MIR4295 (microRNA 4295) - Rat Genome Database

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Gene: MIR4295 (microRNA 4295) Homo sapiens
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Symbol: MIR4295
Name: microRNA 4295
RGD ID: 4108997
HGNC Page HGNC:38220
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810112,634,170 - 112,634,254 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10112,634,170 - 112,634,254 (+)EnsemblGRCh38hg38GRCh38
GRCh3710114,393,929 - 114,394,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera10108,121,641 - 108,121,725 (+)NCBICelera
Cytogenetic Map10q25.2NCBI
HuRef10108,021,548 - 108,021,632 (+)NCBIHuRef
CHM1_110114,675,716 - 114,675,800 (+)NCBICHM1_1
T2T-CHM13v2.010113,524,974 - 113,525,058 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:19784364   PMID:25656529   PMID:26756701   PMID:27447744   PMID:29407175   PMID:29457293   PMID:31118494   PMID:32141101   PMID:34758714  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q25.1-26.3(chr10:108102587-133620674)x3 copy number gain See cases [RCV000133688] Chr10:108102587..133620674 [GRCh38]
Chr10:109862345..135434178 [GRCh37]
Chr10:109852335..135284168 [NCBI36]
Chr10:10q25.1-26.3
pathogenic
GRCh38/hg38 10q25.2-25.3(chr10:112074094-115537174)x1 copy number loss See cases [RCV000135960] Chr10:112074094..115537174 [GRCh38]
Chr10:113833852..117032437 [GRCh37]
Chr10:113823842..117286674 [NCBI36]
Chr10:10q25.2-25.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.2-25.3(chr10:110804735-114884010)x1 copy number loss See cases [RCV000139783] Chr10:110804735..114884010 [GRCh38]
Chr10:112564493..116643769 [GRCh37]
Chr10:112554483..116633759 [NCBI36]
Chr10:10q25.2-25.3
likely pathogenic
GRCh38/hg38 10q24.32-25.3(chr10:102732173-114085105)x1 copy number loss See cases [RCV000143371] Chr10:102732173..114085105 [GRCh38]
Chr10:104491930..115844864 [GRCh37]
Chr10:104481920..115834854 [NCBI36]
Chr10:10q24.32-25.3
pathogenic
GRCh38/hg38 10q25.2-26.3(chr10:111313099-133620674)x3 copy number gain See cases [RCV000051218] Chr10:111313099..133620674 [GRCh38]
Chr10:113072857..135434178 [GRCh37]
Chr10:113062847..135284168 [NCBI36]
Chr10:10q25.2-26.3
pathogenic
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q25.1-26.11(chr10:107191100-118761489)x1 copy number loss See cases [RCV000052570] Chr10:107191100..118761489 [GRCh38]
Chr10:108950858..120521001 [GRCh37]
Chr10:108940848..120510991 [NCBI36]
Chr10:10q25.1-26.11
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:106925303-133620815)x3 copy number gain See cases [RCV000053588] Chr10:106925303..133620815 [GRCh38]
Chr10:108685061..135434319 [GRCh37]
Chr10:108675051..135284309 [NCBI36]
Chr10:10q25.1-26.3
pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:9942
Count of gene targets:4577
Count of transcripts:8419
Interacting mature miRNAs:hsa-miR-4295
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 2 3 1
Low 26 10 21 15 113 16 32 19 28 18 28 25 1 2 15 2
Below cutoff 30 6 14 3 30 3 26 20 24 16 21 22 2 8 9 1

Sequence


RefSeq Acc Id: ENST00000585286
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10112,634,170 - 112,634,254 (+)Ensembl
RefSeq Acc Id: NR_036177
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,634,170 - 112,634,254 (+)NCBI
GRCh3710114,393,929 - 114,394,013 (+)RGD
Celera10108,121,641 - 108,121,725 (+)RGD
HuRef10108,021,548 - 108,021,632 (+)ENTREZGENE
CHM1_110114,675,716 - 114,675,800 (+)NCBI
T2T-CHM13v2.010113,524,974 - 113,525,058 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4295 COSMIC
Ensembl Genes ENSG00000264763 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000585286 ENTREZGENE
GTEx ENSG00000264763 GTEx
HGNC ID HGNC:38220 ENTREZGENE
Human Proteome Map MIR4295 Human Proteome Map
miRBase MI0015822 ENTREZGENE
NCBI Gene 100422909 ENTREZGENE
PharmGKB PA165548865 PharmGKB
RNAcentral URS000075BA14 RNACentral
  URS000075E4DB RNACentral