MIR3189 (microRNA 3189) - Rat Genome Database
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Pathways
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Gene: MIR3189 (microRNA 3189) Homo sapiens
Analyze
Symbol: MIR3189
Name: microRNA 3189
RGD ID: 4108966
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3189
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,386,562 - 18,386,634 (+)EnsemblGRCh38hg38GRCh38
GRCh381918,386,562 - 18,386,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,497,372 - 18,497,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1918,399,201 - 18,399,273 (+)NCBI
Cytogenetic Map19p13.11NCBI
CHM1_11918,497,613 - 18,497,685 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21037258   PMID:21199797   PMID:25645911   PMID:25698447   PMID:29342841  


Genomics

Position Markers
PMC26624P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371918,496,138 - 18,496,995UniSTSGRCh37
Build 361918,357,138 - 18,357,995RGDNCBI36
Celera1918,397,967 - 18,398,824RGD
Cytogenetic Map19p13.11UniSTS

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:73912
Count of gene targets:20620
Count of transcripts:54700
Interacting mature miRNAs:hsa-miR-3189-3p, hsa-miR-3189-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 103 101 90 13 93 36 3 7 128 62 52 3
Low 103 20 140 98 146 100 189 28 65 145 163 198 3 23 20 1
Below cutoff 12 18 7 6 26 2 21 22 26 12 10 12 4 9 15

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000578735
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1918,386,562 - 18,386,634 (+)Ensembl
RefSeq Acc Id: NR_036156
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381918,386,562 - 18,386,634 (+)NCBI
GRCh371918,497,372 - 18,497,444 (+)RGD
Celera1918,399,201 - 18,399,273 (+)RGD
CHM1_11918,497,613 - 18,497,685 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19p13.12-12(chr19:15133594-24193591)x3 copy number gain See cases [RCV000136696] Chr19:15133594..24193591 [GRCh38]
Chr19:15244405..24376393 [GRCh37]
Chr19:15105405..24168233 [NCBI36]
Chr19:19p13.12-12		 pathogenic|likely pathogenic
GRCh38/hg38 19p13.11(chr19:18133970-18424117)x1 copy number loss See cases [RCV000142944] Chr19:18133970..18424117 [GRCh38]
Chr19:18244780..18534927 [GRCh37]
Chr19:18105780..18395927 [NCBI36]
Chr19:19p13.11		 uncertain significance
GRCh38/hg38 19p13.11-q13.11(chr19:17176767-34924150)x3 copy number gain See cases [RCV000050635] Chr19:17176767..34924150 [GRCh38]
Chr19:17287576..35415054 [GRCh37]
Chr19:17148576..40106894 [NCBI36]
Chr19:19p13.11-q13.11		 pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11		 pathogenic
GRCh38/hg38 19p13.11(chr19:17922234-18463153)x1 copy number loss See cases [RCV000053946] Chr19:17922234..18463153 [GRCh38]
Chr19:18033043..18573963 [GRCh37]
Chr19:17894043..18434963 [NCBI36]
Chr19:19p13.11		 pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3189 COSMIC
Ensembl Genes ENSG00000264175 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578735 ENTREZGENE
GTEx ENSG00000264175 GTEx
HGNC ID HGNC:38307 ENTREZGENE
Human Proteome Map MIR3189 Human Proteome Map
miRBase MI0014233 ENTREZGENE
NCBI Gene 100422943 ENTREZGENE
PharmGKB PA165393774 PharmGKB
RNAcentral URS00001B12A4 RNACentral
  URS000054ED3F RNACentral
  URS000075DBDF RNACentral