Ahr<sup>em1Iexas</sup> (aryl hydrocarbon receptor; CRISPR/Cas9 induced mutant1, Iexas) - Rat Genome Database

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Gene: Ahrem1Iexas (aryl hydrocarbon receptor; CRISPR/Cas9 induced mutant1, Iexas) Rattus norvegicus
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Symbol: Ahrem1Iexas
Name: aryl hydrocarbon receptor; CRISPR/Cas9 induced mutant1, Iexas
RGD ID: 401940199
Description: The allele was created using CRISPR/Cas9 gene editing to delete 10 bp of exon 2 of Ahr in Sprague Dawley rats .
ASSOCIATED WITH increased right ventricle systolic pressure; pulmonary hypertension; ASSOCIATED WITH pulmonary hypertension
Type: allele  of Ahr  
Previously known as: Ahr^[em1Iexas]
Is Marker For: Strains:   SD-Ahrem1Iexas+/-   SD-Ahrem1Iexas-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension. Masaki T, etal., Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2023899118. doi: 10.1073/pnas.2023899118.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ahrem1Iexas-var1 chr6 52263461 52263470 AGTTAGACCG - deletion mRatBN7.2

Related Rat Strains
The following Strains have been annotated to Ahrem1Iexas
SD-Ahrem1Iexas+/-     SD-Ahrem1Iexas-/-    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information