Kiss1<sup>tm1Nips</sup> (KiSS-1 metastasis-suppressor; targeted mutant 1, Nips) - Rat Genome Database

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Gene: Kiss1tm1Nips (KiSS-1 metastasis-suppressor; targeted mutant 1, Nips) Rattus norvegicus
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Symbol: Kiss1tm1Nips
Name: KiSS-1 metastasis-suppressor; targeted mutant 1, Nips
RGD ID: 40902862
Description: This mutation was made by electroporation of WDB/Nips-ES1/Nips (RGD ID:10054010) embryonic stem cells with a targeting vector. Homologous recombination of the rKiss1 targeting construct (13.4kb) result in the deletion of 2.5 kb of the Kiss1 locus, consisting of 88 bp of the first coding exon, all of the 2.0-kb downstream intron, and 319 bp of the second coding exon, covering all of the coding region of this exon including the key active region of the processed peptide.
ASSOCIATED WITH absent sexual maturation; decreased circulating luteinizing hormone level
Type: allele  of Kiss1  
Previously known as: Kiss1^[tm1Nips]
Is Marker For: Strains:   WI;WDB-Kiss1tm1Nips  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Lack of pulse and surge modes and glutamatergic stimulation of luteinising hormone release in Kiss1 knockout rats. Uenoyama Y, etal., J Neuroendocrinol. 2015 Mar;27(3):187-97. doi: 10.1111/jne.12257.

Genomics


Related Rat Strains
The following Strains have been annotated to Kiss1tm1Nips
WI;WDB-Kiss1tm1Nips    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information