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Gene: Tmdd1 (transmembrane and death domain 1) Mus musculus

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Symbol:

Tmdd1

Name:

transmembrane and death domain 1

RGD ID:

39130619

MGI Page

MGI

Description:

Orthologous to human TMDD1 (transmembrane and death domain 1).

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Gm47841; LOC118568222; transmembrane and death domain protein 1; transmembrane and death domain protein 1-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	100,944,178 - 100,945,335 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	100,944,223 - 100,945,278 (-)	Ensembl		GRCm39 Ensembl
Cytogenetic Map	15	F1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

References

Genomics

Comparative Map Data

Tmdd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	100,944,178 - 100,945,335 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	100,944,223 - 100,945,278 (-)	Ensembl		GRCm39 Ensembl
Cytogenetic Map	15	F1	NCBI

TMDD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	51,813,921 - 51,814,925 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	51,813,921 - 51,814,925 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	52,207,705 - 52,208,709 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	12	q13.13	NCBI
T2T-CHM13v2.0	12	51,777,441 - 51,778,451 (-)	NCBI		T2T-CHM13v2.0

Tmdd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	134,035,395 - 134,036,497 (-)	NCBI		GRCr8
mRatBN7.2	7	132,156,661 - 132,157,763 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	7	133,958,291 - 133,959,393 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	136,187,807 - 136,188,909 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	136,098,569 - 136,099,671 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Cytogenetic Map	7	q36	NCBI

TMDD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	42,377,489 - 42,384,679 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	42,375,382 - 42,381,443 (+)	NCBI		NHGRI_mPanPan1

TMDD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	27	43,085,526 - 43,086,491 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	3,166,739 - 3,167,704 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	27	3,183,547 - 3,184,512 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	3,169,533 - 3,170,514 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	43,483,865 - 43,484,854 (-)	NCBI		UU_Cfam_GSD_1.0

Tmdd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	63,877,561 - 63,883,868 (+)	NCBI		HiC_Itri_2

TMDD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666037	198,104,097 - 198,105,790 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Tmdd1
35 total Variants

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300627	Sluc26_m	susceptibility to lung cancer 26 (mouse)			Not determined		15	70345653	104073951	Mouse
1357526	Hyplip2_m	hyperlipidemia 2 (mouse)			Not determined		15	12402203	102896555	Mouse
11528547	Sluc34_m	susceptibility to lung cancer 34 (mouse)					15	97884933	102896555	Mouse
1301918	Skull22_m	skull morphology 22 (mouse)			Not determined		15	85901546	104073951	Mouse
14928306	Manh79_m	mandible shape 79 (mouse)					15	78847557	104073951	Mouse
1357894	Epfpq3_m	epididymal fat percentage QTL 3 (mouse)			Not determined		15	78601103	102901704	Mouse
26884425	Cvht2_m	cranial vault height 2, 5 week (mouse)					15	28800146	102008435	Mouse
4142060	W3q6_m	weight 3 weeks QTL 6 (mouse)			Not determined			78601103	102901704	Mouse
12791003	Aath8_m	aortic arch atherosclerosis 8 (mouse)					15	73430144	104073951	Mouse
11530038	Sluc34b_m	susceptibility to lung cancer 34b (mouse)					15	85896437	104073951	Mouse
11530037	Sluc34a_m	susceptibility to lung cancer 34a (mouse)					15	85896437	104073951	Mouse
1558985	Eae32_m	experimental allergic encephalomyelitis susceptibility 32 (mouse)			Not determined		15	32578416	103425899	Mouse
4141921	Pstc3_m	periosteal circumference 3 (mouse)			Not determined		15	67270698	101270847	Mouse
12880411	V125Dq11_m	vitamin D active form serum level QTL 11 (mouse)					15	78897881	104073951	Mouse
1300851	Heal4_m	wound healing/regeneration 4 (mouse)			Not determined		15	77527592	104073951	Mouse
14747011	Mancz13_m	mandible centroid size 13 (mouse)					15	72382669	104073951	Mouse
10402490	Dipa5_m	drug induced psychomotor activation 5 (mouse)			Not determined		15	79163411	104073951	Mouse
1300726	Pitm4_m	prion incubation time 4 (mouse)			Not determined		15	70349271	104073951	Mouse
1302197	Bhr2_m	bronchial hyperresponsiveness 2 (mouse)			Not determined		15	64306334	103425899	Mouse
1302074	Bmd4_m	bone mineral density 4 (mouse)			Not determined		15	56186708	103425899	Mouse
4141902	Cia37_m	collagen induced arthritis 37 (mouse)			Not determined		15	80884933	104073951	Mouse
14700689	Carg5_m	Candida albicans resistance gene 5 (mouse)					15	97697881	103008427	Mouse
4141581	Dshv1_m	dorsal hippocampal volume 1 (mouse)			Not determined			92788640	103425899	Mouse
26884399	Humsd1_m	humerus midshaft diameter 1, 5 week (mouse)					15	48363396	101708435	Mouse
4141897	Imrfq2_m	immune response to Factor IX QTL 2 (mouse)			Not determined			79908940	104073951	Mouse
1301284	Cosz3_m	cocaine seizure 3 (mouse)			Not determined		15	80313634	104073951	Mouse
4141511	Gdcr1_m	glycerolphosphate dehydrogenase regulator 1 (mouse)			Not determined			82615474	104073951	Mouse
1357614	Bmca_m	bile mucin accumulation (mouse)			Not determined		15	85896437	104073951	Mouse
1300648	Dbsty4_m	diabesity 4 (mouse)			Not determined		15	70349271	104073951	Mouse
1300974	Pgia9_m	proteoglycan induced arthritis 9 (mouse)			Not determined		15	80884933	104073951	Mouse

