DROSHA (drosha ribonuclease III) - Rat Genome Database

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Gene: DROSHA (drosha ribonuclease III) Canis lupus familiaris
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Symbol: DROSHA
Name: drosha ribonuclease III
RGD ID: 40909839
Description: ENCODES a protein that exhibits DEAD/H-box RNA helicase binding (inferred); double-stranded RNA binding (inferred); endonuclease activity (inferred); INVOLVED IN miRNA metabolic process (ortholog); pre-miRNA processing (ortholog); regulation of gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH esophageal atresia (ortholog); genetic disease (ortholog); hepatoblastoma (ortholog); FOUND IN glutamatergic synapse (ortholog); microprocessor complex (ortholog); postsynaptic density (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ribonuclease 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha475,406,973 - 75,528,472 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0476,334,752 - 76,456,036 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl476,334,773 - 76,456,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1476,027,994 - 76,149,740 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0476,157,564 - 76,278,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0476,685,947 - 76,807,515 (+)NCBIUU_Cfam_GSD_1.0


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DROSHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha475,406,973 - 75,528,472 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0476,334,752 - 76,456,036 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl476,334,773 - 76,456,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1476,027,994 - 76,149,740 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0476,157,564 - 76,278,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0476,685,947 - 76,807,515 (+)NCBIUU_Cfam_GSD_1.0
DROSHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38531,400,494 - 31,532,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl531,400,494 - 31,532,196 (-)EnsemblGRCh38hg38GRCh38
GRCh37531,400,601 - 31,532,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36531,436,358 - 31,568,039 (-)NCBINCBI36Build 36hg18NCBI36
Celera531,281,095 - 31,412,752 (-)NCBICelera
Cytogenetic Map5p13.3NCBI
HuRef531,368,999 - 31,500,422 (-)NCBIHuRef
CHM1_1531,402,053 - 31,533,647 (-)NCBICHM1_1
T2T-CHM13v2.0531,514,128 - 31,645,804 (-)NCBIT2T-CHM13v2.0
Drosha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391512,824,893 - 12,935,377 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1512,824,901 - 12,935,377 (+)EnsemblGRCm39 Ensembl
GRCm381512,824,804 - 12,935,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1512,824,815 - 12,935,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv371512,754,570 - 12,865,046 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361512,778,615 - 12,879,971 (+)NCBIMGSCv36mm8
Celera1512,603,657 - 12,710,691 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.99NCBI
Drosha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8263,591,885 - 63,703,688 (+)NCBIGRCr8
mRatBN7.2261,864,886 - 61,976,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl261,864,970 - 61,976,688 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx268,993,506 - 69,106,954 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0267,116,207 - 67,229,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0262,117,683 - 62,231,110 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0262,887,267 - 63,000,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl262,887,267 - 62,999,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0281,692,120 - 81,804,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4262,336,007 - 62,447,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1262,264,382 - 62,375,798 (+)NCBI
Celera256,722,605 - 56,834,195 (-)NCBICelera
Cytogenetic Map2q16NCBI
Drosha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542617,387,534 - 17,502,294 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542617,387,595 - 17,505,126 (-)NCBIChiLan1.0ChiLan1.0
DROSHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2478,786,664 - 78,917,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1576,940,301 - 77,071,537 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0578,813,923 - 78,945,149 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1584,191,596 - 84,322,590 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl584,194,546 - 84,322,310 (+)Ensemblpanpan1.1panPan2
Drosha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213222,153,551 - 222,271,819 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365189,106,142 - 9,219,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365189,100,094 - 9,218,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DROSHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1617,565,137 - 17,848,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11617,727,695 - 17,847,954 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21618,544,660 - 18,667,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DROSHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1430,665,759 - 30,807,047 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl430,665,131 - 30,795,442 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607120,896,595 - 21,030,930 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drosha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475922,949,150 - 23,082,487 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475922,949,225 - 23,082,263 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCAFT00845004381   ⟹   ENSCAFP00845003502
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl476,334,773 - 76,456,039 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004395   ⟹   ENSCAFP00845003514
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl476,334,791 - 76,456,018 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004409   ⟹   ENSCAFP00845003524
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl476,334,831 - 76,455,875 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004606   ⟹   ENSCAFP00845003681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl476,334,832 - 76,456,026 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004626   ⟹   ENSCAFP00845003697
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl476,334,832 - 76,456,026 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004688   ⟹   ENSCAFP00845003743
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl476,334,832 - 76,456,018 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004707   ⟹   ENSCAFP00845003760
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl476,337,739 - 76,456,027 (+)Ensembl
RefSeq Acc Id: XM_038474280   ⟹   XP_038330208
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1476,027,994 - 76,149,740 (+)NCBI
RefSeq Acc Id: XM_038500608   ⟹   XP_038356536
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha475,406,973 - 75,528,472 (+)NCBI
RefSeq Acc Id: XM_038535408   ⟹   XP_038391336
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0476,685,947 - 76,807,515 (+)NCBI
RefSeq Acc Id: XM_038599682   ⟹   XP_038455610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0476,157,564 - 76,278,792 (+)NCBI
RefSeq Acc Id: XM_038663996   ⟹   XP_038519924
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0476,334,755 - 76,456,036 (+)NCBI
RefSeq Acc Id: XM_038663997   ⟹   XP_038519925
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0476,334,755 - 76,456,036 (+)NCBI
RefSeq Acc Id: XM_038663998   ⟹   XP_038519926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0476,334,754 - 76,456,036 (+)NCBI
RefSeq Acc Id: XM_038663999   ⟹   XP_038519927
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0476,334,755 - 76,456,036 (+)NCBI
RefSeq Acc Id: XM_038664000   ⟹   XP_038519928
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0476,334,755 - 76,456,036 (+)NCBI
RefSeq Acc Id: XR_005426248
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0476,334,752 - 76,456,036 (+)NCBI
RefSeq Acc Id: XP_038330208   ⟸   XM_038474280
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038455610   ⟸   XM_038599682
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038519926   ⟸   XM_038663998
- Peptide Label: isoform X3
- UniProtKB: A0A8I3MJP3 (UniProtKB/TrEMBL),   A0A8P0NNE2 (UniProtKB/TrEMBL),   A0A8I3MFR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519924   ⟸   XM_038663996
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MFR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519928   ⟸   XM_038664000
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L4X3 (UniProtKB/TrEMBL),   A0A8I3MLA6 (UniProtKB/TrEMBL),   A0A8P0PLU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519927   ⟸   XM_038663999
- Peptide Label: isoform X4
- UniProtKB: A0A8I3MTB2 (UniProtKB/TrEMBL),   A0A8P0PNK5 (UniProtKB/TrEMBL),   A0A8C0NN88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519925   ⟸   XM_038663997
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MFR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038356536   ⟸   XM_038500608
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L4X3 (UniProtKB/TrEMBL),   A0A8I3MLA6 (UniProtKB/TrEMBL),   A0A8P0PLU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391336   ⟸   XM_038535408
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L4X3 (UniProtKB/TrEMBL),   A0A8I3MLA6 (UniProtKB/TrEMBL),   A0A8P0PLU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003524   ⟸   ENSCAFT00845004409
RefSeq Acc Id: ENSCAFP00845003697   ⟸   ENSCAFT00845004626
RefSeq Acc Id: ENSCAFP00845003743   ⟸   ENSCAFT00845004688
RefSeq Acc Id: ENSCAFP00845003514   ⟸   ENSCAFT00845004395
RefSeq Acc Id: ENSCAFP00845003681   ⟸   ENSCAFT00845004606
RefSeq Acc Id: ENSCAFP00845003502   ⟸   ENSCAFT00845004381
RefSeq Acc Id: ENSCAFP00845003760   ⟸   ENSCAFT00845004707
Protein Domains
DRBM   RNase III


