265
Count of transcripts:25026
Interacting mature miRNAs:hsa-miR-3605-3p, hsa-miR-3605-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 43 35 4 3 5 1 1 1 4
Low 970 1795 828 169 884 86 2152 678 1034 56 480 905 83 719 1498
Below cutoff 420 428 221 94 132 66 554 495 542 28 116 96 28 173 357

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000583214
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl133,332,393 - 33,332,492 (-)Ensembl
RefSeq Acc Id: NR_037400
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38133,332,393 - 33,332,492 (-)NCBI
GRCh37133,797,994 - 33,798,093 (-)ENTREZGENE
HuRef131,914,231 - 31,914,330 (-)ENTREZGENE
CHM1_1133,913,369 - 33,913,468 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2
pathogenic
GRCh38/hg38 1p35.2-35.1(chr1:30766758-33359428)x1 copy number loss See cases [RCV000053802] Chr1:30766758..33359428 [GRCh38]
Chr1:31239605..33825029 [GRCh37]
Chr1:31012192..33597616 [NCBI36]
Chr1:1p35.2-35.1
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3605 COSMIC
Ensembl Genes ENSG00000284154 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000583214 ENTREZGENE
GTEx ENSG00000284154 GTEx
HGNC ID HGNC:38922 ENTREZGENE
Human Proteome Map MIR3605 Human Proteome Map
miRBase MI0015995 ENTREZGENE
NCBI Gene 100500853 ENTREZGENE
RNAcentral URS00000A9FB9 RNACentral
  URS000018C677 RNACentral
  URS000075BFBA RNACentral