MIR4300 (microRNA 4300) - Rat Genome Database
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Gene: MIR4300 (microRNA 4300) Homo sapiens
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Symbol: MIR4300
Name: microRNA 4300
RGD ID: 4109082
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1181,890,741 - 81,890,836 (-)EnsemblGRCh38hg38GRCh38
GRCh381181,890,741 - 81,890,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371181,601,783 - 81,601,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1178,910,624 - 78,910,719 (-)NCBI
Cytogenetic Map11q14.1NCBI
HuRef1177,897,900 - 77,897,995 (-)NCBIHuRef
CHM1_11181,484,786 - 81,484,881 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:19784364   PMID:29016859  


Genomics

Position Markers
D11S4453  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371181,602,891 - 81,603,238UniSTSGRCh37
Build 361181,280,539 - 81,280,886RGDNCBI36
Celera1178,911,732 - 78,912,082RGD
HuRef1177,899,008 - 77,899,364UniSTS
Marshfield Genetic Map1184.38UniSTS
deCODE Assembly Map1188.48UniSTS

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:36415
Count of gene targets:15339
Count of transcripts:32723
Interacting mature miRNAs:hsa-miR-4300
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage entire extraembryonic component
High
Medium
Low 1 3 2 4 3 6 2 3 3 6 2 1 1
Below cutoff 2 1 1 3 1 3 4 6 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_036186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AP002802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000581016
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1181,890,741 - 81,890,836 (-)Ensembl
RefSeq Acc Id: NR_036186
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381181,890,741 - 81,890,836 (-)NCBI
GRCh371181,601,783 - 81,601,878 (-)RGD
Celera1178,910,624 - 78,910,719 (-)RGD
HuRef1177,897,900 - 77,897,995 (-)ENTREZGENE
CHM1_11181,484,786 - 81,484,881 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.5-22.1(chr11:75941754-98357960)x1 copy number loss See cases [RCV000133838] Chr11:75941754..98357960 [GRCh38]
Chr11:75652798..98228688 [GRCh37]
Chr11:75330446..97733898 [NCBI36]
Chr11:11q13.5-22.1
pathogenic
GRCh38/hg38 11q14.1(chr11:81686030-82113389)x1 copy number loss See cases [RCV000135576] Chr11:81686030..82113389 [GRCh38]
Chr11:81397072..81824431 [GRCh37]
Chr11:81074720..81502079 [NCBI36]
Chr11:11q14.1
pathogenic|uncertain significance
GRCh38/hg38 11q14.1(chr11:80281651-82521009)x1 copy number loss See cases [RCV000139112] Chr11:80281651..82521009 [GRCh38]
Chr11:79992695..82232051 [GRCh37]
Chr11:79670343..81909699 [NCBI36]
Chr11:11q14.1
uncertain significance
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3
pathogenic
GRCh38/hg38 11q14.1-14.2(chr11:78362208-86165380)x3 copy number gain See cases [RCV000053637] Chr11:78362208..86165380 [GRCh38]
Chr11:78073254..85876422 [GRCh37]
Chr11:77750902..85554070 [NCBI36]
Chr11:11q14.1-14.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4300 COSMIC
Ensembl Genes ENSG00000264110 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000581016 ENTREZGENE
GTEx ENSG00000264110 GTEx
HGNC ID HGNC:38184 ENTREZGENE
Human Proteome Map MIR4300 Human Proteome Map
miRBase MI0015831 ENTREZGENE
NCBI Gene 100422823 ENTREZGENE
PharmGKB PA165543476 PharmGKB
RNAcentral URS000075A674 RNACentral
  URS000075C0A4 RNACentral