Sh2b3<sup>em1Mcwi</sup> (SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Sh2b3em1Mcwi (SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Sh2b3em1Mcwi
Name: SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 4139858
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an in-frame 6-bp deletion in exon 2 (del 847-852).
ASSOCIATED WITH decreased susceptibility to hypertension; decreased urine albumin level; increased regulatory T cell number; ASSOCIATED WITH Albuminuria; hypertension
Type: allele  of Sh2b3  
Also known as: Sh2b3em1Mcwi
Is Marker For: Strains:   SS-Sh2b3em1Mcwi   SS-Sh2b3em1Mcwi-/-   SS-Sh2b3em1Mcwi-/+  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map12 RGD


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References


Genomics


Related Rat Strains
The following Strains have been annotated to Sh2b3em1Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Rat Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type
Sh2b3em1Mcwi-var1 chr12 40262913 40262918 CACTTG - deletion

Additional Information