Ren<sup>em1Mcwi</sup> (renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Renem1Mcwi (renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Renem1Mcwi
Name: renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 4139863
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is a 10-bp frameshift deletion in exon 5 (del 578-587); this causes a truncation of the message from 1451 to 1441 bp leading to a frameshift and premature truncation of the normal open reading frame after codon 185.
ASSOCIATED WITH abnormal kidney morphology; decreased body weight; decreased circulating bicarbonate level
Type: allele  of Ren  
Previously known as: renem2mcwi; Ren^[em1Mcwi]; Renem1Mcwi; renin; zinc-finger nuclease induced mutant 2, Medical College of Wisconsin
Is Marker For: Strains:   SS-Renem1Mcwi   SS-Renem1Mcwi-/-   SS-Renem1Mcwi+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map13 RGD


References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Creation and characterization of a renin knockout rat. Moreno C, etal., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Renem1Mcwi-var1 chr13 44803412 44803421 GCCAAGTTTG - deletion mRatBN7.2

Related Rat Strains
The following Strains have been annotated to Renem1Mcwi
SS-Renem1Mcwi+/-     SS-Renem1Mcwi-/-     SS-Renem1Mcwi    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information