MIR4301 (microRNA 4301) - Rat Genome Database

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Gene: MIR4301 (microRNA 4301) Homo sapiens
Analyze
Symbol: MIR4301
Name: microRNA 4301
RGD ID: 4109052
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11113,450,023 - 113,450,088 (-)EnsemblGRCh38hg38GRCh38
GRCh3811113,450,023 - 113,450,088 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711113,320,745 - 113,320,810 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera11110,473,681 - 110,473,746 (-)NCBI
Cytogenetic Map11q23.2NCBI
HuRef11109,249,173 - 109,249,238 (-)NCBIHuRef
CHM1_111113,203,730 - 113,203,795 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:19784364   PMID:24058526   PMID:29236292   PMID:30964168  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:14802
Count of gene targets:8450
Count of transcripts:14303
Interacting mature miRNAs:hsa-miR-4301
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1
Low 10 3 3 7 1 18 5 18 3 16 13 2 5
Below cutoff 2 2 2 2 4 3 2 3 12 2 2 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000577203
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11113,450,023 - 113,450,088 (-)Ensembl
RefSeq Acc Id: NR_036183
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811113,450,023 - 113,450,088 (-)NCBI
GRCh3711113,320,745 - 113,320,810 (-)RGD
Celera11110,473,681 - 110,473,746 (-)RGD
HuRef11109,249,173 - 109,249,238 (-)ENTREZGENE
CHM1_111113,203,730 - 113,203,795 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q23.2-25(chr11:112864326-131189315)x3 copy number gain See cases [RCV000137582] Chr11:112864326..131189315 [GRCh38]
Chr11:112832130..131059210 [GRCh37]
Chr11:112240259..130564420 [NCBI36]
Chr11:11q23.2-25
pathogenic
GRCh38/hg38 11q23.2-23.3(chr11:113444446-120648921)x3 copy number gain See cases [RCV000050627] Chr11:113444446..120648921 [GRCh38]
Chr11:113315168..120519630 [GRCh37]
Chr11:112820378..120024840 [NCBI36]
Chr11:11q23.2-23.3
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4301 COSMIC
Ensembl Genes ENSG00000265140 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000577203 ENTREZGENE
GTEx ENSG00000265140 GTEx
HGNC ID HGNC:38323 ENTREZGENE
Human Proteome Map MIR4301 Human Proteome Map
miRBase MI0015828 ENTREZGENE
NCBI Gene 100422855 ENTREZGENE
PharmGKB PA165543477 PharmGKB
RNAcentral URS000075A09B RNACentral
  URS000075DDFA RNACentral