MIR3141 (microRNA 3141) - Rat Genome Database

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Gene: MIR3141 (microRNA 3141) Homo sapiens
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Symbol: MIR3141
Name: microRNA 3141
RGD ID: 4108962
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3141
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5154,596,012 - 154,596,072 (-)EnsemblGRCh38hg38GRCh38
GRCh385154,596,012 - 154,596,072 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375153,975,572 - 153,975,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera5150,051,128 - 150,051,188 (-)NCBI
Cytogenetic Map5q33.2NCBI
HuRef5149,116,421 - 149,116,481 (-)NCBIHuRef
CHM1_15153,408,032 - 153,408,092 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
doxorubicin  (EXP)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21037258  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:47161
Count of gene targets:17315
Count of transcripts:42020
Interacting mature miRNAs:hsa-miR-3141
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium 1
Low 6 5 3 6 7 3 3 1 9 3 1 6
Below cutoff 2 1 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000585290
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5154,596,012 - 154,596,072 (-)Ensembl
RefSeq Acc Id: NR_036094
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385154,596,012 - 154,596,072 (-)NCBI
GRCh375153,975,572 - 153,975,632 (-)RGD
Celera5150,051,128 - 150,051,188 (-)RGD
HuRef5149,116,421 - 149,116,481 (-)ENTREZGENE
CHM1_15153,408,032 - 153,408,092 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q33.1-34(chr5:152443869-166104392)x1 copy number loss See cases [RCV000138282] Chr5:152443869..166104392 [GRCh38]
Chr5:151823430..165531397 [GRCh37]
Chr5:151803623..165463975 [NCBI36]
Chr5:5q33.1-34
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3
pathogenic
GRCh38/hg38 5q33.1-34(chr5:152761187-167248053)x1 copy number loss See cases [RCV000052144] Chr5:152761187..167248053 [GRCh38]
Chr5:152140747..166675058 [GRCh37]
Chr5:152120940..166607636 [NCBI36]
Chr5:5q33.1-34
pathogenic
GRCh38/hg38 5q33.1-34(chr5:153195314-164014005)x1 copy number loss See cases [RCV000052145] Chr5:153195314..164014005 [GRCh38]
Chr5:152574874..163441011 [GRCh37]
Chr5:152555067..163373589 [NCBI36]
Chr5:5q33.1-34
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3141 COSMIC
Ensembl Genes ENSG00000264760 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000585290 ENTREZGENE
GTEx ENSG00000264760 GTEx
HGNC ID HGNC:38326 ENTREZGENE
Human Proteome Map MIR3141 Human Proteome Map
miRBase MI0014165 ENTREZGENE
NCBI Gene 100422950 ENTREZGENE
PharmGKB PA165660379 PharmGKB
RNAcentral URS00002F72ED RNACentral
  URS000075BA80 RNACentral