MIR4313 (microRNA 4313) - Rat Genome Database
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Gene: MIR4313 (microRNA 4313) Homo sapiens
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Symbol: MIR4313
Name: microRNA 4313
RGD ID: 4108863
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1575,762,215 - 75,762,315 (-)EnsemblGRCh38hg38GRCh38
GRCh381575,762,215 - 75,762,315 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371576,054,556 - 76,054,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1552,980,235 - 52,980,335 (-)NCBI
Cytogenetic Map15q24.2NCBI
HuRef1552,810,829 - 52,810,929 (-)NCBIHuRef
CHM1_11576,174,038 - 76,174,138 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
schizophrenia  (IAGP)

References
Additional References at PubMed
PMID:16381832   PMID:19784364  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:34564
Count of gene targets:14166
Count of transcripts:32597
Interacting mature miRNAs:hsa-miR-4313
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_036198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC019294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000580760
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1575,762,215 - 75,762,315 (-)Ensembl
RefSeq Acc Id: NR_036198
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381575,762,215 - 75,762,315 (-)NCBI
GRCh371576,054,556 - 76,054,656 (-)RGD
Celera1552,980,235 - 52,980,335 (-)RGD
HuRef1552,810,829 - 52,810,929 (-)ENTREZGENE
CHM1_11576,174,038 - 76,174,138 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q23-25.1(chr15:70025300-78705993)x1 copy number loss See cases [RCV000141666] Chr15:70025300..78705993 [GRCh38]
Chr15:70317639..78998335 [GRCh37]
Chr15:68104693..76785390 [NCBI36]
Chr15:15q23-25.1
pathogenic
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3 copy number gain See cases [RCV000143019] Chr15:72154949..101920998 [GRCh38]
Chr15:72447290..102461201 [GRCh37]
Chr15:70234344..100278724 [NCBI36]
Chr15:15q23-26.3
pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3
pathogenic
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|See cases [RCV000052346] Chr15:75307767..101723215 [GRCh38]
Chr15:75600108..102263418 [GRCh37]
Chr15:73387161..100080941 [NCBI36]
Chr15:15q24.2-26.3
pathogenic
GRCh38/hg38 15q23-24.2(chr15:70788624-76057736)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053219]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053219]|See cases [RCV000053219] Chr15:70788624..76057736 [GRCh38]
Chr15:71080963..76350077 [GRCh37]
Chr15:68868017..74137132 [NCBI36]
Chr15:15q23-24.2
pathogenic
GRCh38/hg38 15q24.2(chr15:75596961-76049787)x1 copy number loss See cases [RCV000053223] Chr15:75596961..76049787 [GRCh38]
Chr15:75889302..76342128 [GRCh37]
Chr15:73676357..74129183 [NCBI36]
Chr15:15q24.2
pathogenic
Single allele duplication Schizophrenia [RCV000754167] Chr15:74071509..77878298 [GRCh38]
Chr15:15q24.1-24.3
likely pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4313 COSMIC
Ensembl Genes ENSG00000284385 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580760 ENTREZGENE
GTEx ENSG00000284385 GTEx
HGNC ID HGNC:38310 ENTREZGENE
Human Proteome Map MIR4313 Human Proteome Map
miRBase MI0015843 ENTREZGENE
NCBI Gene 100423035 ENTREZGENE
PharmGKB PA165479189 PharmGKB
RNAcentral URS000075A0F0 RNACentral
  URS000075BE25 RNACentral