MIR3186 (microRNA 3186) - Rat Genome Database

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Gene: MIR3186 (microRNA 3186) Homo sapiens
Analyze
Symbol: MIR3186
Name: microRNA 3186
RGD ID: 4108974
HGNC Page HGNC:38311
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-3186
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,451,104 - 81,451,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,451,104 - 81,451,188 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,418,130 - 79,418,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1776,065,339 - 76,065,423 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1774,867,335 - 74,867,419 (-)NCBIHuRef
CHM1_11779,504,382 - 79,504,466 (-)NCBICHM1_1
T2T-CHM13v2.01782,368,114 - 82,368,198 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20224791   PMID:20300190   PMID:21037258   PMID:35220908  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q25.3(chr17:81008196-83102584)x3 copy number gain See cases [RCV000138688] Chr17:81008196..83102584 [GRCh38]
Chr17:78981996..81048189 [GRCh37]
Chr17:76596591..78653749 [NCBI36]
Chr17:17q25.3		 pathogenic
GRCh38/hg38 17q25.3(chr17:81401966-83084062)x1 copy number loss See cases [RCV000142007] Chr17:81401966..83084062 [GRCh38]
Chr17:79375766..81041938 [GRCh37]
Chr17:76990361..78635227 [NCBI36]
Chr17:17q25.3		 likely pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3		 pathogenic
GRCh38/hg38 17q25.3(chr17:78092236-83086677)x3 copy number gain See cases [RCV000050685] Chr17:78092236..83086677 [GRCh38]
Chr17:76088317..81044553 [GRCh37]
Chr17:73599912..78637842 [NCBI36]
Chr17:17q25.3		 pathogenic
GRCh38/hg38 17q25.3(chr17:78901959-83086677)x3 copy number gain See cases [RCV000050934] Chr17:78901959..83086677 [GRCh38]
Chr17:76898041..81044553 [GRCh37]
Chr17:74409636..78637842 [NCBI36]
Chr17:17q25.3		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3		 pathogenic
GRCh38/hg38 17q25.3(chr17:78918650-83021095)x3 copy number gain See cases [RCV000052497] Chr17:78918650..83021095 [GRCh38]
Chr17:76914732..80978971 [GRCh37]
Chr17:74426327..78572260 [NCBI36]
Chr17:17q25.3		 pathogenic
GRCh38/hg38 17q25.3(chr17:80328106-83086677)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053454]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053454]|See cases [RCV000053454] Chr17:80328106..83086677 [GRCh38]
Chr17:78301906..81044553 [GRCh37]
Chr17:75916501..78637842 [NCBI36]
Chr17:17q25.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:17460
Count of gene targets:8527
Count of transcripts:15782
Interacting mature miRNAs:hsa-miR-3186-3p, hsa-miR-3186-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 5 2 3 2 13 3 16 6 24 6 9 31
Low 295 176 456 112 127 103 504 130 603 141 315 473 14 111 257 1
Below cutoff 233 160 146 35 68 19 246 156 356 28 101 116 17 113 143

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000577404
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1781,451,104 - 81,451,188 (-)Ensembl
RefSeq Acc Id: NR_036152
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,451,104 - 81,451,188 (-)NCBI
GRCh371779,418,130 - 79,418,214 (-)RGD
Celera1776,065,339 - 76,065,423 (-)RGD
HuRef1774,867,335 - 74,867,419 (-)RGD
CHM1_11779,504,382 - 79,504,466 (-)NCBI
T2T-CHM13v2.01782,368,114 - 82,368,198 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR3186 COSMIC
Ensembl Genes ENSG00000266189 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000577404 ENTREZGENE
GTEx ENSG00000266189 GTEx
HGNC ID HGNC:38311 ENTREZGENE
Human Proteome Map MIR3186 Human Proteome Map
miRBase MI0014229 ENTREZGENE
NCBI Gene 100422944 ENTREZGENE
PharmGKB PA165432123 PharmGKB
RNAcentral URS00004CFC54 RNACentral
  URS000075C3AF RNACentral
  URS000075F01B RNACentral