DRD4 (dopamine receptor D4) - Rat Genome Database

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Gene: DRD4 (dopamine receptor D4) Canis lupus familiaris
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Symbol: DRD4
Name: dopamine receptor D4
RGD ID: 40921726
Description: ENCODES a protein that exhibits dopamine binding (ortholog); dopamine neurotransmitter receptor activity, coupled via Gi/Go (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); adult locomotory behavior (ortholog); associative learning (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; excitatory synaptic transmission pathway; ASSOCIATED WITH alcohol use disorder (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: D(4) dopamine receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1825,378,476 - 25,381,179 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,314,100 - 26,316,803 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,314,085 - 26,316,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,823,586 - 25,826,358 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,468,566 - 25,471,386 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,081,003 - 26,083,706 (+)NCBIUU_Cfam_GSD_1.0


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,IEA,ISO)
adult locomotory behavior  (IEA,ISO)
arachidonate secretion  (IEA)
associative learning  (ISO)
behavioral fear response  (ISO)
behavioral response to cocaine  (IEA,ISO)
circadian rhythm  (ISO)
fear response  (IEA,ISO)
G protein-coupled dopamine receptor signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
inhibitory postsynaptic potential  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA)
modulation of inhibitory postsynaptic potential  (ISO)
negative regulation of cytosolic calcium ion concentration  (IBA)
negative regulation of protein secretion  (IEA)
negative regulation of synaptic transmission  (ISO)
negative regulation of synaptic transmission, GABAergic  (ISO)
negative regulation of synaptic transmission, glutamatergic  (IBA)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
olfactory learning  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IBA,IEA)
photoperiodism  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of penile erection  (ISO)
prepulse inhibition  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of calcium-mediated signaling  (ISO)
regulation of circadian rhythm  (IEA)
regulation of dopamine metabolic process  (IEA,ISO)
regulation of dopamine secretion  (IBA)
regulation of neurotransmitter secretion  (ISO)
regulation of postsynaptic membrane neurotransmitter receptor levels  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (IEA)
regulation of potassium ion transport  (IBA)
regulation of protein kinase A signaling  (ISO)
response to amphetamine  (IEA,ISO)
response to epinephrine  (ISO)
response to ethanol  (ISO)
response to histamine  (IEA)
response to light stimulus  (ISO)
response to steroid hormone  (ISO)
response to thyroid hormone  (ISO)
retina development in camera-type eye  (ISO)
short-term memory  (ISO)
synaptic transmission, dopaminergic  (IEA,ISO)

References
Additional References at PubMed
PMID:22301074   PMID:23713429   PMID:30032202  


Genomics

Comparative Map Data
DRD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1825,378,476 - 25,381,179 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,314,100 - 26,316,803 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,314,085 - 26,316,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,823,586 - 25,826,358 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,468,566 - 25,471,386 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,081,003 - 26,083,706 (+)NCBIUU_Cfam_GSD_1.0
DRD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811637,269 - 640,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11637,269 - 640,706 (+)EnsemblGRCh38hg38GRCh38
GRCh3711637,269 - 640,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611627,305 - 630,703 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411627,304 - 630,703NCBI
Celera11702,422 - 705,821 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11452,513 - 456,039 (+)NCBIHuRef
CHM1_111636,234 - 639,634 (+)NCBICHM1_1
T2T-CHM13v2.011685,792 - 689,369 (+)NCBIT2T-CHM13v2.0
Drd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,871,931 - 140,874,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,871,919 - 140,876,377 (+)EnsemblGRCm39 Ensembl
GRCm387141,291,974 - 141,296,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,292,006 - 141,296,464 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,477,905 - 148,480,900 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,143,326 - 141,146,321 (+)NCBIMGSCv36mm8
Celera7141,085,754 - 141,088,749 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.6NCBI
Drd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,825,937 - 205,829,124 (+)NCBIGRCr8
mRatBN7.21196,396,366 - 196,400,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,396,366 - 196,399,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,741,809 - 204,744,982 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,868,591 - 211,871,768 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,542,729 - 204,545,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,278,296 - 214,282,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,278,296 - 214,281,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,195,844 - 221,200,366 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,485,597 - 201,488,784 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,636,931 - 201,640,119 (+)NCBI
Celera1194,030,237 - 194,033,424 (+)NCBICelera
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
Drd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,424,411 - 11,426,960 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,424,347 - 11,426,962 (-)NCBIChiLan1.0ChiLan1.0
DRD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,007,058 - 3,019,627 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,222,678 - 2,235,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011640,401 - 646,775 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111671,445 - 674,412 (+)NCBIpanpan1.1PanPan1.1panPan2
Drd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947468,387 - 471,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888468,403 - 471,205 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888468,334 - 471,254 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2398,766 - 402,433 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12398,766 - 401,539 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22272,619 - 275,757 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11454,018 - 459,582 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603897,516,746 - 97,520,656 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,834,169 - 21,836,710 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,834,093 - 21,837,314 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845030767   ⟹   ENSCAFP00845024128
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1826,314,085 - 26,316,803 (+)Ensembl
RefSeq Acc Id: XM_038424041   ⟹   XP_038279969
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01826,314,100 - 26,316,803 (+)NCBI
RefSeq Acc Id: XM_038454403   ⟹   XP_038310331
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1825,378,476 - 25,381,179 (+)NCBI
RefSeq Acc Id: XM_038500400   ⟹   XP_038356328
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11825,823,586 - 25,826,358 (+)NCBI
RefSeq Acc Id: XM_038562962   ⟹   XP_038418890
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01826,081,003 - 26,083,706 (+)NCBI
RefSeq Acc Id: XM_038627083   ⟹   XP_038483011
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01825,468,566 - 25,471,386 (+)NCBI
RefSeq Acc Id: XP_038356328   ⟸   XM_038500400
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038483011   ⟸   XM_038627083
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038279969   ⟸   XM_038424041
- Peptide Label: isoform X1
- UniProtKB: Q589Y6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310331   ⟸   XM_038454403
- Peptide Label: isoform X1
- UniProtKB: Q589Y6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418890   ⟸   XM_038562962
- Peptide Label: isoform X1
- UniProtKB: Q589Y6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845024128   ⟸   ENSCAFT00845030767
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000050649 UniProtKB/TrEMBL
  ENSCAFG00845017368 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000097913.1 UniProtKB/TrEMBL
  ENSCAFT00845030767 ENTREZGENE
  ENSCAFT00845030767.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Dopamine_D4_rcpt UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene DRD4 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24248:SF143 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS DOPAMINED4R UniProtKB/TrEMBL
  DOPAMINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I3P2A8_CANLF UniProtKB/TrEMBL
  A0A8P0PQ91_CANLF UniProtKB/TrEMBL
  Q589Y6 ENTREZGENE, UniProtKB/TrEMBL
  Q76FN9_CANLF UniProtKB/TrEMBL
  Q76FP0_CANLF UniProtKB/TrEMBL
  Q76FP1_CANLF UniProtKB/TrEMBL
  Q9GKX3_CANLF UniProtKB/TrEMBL
  Q9GKX4_CANLF UniProtKB/TrEMBL
  Q9GKX5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:110590 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 DRD4  dopamine receptor D4  DRD4  dopamine receptor D4  Data merged from RGD:15036872 737654 PROVISIONAL