MIR3173 (microRNA 3173) - Rat Genome Database

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Gene: MIR3173 (microRNA 3173) Homo sapiens
Analyze
Symbol: MIR3173
Name: microRNA 3173
RGD ID: 4108931
HGNC Page HGNC:38174
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and negative regulation of cell migration. Located in extracellular space.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-3173
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381495,137,919 - 95,137,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1495,137,919 - 95,137,986 (-)EnsemblGRCh38hg38GRCh38
GRCh371495,604,256 - 95,604,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1475,660,375 - 75,660,442 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,788,137 - 75,788,204 (-)NCBIHuRef
CHM1_11495,542,493 - 95,542,560 (-)NCBICHM1_1
T2T-CHM13v2.01489,368,138 - 89,368,205 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21037258   PMID:21199797   PMID:22454130   PMID:26646931   PMID:29066351  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.11-32.13(chr14:90255156-95274696)x1 copy number loss See cases [RCV000051551] Chr14:90255156..95274696 [GRCh38]
Chr14:90721500..95741033 [GRCh37]
Chr14:89791253..94810786 [NCBI36]
Chr14:14q32.11-32.13		 pathogenic
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2		 pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33		 pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:81092
Count of gene targets:22369
Count of transcripts:59167
Interacting mature miRNAs:hsa-miR-3173-3p, hsa-miR-3173-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 13 1
Low 64 10 53 32 210 32 53 36 52 41 81 90 2 1 2
Below cutoff 6 1 8 6 12 9 4 4 10 6 11 21 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000580810
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1495,137,919 - 95,137,986 (-)Ensembl
RefSeq Acc Id: NR_036131
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381495,137,919 - 95,137,986 (-)NCBI
GRCh371495,604,256 - 95,604,323 (-)RGD
Celera1475,660,375 - 75,660,442 (-)RGD
HuRef1475,788,137 - 75,788,204 (-)ENTREZGENE
CHM1_11495,542,493 - 95,542,560 (-)NCBI
T2T-CHM13v2.01489,368,138 - 89,368,205 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR3173 COSMIC
Ensembl Genes ENSG00000264607 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580810 ENTREZGENE
GTEx ENSG00000264607 GTEx
HGNC ID HGNC:38174 ENTREZGENE
Human Proteome Map MIR3173 Human Proteome Map
miRBase MI0014204 ENTREZGENE
NCBI Gene 100422981 ENTREZGENE
PharmGKB PA165479177 PharmGKB
RNAcentral URS000017CCCB RNACentral
  URS00004216E6 RNACentral
  URS000075C556 RNACentral