Cp<sup>em1Ang</sup> (ceruloplasmin; CRISPR/Cas9 induced mutant1, Ang) - Rat Genome Database

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Gene: Cpem1Ang (ceruloplasmin; CRISPR/Cas9 induced mutant1, Ang) Rattus norvegicus
Symbol: Cpem1Ang
Name: ceruloplasmin; CRISPR/Cas9 induced mutant1, Ang
RGD ID: 38501062
Description: The mutations created by CRISPR/Cas9 in the Crl:SD embryos contained a 54- bp deletion and a 2-bp insertion in exon1 of Cp, resulted a premature stop coden in exon 2. The sgRNAcr377 (TacGene, Paris, France) used targeted the exon 1 of Cp and had the following sequence: 59-GGAAT-TACTGAAGCAGTTT-39.
ASSOCIATED WITH decreased circulating ceruloplasmin level; decreased circulating copper level; decreased circulating iron level
Type: allele  of Cp  
Is Marker For: Strains:   SD-Cpem1Ang+/-   SD-Cpem1Ang-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Ceruloplasmin deficiency does not induce macrophagic iron overload: lessons from a new rat model of hereditary aceruloplasminemia. Kenawi M, etal., FASEB J. 2019 Dec;33(12):13492-13502. doi: 10.1096/fj.201901106R. Epub 2019 Sep 27.


Related Rat Strains
The following Strains have been annotated to Cpem1Ang



Nucleotide Sequences

Additional Information