DRD4 (dopamine receptor D4) - Rat Genome Database

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Gene: DRD4 (dopamine receptor D4) Canis lupus familiaris
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Symbol: DRD4
Name: dopamine receptor D4
RGD ID: 40921726
Description: ENCODES a protein that exhibits dopamine binding (ortholog); dopamine neurotransmitter receptor activity (ortholog); dopamine neurotransmitter receptor activity, coupled via Gi/Go (ortholog); INVOLVED IN adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); adult locomotory behavior (ortholog); arachidonic acid secretion (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; excitatory synaptic transmission pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amphetamine abuse (ortholog); antisocial personality disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: D(4) dopamine receptor; LOW QUALITY PROTEIN: D(4) dopamine receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1825,378,476 - 25,381,179 (+)NCBI
ROS_Cfam_1.01826,314,100 - 26,316,803 (+)NCBI
UMICH_Zoey_3.11825,823,586 - 25,826,358 (+)NCBI
UNSW_CanFamBas_1.01825,468,566 - 25,471,386 (+)NCBI
UU_Cfam_GSD_1.01826,081,003 - 26,083,706 (+)NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (ISO)
adult locomotory behavior  (ISO)
arachidonic acid secretion  (ISO)
associative learning  (ISO)
behavioral fear response  (ISO)
behavioral response to cocaine  (ISO)
circadian rhythm  (ISO)
dopamine receptor signaling pathway  (ISO)
fear response  (ISO)
inhibitory postsynaptic potential  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of synaptic transmission  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of voltage-gated calcium channel activity  (ISO)
olfactory learning  (ISO)
photoperiodism  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of kinase activity  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of penile erection  (ISO)
positive regulation of sodium:proton antiporter activity  (ISO)
regulation of calcium-mediated signaling  (ISO)
regulation of circadian rhythm  (ISO)
regulation of dopamine metabolic process  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of postsynaptic membrane neurotransmitter receptor levels  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to histamine  (ISO)
response to steroid hormone  (ISO)
retina development in camera-type eye  (ISO)
short-term memory  (ISO)
synaptic transmission, dopaminergic  (ISO)

References
Additional References at PubMed
PMID:23713429  


Genomics

Comparative Map Data
DRD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1825,378,476 - 25,381,179 (+)NCBI
ROS_Cfam_1.01826,314,100 - 26,316,803 (+)NCBI
UMICH_Zoey_3.11825,823,586 - 25,826,358 (+)NCBI
UNSW_CanFamBas_1.01825,468,566 - 25,471,386 (+)NCBI
UU_Cfam_GSD_1.01826,081,003 - 26,083,706 (+)NCBI
DRD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11637,269 - 640,706 (+)EnsemblGRCh38hg38GRCh38
GRCh3811637,269 - 640,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711637,269 - 640,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611627,305 - 630,703 (+)NCBINCBI36hg18NCBI36
Build 3411627,304 - 630,703NCBI
Celera11702,422 - 705,821 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11452,513 - 456,039 (+)NCBIHuRef
CHM1_111636,234 - 639,634 (+)NCBICHM1_1
Drd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,871,887 - 140,876,377 (+)NCBIGRCm39mm39
GRCm39 Ensembl7140,871,919 - 140,876,377 (+)Ensembl
GRCm387141,291,974 - 141,296,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,292,006 - 141,296,464 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,477,905 - 148,480,900 (+)NCBIGRCm37mm9NCBIm37
MGSCv367141,143,326 - 141,146,321 (+)NCBImm8
Celera7141,085,754 - 141,088,749 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.6NCBI
Drd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21196,396,366 - 196,400,824 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1196,396,366 - 196,399,553 (+)Ensembl
Rnor_6.01214,278,296 - 214,282,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,278,296 - 214,281,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,195,844 - 221,200,366 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,485,597 - 201,488,784 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,636,931 - 201,640,119 (+)NCBI
Celera1194,030,237 - 194,033,424 (+)NCBICelera
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
Drd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,424,411 - 11,426,960 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,424,347 - 11,426,962 (-)NCBIChiLan1.0ChiLan1.0
DRD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111671,445 - 674,412 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v011640,401 - 646,775 (+)NCBIMhudiblu_PPA_v0panPan3
Drd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947468,387 - 471,254 (+)NCBI
SpeTri2.0NW_004936888468,334 - 471,254 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2398,766 - 401,432 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12398,766 - 401,539 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22272,619 - 275,757 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11454,018 - 459,582 (+)NCBI
Vero_WHO_p1.0NW_02366603897,516,746 - 97,520,656 (+)NCBI
Drd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,834,093 - 21,837,314 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_038424041   ⟹   XP_038279969
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01826,314,100 - 26,316,803 (+)NCBI
RefSeq Acc Id: XM_038454403   ⟹   XP_038310331
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1825,378,476 - 25,381,179 (+)NCBI
RefSeq Acc Id: XM_038500400   ⟹   XP_038356328
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11825,823,586 - 25,826,358 (+)NCBI
RefSeq Acc Id: XM_038562962   ⟹   XP_038418890
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01826,081,003 - 26,083,706 (+)NCBI
RefSeq Acc Id: XM_038627083   ⟹   XP_038483011
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01825,468,566 - 25,471,386 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_038356328   ⟸   XM_038500400
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038483011   ⟸   XM_038627083
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038279969   ⟸   XM_038424041
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038310331   ⟸   XM_038454403
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038418890   ⟸   XM_038562962
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
NCBI Gene DRD4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 DRD4  dopamine receptor D4  DRD4  dopamine receptor D4  Data Merged 737654 PROVISIONAL