Cd36-ps1 (CD36 molecule, pseudogene 1) - Rat Genome Database

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Gene: Cd36-ps1 (CD36 molecule, pseudogene 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cd36-ps1
Name: CD36 molecule, pseudogene 1
RGD ID: 41249586
Description: Predicted to enable several functions, including amyloid-beta binding activity; fatty acid transmembrane transporter activity; and lipoprotein particle binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis. Predicted to be located in several cellular components, including apical plasma membrane; brush border membrane; and external side of plasma membrane. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule).
Type: pseudo
RefSeq Status: MODEL
Previously known as: LOC120093085; platelet glycoprotein 4-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2417,487,837 - 17,514,900 (+)NCBImRatBN7.2mRatBN7.2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (IEA)
amyloid-beta clearance by cellular catabolic process  (IEA)
apoptotic cell clearance  (IEA)
cell adhesion  (IEA)
cell surface receptor signaling pathway  (IEA)
cellular response to amyloid-beta  (IEA)
cellular response to diacyl bacterial lipopeptide  (IEA)
cellular response to hydroperoxide  (IEA)
cellular response to lipopolysaccharide  (IEA)
cellular response to lipoteichoic acid  (IEA)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA)
cGMP-mediated signaling  (IEA)
cholesterol import  (IEA)
defense response to Gram-positive bacterium  (IEA)
energy homeostasis  (IEA)
intestinal cholesterol absorption  (IEA)
lipid storage  (IEA)
lipid transport  (IEA)
lipid transport across blood-brain barrier  (IEA)
lipoprotein transport  (IEA)
long-chain fatty acid import across plasma membrane  (IEA)
low-density lipoprotein particle clearance  (IEA)
low-density lipoprotein particle mediated signaling  (IEA)
MAPK cascade  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of protein import into nucleus  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
nitric oxide mediated signal transduction  (IEA)
oxidised low-density lipoprotein particle clearance  (IEA)
phagocytosis, recognition  (IEA)
positive regulation of blood coagulation  (IEA)
positive regulation of blood microparticle formation  (IEA)
positive regulation of cell death  (IEA)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of cholesterol storage  (IEA)
positive regulation of cold-induced thermogenesis  (ISS)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of macrophage cytokine production  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of nitric oxide biosynthetic process  (IEA)
positive regulation of NLRP3 inflammasome complex assembly  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phagocytosis, engulfment  (IEA)
positive regulation of reactive oxygen species biosynthetic process  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
receptor internalization  (IEA)
regulation of action potential  (IEA)
regulation of removal of superoxide radicals  (IEA)
regulation of toll-like receptor signaling pathway  (IEA)
response to linoleic acid  (IEA)
response to stilbenoid  (IEA)
sensory perception of taste  (IEA)
short-chain fatty acid transport  (IEA)
triglyceride transport  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. Putri M, etal., Biochem Biophys Res Commun. 2015 Feb 20;457(4):520-5. doi: 10.1016/j.bbrc.2014.12.124. Epub 2015 Jan 13.

Genomics

Variants

.
Variants in Cd36-ps1
788 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XR_005503413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XR_005503413
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2417,487,837 - 17,514,900 (+)NCBI
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F5B5-F1-model_v2 AlphaFold F7F5B5 1-472 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:41249586 AgrOrtholog
BioCyc Gene G2FUF-45913 BioCyc
Ensembl Genes ENSRNOG00000005906 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008319.8 UniProtKB/TrEMBL
  ENSRNOP00000058398.4 UniProtKB/TrEMBL
  ENSRNOP00000063867.3 UniProtKB/TrEMBL
  ENSRNOP00000067980.2 UniProtKB/TrEMBL
  ENSRNOP00000068300.2 UniProtKB/TrEMBL
  ENSRNOP00000069273.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008319.9 UniProtKB/TrEMBL
  ENSRNOT00000061687 ENTREZGENE
  ENSRNOT00000061687.6 UniProtKB/TrEMBL
  ENSRNOT00000067543.4 UniProtKB/TrEMBL
  ENSRNOT00000076573.3 UniProtKB/TrEMBL
  ENSRNOT00000076946.3 UniProtKB/TrEMBL
  ENSRNOT00000091249.2 UniProtKB/TrEMBL
InterPro CD36/SCARB1/SNMP1 UniProtKB/TrEMBL
  CD36_chordates UniProtKB/TrEMBL
  CD36_fam UniProtKB/TrEMBL
KEGG Report rno:29184 UniProtKB/TrEMBL
NCBI Gene LOC120093085 ENTREZGENE
PANTHER PTHR11923 UniProtKB/TrEMBL
  PTHR11923:SF12 UniProtKB/TrEMBL
Pfam CD36 UniProtKB/TrEMBL
PhenoGen Cd36-ps1 PhenoGen
PRINTS CD36ANTIGEN UniProtKB/TrEMBL
  CD36FAMILY UniProtKB/TrEMBL
UniProt A0A096MJ39_RAT UniProtKB/TrEMBL
  A0A096MJX7_RAT UniProtKB/TrEMBL
  A0A0G2JUY0_RAT UniProtKB/TrEMBL
  A0A8J8YQ28_RAT UniProtKB/TrEMBL
  F7F5B5_RAT UniProtKB/TrEMBL
  F7F6C5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-10 Cd36-ps1  CD36 molecule, pseudogene 1  LOC120093085  platelet glycoprotein 4-like  Symbol and Name Changed 1299863 APPROVED
2021-01-27 LOC120093085  platelet glycoprotein 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL