MIR3158-2 (microRNA 3158-2) - Rat Genome Database
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Gene: MIR3158-2 (microRNA 3158-2) Homo sapiens
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Symbol: MIR3158-2
Name: microRNA 3158-2
RGD ID: 4108868
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3158-2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10101,601,417 - 101,601,497 (-)EnsemblGRCh38hg38GRCh38
GRCh3810101,601,417 - 101,601,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710103,361,174 - 103,361,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1097,099,960 - 97,100,040 (-)NCBI
Cytogenetic Map10q24.32NCBI
CHM1_110103,644,853 - 103,644,933 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20224791   PMID:20300190   PMID:21037258   PMID:26646931  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:56627
Count of gene targets:17814
Count of transcripts:42123
Interacting mature miRNAs:hsa-miR-3158-3p, hsa-miR-3158-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000637571
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10101,601,417 - 101,601,497 (-)Ensembl
RefSeq Acc Id: NR_036115
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810101,601,417 - 101,601,497 (-)NCBI
GRCh3710103,361,174 - 103,361,254 (-)RGD
Celera1097,099,960 - 97,100,040 (-)RGD
CHM1_110103,644,853 - 103,644,933 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q24.32(chr10:101434986-101689541)x3 copy number gain See cases [RCV000136104] Chr10:101434986..101689541 [GRCh38]
Chr10:103194743..103449298 [GRCh37]
Chr10:103184733..103439288 [NCBI36]
Chr10:10q24.32
uncertain significance
GRCh38/hg38 10q24.32(chr10:101492028-101682260)x3 copy number gain See cases [RCV000137122] Chr10:101492028..101682260 [GRCh38]
Chr10:103251785..103442017 [GRCh37]
Chr10:103241775..103432007 [NCBI36]
Chr10:10q24.32
uncertain significance
GRCh38/hg38 10q24.32(chr10:101599084-101676484)x3 copy number gain See cases [RCV000136700] Chr10:101599084..101676484 [GRCh38]
Chr10:103358841..103436241 [GRCh37]
Chr10:103348831..103426231 [NCBI36]
Chr10:10q24.32
uncertain significance
GRCh38/hg38 10q24.32(chr10:101209582-101748381)x3 copy number gain See cases [RCV000137417] Chr10:101209582..101748381 [GRCh38]
Chr10:102969339..103508138 [GRCh37]
Chr10:102959329..103498128 [NCBI36]
Chr10:10q24.32
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q24.32(chr10:101510559-101748381)x3 copy number gain See cases [RCV000143048] Chr10:101510559..101748381 [GRCh38]
Chr10:103270316..103508138 [GRCh37]
Chr10:103260306..103498128 [NCBI36]
Chr10:10q24.32
uncertain significance
GRCh38/hg38 10q24.31-24.32(chr10:101177305-101719109)x3 copy number gain See cases [RCV000143261] Chr10:101177305..101719109 [GRCh38]
Chr10:102937062..103478866 [GRCh37]
Chr10:102927052..103468856 [NCBI36]
Chr10:10q24.31-24.32
pathogenic
GRCh38/hg38 10q24.32(chr10:101599084-101689575)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051651]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051651]|See cases [RCV000051651] Chr10:101599084..101689575 [GRCh38]
Chr10:103358841..103449332 [GRCh37]
Chr10:103348831..103439322 [NCBI36]
Chr10:10q24.32
uncertain significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q24.32(chr10:101416272-101689575)x1 copy number loss See cases [RCV000052566] Chr10:101416272..101689575 [GRCh38]
Chr10:103176029..103449332 [GRCh37]
Chr10:103166019..103439322 [NCBI36]
Chr10:10q24.32
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q24.31-24.32(chr10:101120347-101831908)x3 copy number gain See cases [RCV000053565] Chr10:101120347..101831908 [GRCh38]
Chr10:102880104..103591665 [GRCh37]
Chr10:102870094..103581655 [NCBI36]
Chr10:10q24.31-24.32
pathogenic
GRCh38/hg38 10q24.32(chr10:101297763-101618190)x3 copy number gain See cases [RCV000053586] Chr10:101297763..101618190 [GRCh38]
Chr10:103057520..103377947 [GRCh37]
Chr10:103047510..103367937 [NCBI36]
Chr10:10q24.32
pathogenic
GRCh38/hg38 10q24.32(chr10:101491828-101668176)x3 copy number gain See cases [RCV000053587] Chr10:101491828..101668176 [GRCh38]
Chr10:103251585..103427933 [GRCh37]
Chr10:103241575..103417923 [NCBI36]
Chr10:10q24.32
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3158-2 COSMIC
Ensembl Genes ENSG00000283558 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000637571 ENTREZGENE
GTEx ENSG00000283558 GTEx
HGNC ID HGNC:38279 ENTREZGENE
Human Proteome Map MIR3158-2 Human Proteome Map
miRBase MI0014187 ENTREZGENE
NCBI Gene 100423033 ENTREZGENE
PharmGKB PA165548833 PharmGKB
RNAcentral URS0000221D0E RNACentral
  URS000040D577 RNACentral
  URS000075F0B6 RNACentral