Gipc1 (GIPC PDZ domain containing family, member 1) - Rat Genome Database

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Gene: Gipc1 (GIPC PDZ domain containing family, member 1) Mus musculus
Analyze
Symbol: Gipc1
Name: GIPC PDZ domain containing family, member 1
RGD ID: 407571016
MGI Page MGI
Description: Enables actin binding activity; identical protein binding activity; and myosin binding activity. Involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in several cellular components, including dendrite; synaptic vesicle; and vesicle membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including future brain; genitourinary system; hemolymphoid system gland; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 2. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GAIP C-terminus-interacting protein; GIPC; Glut1CIP; neurophilin1-IP; PDZ domain-containing protein GIPC1; regulator of G-protein signaling 19 interacting protein 1; RGS-GAIP interacting protein GIPC; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Rgs19ip1; semaF cytoplasmic domain associated protein; semaF cytoplasmic domain-associated protein 1; SEMCAP-1; Semcap1; synectin; Tax interacting protein, clone 2; TaxIP2; TIP-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,376,037 - 84,391,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,379,306 - 84,391,323 (+)EnsemblGRCm39 Ensembl
GRCm38883,649,408 - 83,664,789 (+)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9770488   PMID:10318831   PMID:10349636   PMID:10414980   PMID:10827173   PMID:10911369   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11342430   PMID:11546783  
PMID:11751850   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15527962   PMID:15782199   PMID:15975910   PMID:15978582   PMID:16141072  
PMID:16141073   PMID:16467373   PMID:16602821   PMID:16740480   PMID:16819522   PMID:16908842   PMID:16940428   PMID:17576142   PMID:17967808   PMID:18723443   PMID:18775991   PMID:18799693  
PMID:18824598   PMID:19235722   PMID:19581409   PMID:20434959   PMID:20634288   PMID:21543326   PMID:21677750   PMID:21871877   PMID:22991442   PMID:23884936   PMID:23897694   PMID:24498314  
PMID:26013465   PMID:26265212   PMID:28190767   PMID:28224988   PMID:28289053   PMID:28537552   PMID:28671696   PMID:29581031   PMID:32325033   PMID:33500317   PMID:34705526   PMID:38186571  
PMID:38458410  


Genomics

Comparative Map Data
Gipc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,376,037 - 84,391,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,379,306 - 84,391,323 (+)EnsemblGRCm39 Ensembl
GRCm38883,649,408 - 83,664,789 (+)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
GIPC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,477,762 - 14,496,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,477,760 - 14,496,149 (-)EnsemblGRCh38hg38GRCh38
GRCh371914,588,574 - 14,606,939 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,449,571 - 14,467,944 (-)NCBINCBI36Build 36hg18NCBI36
Build 341914,449,571 - 14,467,944NCBI
Celera1914,482,692 - 14,501,043 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,158,686 - 14,177,001 (-)NCBIHuRef
CHM1_11914,588,560 - 14,606,924 (-)NCBICHM1_1
T2T-CHM13v2.01914,604,395 - 14,622,744 (-)NCBIT2T-CHM13v2.0
Gipc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,380,125 - 41,392,078 (-)NCBIGRCr8
mRatBN7.21924,474,291 - 24,487,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,453,123 - 24,486,997 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,296,524 - 31,300,339 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,950,945 - 31,954,760 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,173,772 - 34,177,589 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,786,604 - 24,798,231 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,786,628 - 24,798,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,765,772 - 35,778,495 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,165,658 - 26,177,206 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11926,170,483 - 26,174,300 (-)NCBI
Celera1924,018,366 - 24,029,872 (-)NCBICelera
Cytogenetic Map19q11NCBI
Gipc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541533,067,689 - 33,074,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541533,067,689 - 33,077,749 (-)NCBIChiLan1.0ChiLan1.0
GIPC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,407,561 - 19,425,899 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,409,821 - 18,428,123 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,041,192 - 14,059,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,884,529 - 14,897,247 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,885,185 - 14,889,701 (-)Ensemblpanpan1.1panPan2
GIPC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,144,076 - 48,155,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,150,498 - 48,157,191 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,020,555 - 48,030,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,660,996 - 48,673,506 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,661,602 - 48,678,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12047,874,912 - 47,885,049 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,301,291 - 48,311,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,544,132 - 48,554,244 (+)NCBIUU_Cfam_GSD_1.0
Gipc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,324,418 - 207,334,872 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366593,012,012 - 3,026,883 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366593,019,829 - 3,030,280 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GIPC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,780,442 - 64,794,919 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1264,780,447 - 64,794,922 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,158,635 - 65,174,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GIPC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,136,647 - 13,155,259 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,136,624 - 13,142,002 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660746,500,986 - 6,519,302 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gipc1
1375 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88079340489740987Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_018771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF089818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF104358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NM_018771   ⟹   NP_061241
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,379,307 - 84,391,418 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030243739   ⟹   XP_030099599
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,376,037 - 84,391,313 (+)NCBI
Sequence:
RefSeq Acc Id: XP_030099599   ⟸   XM_030243739
- Peptide Label: isoform X1
- UniProtKB: Q9Z0G0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_061241   ⟸   NM_018771
- UniProtKB: Q9Z0G0 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
PDZ

Promoters
RGD ID:8667611
Promoter ID:EPDNEW_M11837
Type:initiation region
Name:Gipc1_1
Description:Mus musculus GIPC PDZ domain containing family, member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38883,652,701 - 83,652,761EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSMUSG00000019433 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019577 ENTREZGENE
  ENSMUST00000019577.10 UniProtKB/Swiss-Prot
  ENSMUST00000211985.2 UniProtKB/TrEMBL
  ENSMUST00000212463.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GIPC1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67903 UniProtKB/Swiss-Prot
MGD MGI:1926252 ENTREZGENE
NCBI Gene Gipc1 ENTREZGENE
PANTHER PDZ DOMAIN-CONTAINING PROTEIN GIPC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS-GAIP INTERACTING PROTEIN GIPC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gipc1 PhenoGen
PIRSF UCP038083_GIPC UniProtKB/Swiss-Prot
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PDZ domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RML2_MOUSE UniProtKB/TrEMBL
  A0A1D5RMN2_MOUSE UniProtKB/TrEMBL
  GIPC1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE