greater CFTR locus negative regulatory element CR2
RGD ID:
38620261
Description:
This conserved genomic region, which is located in the greater CFTR locus on chromosome 7, can function as both a silencer and an enhancer-blocking element. In transfected K562 cells, it showed modest silencing for reporter constructs with an SV40 promoter coupled to the HS2 beta-globin enhancer, and also modest enhancer-blocking activity for constructs with a gamma-globin promoter and HS2 enhancer, when positioned between the enhancer and promoter. [provided by RefSeq, Sep 2018]