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_036159691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC104834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000222611 ⟹ ENSMUSP00000152149

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	15	100,944,223 - 100,945,278 (-)	Ensembl

RefSeq Acc Id:

XM_036159691 ⟹ XP_036015584

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	15	100,944,178 - 100,945,335 (-)	NCBI

Sequence:

show sequence

AATCTCCAGTCTTGCAACAGAGCCTCGGCATTCGAAGCCCCTCCCTCAGGCCGAGTCATGGTGT
GGGCGCTGATCCTGGCCCTCTGTAACCGGTTGCTGCCCCTCACGAGCGCGCTGGACGCCATGGG
CCCCCACACAGCAGTCCGCCTGGCGGAACTGCTGACCCCCGAGGAGTGCAACCACTTTCGTTCA
CTCCTCGAGGTACCCGAGCCCGACCTGGACAAGGAGTTGGCCCGGTTATCTGAGGACTTGCTGG
CGACGCCCGAGCCACCCGCATCCCGGCGTGGGGCGCAGGACTCGGTGGGACAACAGCGGCGGGC
GGCAGCGGAGCTGGTCCGGCTATCTGCGGACCGGCGGGCAACGCCCGAGCCACCCACACCCTCG
CTTAGGGCGCAGGACTCGGTGGGAGAGCCGCTGCGGGCCACAACCGCGCAGGCTTCGGAGGGGA
GGGAGGGCACATCCGAGTCCAGTGAGGTTTCTGACCGCTGCCGCGAGGCGCTGGCAACCTGGTT
GGCCGCTCAGGCTCCGTCCCTGTCGTGGGACCGCGTGGCCCGAGCCCTACGGCGCAGTGGCCGC
CCGGATGTGGCACGGGAGCTGGCCAAGAACCTCCACCAGCAGGCGACGTTGCAGCTGCGGAGGA
CCGGCGCAAATTACCTGCAGCAACTCCTGGCCCCAGCCCCGGCCCCGGTCCCGGTCCCGGTCCC
CGCCCCCGTCCCGGGTCCCGCCCCCGGTCCCGCCAGGGTCCCTGTCCCGGCTCCGCGTGCTCGC
CGCGCCGCCGCCCCCGCGCCTGACTGGGACAAGCTGGATCTGATCATGGAGCGCCTGCCGCAGC
CCCCGTACACGCGCAGCCTCTCAGCCTGGGTGGGGCCGCTGGCGCTCGGCCTTTTTGCCGGCTT
CCTGGGAGCGCTGTGCACCGGGGCGCTGATCACCGTGCTCACGCTGTGGATCACCGGCGACAAC
CGCGACGACGACCCGGCGTGGCCTCGTGCCCGCGGCCAGGCCGCCGCCTCCCGGCCCAGGCCGG
CTCGGACGCCCTGCAGCTGGGAAACGGAGCCGCTCCTGCCTCGGTCCTGGGCGCCGCAGCCACC
CTTGCCCCTCTGCCCGTCTCTGTGAACCGCTTGACGGCGGCGCACCGCTATAAAGTTTCCTAAA
GCGGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_036015584	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000152149
	ENSMUSP00000152149.2

RefSeq Acc Id:	XP_036015584 ⟸ XM_036159691
- UniProtKB:	A0A1Y7VIT9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSMUSP00000152149 ⟸ ENSMUST00000222611

Protein Domains

Death

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A1Y7VIT9-F1-model_v2	AlphaFold	A0A1Y7VIT9	1-351	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:6097044	AgrOrtholog
Ensembl Genes	ENSMUSG00000113558	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000222611	ENTREZGENE
	ENSMUST00000222611.2	UniProtKB/TrEMBL
InterPro	Death_domain	UniProtKB/TrEMBL
MGD	MGI:6097044	ENTREZGENE
NCBI Gene	LOC118568222	ENTREZGENE
PhenoGen	Tmdd1	PhenoGen
PROSITE	DEATH_DOMAIN	UniProtKB/TrEMBL
UniProt	A0A1Y7VIT9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-06-15	Tmdd1	transmembrane and death domain 1	LOC118568222	transmembrane and death domain protein 1-like	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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