MIR3146 (microRNA 3146) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MIR3146 (microRNA 3146) Homo sapiens
Analyze
Symbol: MIR3146
Name: microRNA 3146
RGD ID: 4108942
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3146
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl719,705,358 - 19,705,436 (-)EnsemblGRCh38hg38GRCh38
GRCh38719,705,358 - 19,705,436 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37719,744,981 - 19,745,059 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera719,729,282 - 19,729,360 (-)NCBI
Cytogenetic Map7p21.1NCBI
HuRef719,634,135 - 19,634,213 (-)NCBIHuRef
CHM1_1719,745,782 - 19,745,860 (-)NCBICHM1_1
CRA_TCAGchr7v2719,796,386 - 19,796,464 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21037258   PMID:21199797   PMID:25256182  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:11611
Count of gene targets:6181
Count of transcripts:10159
Interacting mature miRNAs:hsa-miR-3146
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 3 27 2
Low 65 14 71 59 257 61 89 45 72 57 100 114 1 3 11 2
Below cutoff 19 5 9 1 9 1 10 9 11 13 14 18 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000580367
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl719,705,358 - 19,705,436 (-)Ensembl
RefSeq Acc Id: NR_036101
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38719,705,358 - 19,705,436 (-)NCBI
GRCh37719,744,981 - 19,745,059 (-)RGD
Celera719,729,282 - 19,729,360 (-)RGD
HuRef719,634,135 - 19,634,213 (-)RGD
CHM1_1719,745,782 - 19,745,860 (-)NCBI
CRA_TCAGchr7v2719,796,386 - 19,796,464 (-)ENTREZGENE
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p22.3-15.2(chr7:54185-26827634)x3 copy number gain See cases [RCV000136557] Chr7:54185..26827634 [GRCh38]
Chr7:54185..26867253 [GRCh37]
Chr7:149268..26833778 [NCBI36]
Chr7:7p22.3-15.2
pathogenic
GRCh38/hg38 7p21.1(chr7:19178547-20733512)x3 copy number gain See cases [RCV000136582] Chr7:19178547..20733512 [GRCh38]
Chr7:19218170..20773135 [GRCh37]
Chr7:19184695..20739660 [NCBI36]
Chr7:7p21.1
uncertain significance
GRCh38/hg38 7p21.1-15.3(chr7:19145712-22193713)x1 copy number loss See cases [RCV000136842] Chr7:19145712..22193713 [GRCh38]
Chr7:19185335..22233331 [GRCh37]
Chr7:19151860..22199856 [NCBI36]
Chr7:7p21.1-15.3
pathogenic
GRCh38/hg38 7p22.1-15.2(chr7:5682209-27230311)x3 copy number gain See cases [RCV000136649] Chr7:5682209..27230311 [GRCh38]
Chr7:5721840..27269930 [GRCh37]
Chr7:5688366..27236455 [NCBI36]
Chr7:7p22.1-15.2
pathogenic
GRCh38/hg38 7p21.2-21.1(chr7:16121516-20607899)x1 copy number loss See cases [RCV000137236] Chr7:16121516..20607899 [GRCh38]
Chr7:16161141..20647522 [GRCh37]
Chr7:16127666..20614047 [NCBI36]
Chr7:7p21.2-21.1
pathogenic
GRCh38/hg38 7p22.3-15.3(chr7:45130-25221165)x3 copy number gain See cases [RCV000137824] Chr7:45130..25221165 [GRCh38]
Chr7:45130..25260784 [GRCh37]
Chr7:140213..25227309 [NCBI36]
Chr7:7p22.3-15.3
pathogenic
GRCh38/hg38 7p21.2-15.3(chr7:15533812-24851432)x1 copy number loss See cases [RCV000137924] Chr7:15533812..24851432 [GRCh38]
Chr7:15573437..24891051 [GRCh37]
Chr7:15539962..24857576 [NCBI36]
Chr7:7p21.2-15.3
pathogenic
GRCh38/hg38 7p21.1(chr7:18660228-20666885)x3 copy number gain See cases [RCV000138724] Chr7:18660228..20666885 [GRCh38]
Chr7:18699851..20706508 [GRCh37]
Chr7:18666376..20673033 [NCBI36]
Chr7:7p21.1
uncertain significance
GRCh38/hg38 7p22.3-15.2(chr7:1698124-27207295)x3 copy number gain See cases [RCV000143060] Chr7:1698124..27207295 [GRCh38]
Chr7:1737760..27246914 [GRCh37]
Chr7:1704286..27213439 [NCBI36]
Chr7:7p22.3-15.2
pathogenic
GRCh38/hg38 7p21.3-15.2(chr7:10610069-25760560)x1 copy number loss See cases [RCV000142708] Chr7:10610069..25760560 [GRCh38]
Chr7:10649696..25800180 [GRCh37]
Chr7:10616221..25766705 [NCBI36]
Chr7:7p21.3-15.2
pathogenic
GRCh38/hg38 7p22.3-15.2(chr7:43360-27196404)x3 copy number gain See cases [RCV000143586] Chr7:43360..27196404 [GRCh38]
Chr7:43360..27236023 [GRCh37]
Chr7:138443..27202548 [NCBI36]
Chr7:7p22.3-15.2
pathogenic
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p21.3-15.3(chr7:8274775-21988311)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052280]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052280]|See cases [RCV000052280] Chr7:8274775..21988311 [GRCh38]
Chr7:8314405..22027929 [GRCh37]
Chr7:8280930..21994454 [NCBI36]
Chr7:7p21.3-15.3
pathogenic
GRCh38/hg38 7p21.1-15.3(chr7:18505390-21417733)x1 copy number loss See cases [RCV000052304] Chr7:18505390..21417733 [GRCh38]
Chr7:18545013..21457351 [GRCh37]
Chr7:18511538..21423876 [NCBI36]
Chr7:7p21.1-15.3
pathogenic
GRCh38/hg38 7p22.3-15.3(chr7:53985-24361531)x3 copy number gain See cases [RCV000053528] Chr7:53985..24361531 [GRCh38]
Chr7:53985..24401150 [GRCh37]
Chr7:149068..24367675 [NCBI36]
Chr7:7p22.3-15.3
pathogenic
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3 copy number gain See cases [RCV000053530] Chr7:54185..37089712 [GRCh38]
Chr7:54185..37129317 [GRCh37]
Chr7:149268..37095842 [NCBI36]
Chr7:7p22.3-14.2
pathogenic
GRCh38/hg38 7p21.2-15.2(chr7:16234212-26167278)x3 copy number gain See cases [RCV000053531] Chr7:16234212..26167278 [GRCh38]
Chr7:16273837..26206898 [GRCh37]
Chr7:16240362..26173423 [NCBI36]
Chr7:7p21.2-15.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3146 COSMIC
Ensembl Genes ENSG00000265932 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580367 ENTREZGENE
GTEx ENSG00000265932 GTEx
HGNC ID HGNC:38368 ENTREZGENE
Human Proteome Map MIR3146 Human Proteome Map
miRBase MI0014172 ENTREZGENE
NCBI Gene 100422967 ENTREZGENE
PharmGKB PA165618155 PharmGKB
RNAcentral URS00003AAF6D RNACentral
  URS000075BE4B RNACentral