MIR3657 (microRNA 3657) - Rat Genome Database

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Pathways
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Gene: MIR3657 (microRNA 3657) Homo sapiens
Analyze
Symbol: MIR3657
Name: microRNA 3657
RGD ID: 4888782
HGNC Page HGNC:38906
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,037,599 - 112,037,715 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12112,037,599 - 112,037,715 (-)EnsemblGRCh38hg38GRCh38
GRCh3712112,475,403 - 112,475,519 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12q24.13NCBI
HuRef12109,488,688 - 109,488,806 (-)NCBIHuRef
CHM1_112112,443,650 - 112,443,766 (-)NCBICHM1_1
T2T-CHM13v2.012112,014,501 - 112,014,617 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
chromium(6+)  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:20483914  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q23.3-24.13(chr12:105234677-112194686)x1 copy number loss See cases [RCV000050807] Chr12:105234677..112194686 [GRCh38]
Chr12:105628455..112632490 [GRCh37]
Chr12:104152585..111116873 [NCBI36]
Chr12:12q23.3-24.13		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:22792
Count of gene targets:11193
Count of transcripts:21422
Interacting mature miRNAs:hsa-miR-3657
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 4 34 1 1 1 3 3
Low 155 55 124 91 358 94 300 66 183 117 189 277 7 35 86 3
Below cutoff 97 94 80 26 25 16 315 54 148 33 76 83 10 67 199

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000584818
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12112,037,599 - 112,037,715 (-)Ensembl
RefSeq Acc Id: NR_037430
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812112,037,599 - 112,037,715 (-)NCBI
GRCh3712112,475,403 - 112,475,519 (-)ENTREZGENE
HuRef12109,488,688 - 109,488,806 (-)ENTREZGENE
CHM1_112112,443,650 - 112,443,766 (-)NCBI
T2T-CHM13v2.012112,014,501 - 112,014,617 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR3657 COSMIC
Ensembl Genes ENSG00000266370 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000584818 ENTREZGENE
GTEx ENSG00000266370 GTEx
HGNC ID HGNC:38906 ENTREZGENE
Human Proteome Map MIR3657 Human Proteome Map
miRBase MI0016057 ENTREZGENE
NCBI Gene 100500889 ENTREZGENE
RNAcentral URS000075B6BC RNACentral
  URS000075C59B RNACentral