Sbe2 (Shh brain enhancer 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Sbe2 (Shh brain enhancer 2) Mus musculus
Analyze
Symbol: Sbe2
Name: Shh brain enhancer 2
RGD ID: 39128482
Description: This region contains a brain enhancer that regulates expression of the sonic hedgehog (Shh) gene, located approximately 410 kb downstream. This sequence is recognized by transcriptional regulators including Sox2 (SRY (sex determining region Y)-box 2). Binding of this enhancer by Sox2 is antagonized by T-box family transcription factors. [provided by RefSeq, Jul 2015]
Type: biological-region
RefSeq Status: REVIEWED
Previously known as: ECR1; Rr366624
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39529,080,458 - 29,081,630 (+)NCBIGRCm39GRCm39mm39
GRCm38528,875,460 - 28,876,632 (+)NCBIGRCm38GRCm38mm10GRCm38
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:16407397   PMID:18836447   PMID:22421044   PMID:23674600   PMID:24859115  


Genomics

Comparative Map Data
Sbe2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39529,080,458 - 29,081,630 (+)NCBIGRCm39GRCm39mm39
GRCm38528,875,460 - 28,876,632 (+)NCBIGRCm38GRCm38mm10GRCm38
SBE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387156,268,357 - 156,269,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377156,061,051 - 156,061,848 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map7q36NCBI
T2T-CHM13v2.07157,455,731 - 157,456,528 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Sbe2
53 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129421124Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NG_042252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information

Database Acc Id Source(s)
NCBI Gene Sbe2 ENTREZGENE
PhenoGen Sbe2 PhenoGen