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018939 UniProtKB/TrEMBL
  ENSCAFG00030017372 UniProtKB/TrEMBL
  ENSCAFG00040013772 UniProtKB/TrEMBL
  ENSCAFG00845002476 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000045678.3 UniProtKB/TrEMBL
  ENSCAFT00000104536.1 UniProtKB/TrEMBL
  ENSCAFT00000105225.1 UniProtKB/TrEMBL
  ENSCAFT00030032058.1 UniProtKB/TrEMBL
  ENSCAFT00030032357.1 UniProtKB/TrEMBL
  ENSCAFT00030032557.1 UniProtKB/TrEMBL
  ENSCAFT00030032840.1 UniProtKB/TrEMBL
  ENSCAFT00030033124.1 UniProtKB/TrEMBL
  ENSCAFT00040025424.1 UniProtKB/TrEMBL
  ENSCAFT00040025610.1 UniProtKB/TrEMBL
  ENSCAFT00845004381.1 UniProtKB/TrEMBL
  ENSCAFT00845004395 ENTREZGENE
  ENSCAFT00845004395.1 UniProtKB/TrEMBL
  ENSCAFT00845004409 ENTREZGENE
  ENSCAFT00845004409.1 UniProtKB/TrEMBL
  ENSCAFT00845004606 ENTREZGENE
  ENSCAFT00845004606.1 UniProtKB/TrEMBL
  ENSCAFT00845004626.1 UniProtKB/TrEMBL
  ENSCAFT00845004688 ENTREZGENE
  ENSCAFT00845004688.1 UniProtKB/TrEMBL
  ENSCAFT00845004707.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1520.10 UniProtKB/TrEMBL
  3.30.160.20 UniProtKB/TrEMBL
InterPro dsRBD_dom UniProtKB/TrEMBL
  RNase_III UniProtKB/TrEMBL
  RNase_III_dom UniProtKB/TrEMBL
  RNAse_III_DSRM__animal UniProtKB/TrEMBL
  RNase_III_sf UniProtKB/TrEMBL
NCBI Gene DROSHA ENTREZGENE
PANTHER PTHR11207 UniProtKB/TrEMBL
  RIBONUCLEASE 3 UniProtKB/TrEMBL
Pfam dsrm UniProtKB/TrEMBL
  Ribonucleas_3_3 UniProtKB/TrEMBL
  Ribonuclease_3 UniProtKB/TrEMBL
PROSITE DS_RBD UniProtKB/TrEMBL
  RNASE_3_1 UniProtKB/TrEMBL
  RNASE_3_2 UniProtKB/TrEMBL
SMART DSRM UniProtKB/TrEMBL
  RIBOc UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
  SSF69065 UniProtKB/TrEMBL
UniProt A0A8C0L4X3 ENTREZGENE
  A0A8C0NN88 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NPD1_CANLF UniProtKB/TrEMBL
  A0A8C0RMI5_CANLF UniProtKB/TrEMBL
  A0A8C0SIH4_CANLF UniProtKB/TrEMBL
  A0A8C0SL36_CANLF UniProtKB/TrEMBL
  A0A8I3MFR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MJP3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3ML97_CANLF UniProtKB/TrEMBL
  A0A8I3MLA6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MNJ0_CANLF UniProtKB/TrEMBL
  A0A8I3MTB2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2U6_CANLF UniProtKB/TrEMBL
  A0A8P0NNE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PLU7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PNK5 ENTREZGENE, UniProtKB/TrEMBL