MIR3176 (microRNA 3176) - Rat Genome Database
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Gene: MIR3176 (microRNA 3176) Homo sapiens
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Symbol: MIR3176
Name: microRNA 3176
RGD ID: 4108864
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3176
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl16543,277 - 543,366 (+)EnsemblGRCh38hg38GRCh38
GRCh3816543,277 - 543,366 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716593,277 - 593,366 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera16793,663 - 793,752 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16514,664 - 514,753 (+)NCBIHuRef
CHM1_116593,214 - 593,303 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21037258   PMID:21199797  


Genomics

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PPANhsa-miR-3176Mirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:44379
Count of gene targets:18205
Count of transcripts:39847
Interacting mature miRNAs:hsa-miR-3176
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 118 9 48 42 279 45 160 47 97 60 121 176 6 1
Low 796 473 728 226 606 175 1059 408 1006 204 665 692 53 321 629 3
Below cutoff 413 474 243 104 232 66 617 443 565 33 153 147 38 218 411

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000582210
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl16543,277 - 543,366 (+)Ensembl
RefSeq Acc Id: NR_036137
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3816543,277 - 543,366 (+)NCBI
GRCh3716593,277 - 593,366 (+)RGD
Celera16793,663 - 793,752 (+)RGD
HuRef16514,664 - 514,753 (+)ENTREZGENE
CHM1_116593,214 - 593,303 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.3-13.13(chr16:46766-11525516)x3 copy number gain See cases [RCV000133780] Chr16:46766..11525516 [GRCh38]
Chr16:96766..11619372 [GRCh37]
Chr16:36766..11526873 [NCBI36]
Chr16:16p13.3-13.13
pathogenic
GRCh38/hg38 16p13.3(chr16:46766-1544014)x1 copy number loss See cases [RCV000134917] Chr16:46766..1544014 [GRCh38]
Chr16:96766..1594015 [GRCh37]
Chr16:36766..1534016 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:521803-558532)x1 copy number loss See cases [RCV000136220] Chr16:521803..558532 [GRCh38]
Chr16:571803..608532 [GRCh37]
Chr16:511804..548533 [NCBI36]
Chr16:16p13.3
benign
GRCh38/hg38 16p13.3(chr16:46766-4247185)x3 copy number gain See cases [RCV000136687] Chr16:46766..4247185 [GRCh38]
Chr16:96766..4297186 [GRCh37]
Chr16:36766..4237187 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:46722-1867327)x1 copy number loss See cases [RCV000137826] Chr16:46722..1867327 [GRCh38]
Chr16:96722..1917328 [GRCh37]
Chr16:36722..1857329 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:46766-882211)x1 copy number loss See cases [RCV000137979] Chr16:46766..882211 [GRCh38]
Chr16:96766..932211 [GRCh37]
Chr16:36766..872212 [NCBI36]
Chr16:16p13.3
pathogenic|uncertain significance
GRCh38/hg38 16p13.3(chr16:412341-925326)x3 copy number gain See cases [RCV000139354] Chr16:412341..925326 [GRCh38]
Chr16:462341..975326 [GRCh37]
Chr16:402342..915327 [NCBI36]
Chr16:16p13.3
uncertain significance
GRCh38/hg38 16p13.3-13.12(chr16:43732-13326806)x3 copy number gain See cases [RCV000139166] Chr16:43732..13326806 [GRCh38]
Chr16:93732..13420663 [GRCh37]
Chr16:33732..13328164 [NCBI36]
Chr16:16p13.3-13.12
pathogenic
GRCh38/hg38 16p13.3(chr16:534395-722554)x3 copy number gain See cases [RCV000140349] Chr16:534395..722554 [GRCh38]
Chr16:584395..772554 [GRCh37]
Chr16:524396..712555 [NCBI36]
Chr16:16p13.3
benign
GRCh38/hg38 16p13.3(chr16:59980-1221651)x1 copy number loss See cases [RCV000141384] Chr16:59980..1221651 [GRCh38]
Chr16:109978..1271651 [GRCh37]
Chr16:49978..1211652 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:492760-565476)x3 copy number gain See cases [RCV000141138] Chr16:492760..565476 [GRCh38]
Chr16:542760..615476 [GRCh37]
Chr16:482761..555477 [NCBI36]
Chr16:16p13.3
benign|likely benign|conflicting data from submitters
GRCh38/hg38 16p13.3(chr16:35880-605262)x1 copy number loss See cases [RCV000143709] Chr16:35880..605262 [GRCh38]
Chr16:85880..655262 [GRCh37]
Chr16:25880..595263 [NCBI36]
Chr16:16p13.3
uncertain significance
GRCh38/hg38 16p13.3-13.13(chr16:23141-11296695)x3 copy number gain See cases [RCV000052367] Chr16:23141..11296695 [GRCh38]
Chr16:73141..11390552 [GRCh37]
Chr16:13141..11298053 [NCBI36]
Chr16:16p13.3-13.13
pathogenic
GRCh38/hg38 16p13.3(chr16:29941-2560460)x3 copy number gain See cases [RCV000052368] Chr16:29941..2560460 [GRCh38]
Chr16:79941..2610461 [GRCh37]
Chr16:19941..2550462 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:46566-1800860)x3 copy number gain See cases [RCV000052369] Chr16:46566..1800860 [GRCh38]
Chr16:96566..1850861 [GRCh37]
Chr16:36566..1790862 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:46766-3214623)x3 copy number gain See cases [RCV000052370] Chr16:46766..3214623 [GRCh38]
Chr16:96766..3264623 [GRCh37]
Chr16:36766..3204624 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:239680-589745)x3 copy number gain See cases [RCV000052371] Chr16:239680..589745 [GRCh38]
Chr16:289679..639745 [GRCh37]
Chr16:229680..579746 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:23141-1773349)x1 copy number loss See cases [RCV000053251] Chr16:23141..1773349 [GRCh38]
Chr16:73141..1823350 [GRCh37]
Chr16:13141..1763351 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:23141-1712523)x1 copy number loss See cases [RCV000053252] Chr16:23141..1712523 [GRCh38]
Chr16:73141..1762524 [GRCh37]
Chr16:13141..1702525 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:46766-1997582)x1 copy number loss See cases [RCV000053253] Chr16:46766..1997582 [GRCh38]
Chr16:96766..2047583 [GRCh37]
Chr16:36766..1987584 [NCBI36]
Chr16:16p13.3
pathogenic
GRCh38/hg38 16p13.3(chr16:105429-1499893)x1 copy number loss See cases [RCV000053267] Chr16:105429..1499893 [GRCh38]
Chr16:155427..1549894 [GRCh37]
Chr16:95427..1489895 [NCBI36]
Chr16:16p13.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3176 COSMIC
Ensembl Genes ENSG00000266235 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000582210 ENTREZGENE
GTEx ENSG00000266235 GTEx
HGNC ID HGNC:38345 ENTREZGENE
Human Proteome Map MIR3176 Human Proteome Map
miRBase MI0014210 ENTREZGENE
NCBI Gene 100423037 ENTREZGENE
PharmGKB PA165450156 PharmGKB
RNAcentral URS00004AAAFF RNACentral
  URS000075C750 RNACentral