MIR3126 (microRNA 3126) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MIR3126 (microRNA 3126) Homo sapiens
Analyze
Symbol: MIR3126
Name: microRNA 3126
RGD ID: 4108867
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3126
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl269,103,682 - 69,103,755 (+)EnsemblGRCh38hg38GRCh38
GRCh38269,103,682 - 69,103,755 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37269,330,814 - 69,330,887 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera269,181,838 - 69,181,911 (+)NCBI
Cytogenetic Map2p13.3NCBI
HuRef269,066,639 - 69,066,712 (+)NCBIHuRef
CHM1_1269,260,088 - 69,260,161 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:19784364   PMID:20224791   PMID:20300190   PMID:21037258   PMID:21199797   PMID:28079796  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:50256
Count of gene targets:18451
Count of transcripts:41062
Interacting mature miRNAs:hsa-miR-3126-3p, hsa-miR-3126-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium 1 2 1
Low 18 7 14 3 18 3 57 29 45 23 46 43 1 6
Below cutoff 4 2 5 2 7 3 9 5 11 9 5 14 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000577443
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl269,103,682 - 69,103,755 (+)Ensembl
RefSeq Acc Id: NR_036073
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38269,103,682 - 69,103,755 (+)NCBI
GRCh37269,330,814 - 69,330,887 (+)RGD
Celera269,181,838 - 69,181,911 (+)RGD
HuRef269,066,639 - 69,066,712 (+)RGD
CHM1_1269,260,088 - 69,260,161 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_032208.2(ANTXR1):c.801C>T (p.Leu267=) single nucleotide variant Malignant melanoma [RCV000060596] Chr2:69102939 [GRCh38]
Chr2:69330071 [GRCh37]
Chr2:69183575 [NCBI36]
Chr2:2p13.3		 not provided
NM_032208.2(ANTXR1):c.802A>T (p.Asn268Tyr) single nucleotide variant Malignant melanoma [RCV000065645] Chr2:69102940 [GRCh38]
Chr2:69330072 [GRCh37]
Chr2:69183576 [NCBI36]
Chr2:2p13.3		 not provided
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2		 pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2		 uncertain significance
GRCh38/hg38 2p14-13.3(chr2:64587095-69876311)x1 copy number loss See cases [RCV000140691] Chr2:64587095..69876311 [GRCh38]
Chr2:64814229..70103443 [GRCh37]
Chr2:64667733..69956947 [NCBI36]
Chr2:2p14-13.3		 likely pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign

Additional Information

Database Acc Id Source(s)
COSMIC MIR3126 COSMIC
Ensembl Genes ENSG00000266649 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000577443 ENTREZGENE
GTEx ENSG00000266649 GTEx
HGNC ID HGNC:38225 ENTREZGENE
Human Proteome Map MIR3126 Human Proteome Map
miRBase MI0014143 ENTREZGENE
NCBI Gene 100423030 ENTREZGENE
PharmGKB PA165696807 PharmGKB
RNAcentral URS0000022AAA RNACentral
  URS0000052E4D RNACentral
  URS000075DA6A RNACentral