Asmt (acetylserotonin O-methyltransferase)

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Gene: Asmt (acetylserotonin O-methyltransferase) Mus musculus

Analyze

Symbol:

Asmt

Name:

acetylserotonin O-methyltransferase

RGD ID:

3731974

MGI Page

MGI

Description:

Enables acetylserotonin O-methyltransferase activity. Acts upstream of or within melatonin biosynthetic process and negative regulation of male gonad development. Orthologous to human ASMT (acetylserotonin O-methyltransferase).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

ASMTY; Hio; Hiomt; HIOMTY; hydroxyindole O-methyltransfease; hydroxyindole O-methyltransferase; hydroxyindole-O-methyltransferase

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	169,106,379 - 169,111,787 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	169,106,356 - 169,111,844 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	170,672,644 - 170,678,054 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	170,672,644 - 170,678,054 (+)	Ensembl	GRCm38		mm10	GRCm38
Cytogenetic Map	X	F5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Wilson disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

acetamide (ISO)

acrylamide (ISO)

ammonium chloride (ISO)

aristolochic acid A (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

CGP 52608 (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

fenvalerate (ISO)

gentamycin (ISO)

propanal (ISO)

trichloroethene (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid metabolic process (IEA)

male gonad development (IMP)

melatonin biosynthetic process (IBA,IDA,IMP,ISO)

methylation (IBA)

negative regulation of male gonad development (IMP)

Molecular Function

acetylserotonin O-methyltransferase activity (IBA,IDA,IMP,ISO)

identical protein binding (ISO)

methyltransferase activity (IEA)

O-methyltransferase activity (IEA)

protein homodimerization activity (ISO)

S-adenosylmethionine-dependent methyltransferase activity (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

methionine cycle/metabolic pathway (ISO)

tryptophan metabolic pathway (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal pineal gland melatonin secretion (IAGP)

increased testis weight (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
2.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:3381630	PMID:3620949	PMID:3941912	PMID:7463037	PMID:8170356	PMID:20308563	PMID:20404168	PMID:21778461	PMID:21873635	PMID:23276394	PMID:24602487	PMID:29768727

Genomics

Comparative Map Data

Asmt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	169,106,379 - 169,111,787 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	169,106,356 - 169,111,844 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	170,672,644 - 170,678,054 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	170,672,644 - 170,678,054 (+)	Ensembl	GRCm38		mm10	GRCm38
Cytogenetic Map	X	F5	NCBI

ASMT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	Y	1,595,455 - 1,643,081 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38	X	1,595,455 - 1,643,081 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	X	1,615,059 - 1,643,081 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	1,714,348 - 1,761,974 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	Y	1,664,348 - 1,711,974 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	Y	1,674,348 - 1,721,974 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 36	X	1,674,348 - 1,721,974 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	Y	1,758,174 - 1,805,801	NCBI
Celera	X	5,992,483 - 6,035,986 (+)	NCBI		Celera
Cytogenetic Map	X	;Y	NCBI
CHM1_1	X	1,744,907 - 1,789,431 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	1,396,845 - 1,441,907 (+)	NCBI		T2T-CHM13v2.0
T2T-CHM13v2.0	Y	1,459,841 - 1,502,882 (+)	NCBI		T2T-CHM13v2.0

Asmt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	16,304,719 - 16,309,568 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	16,304,719 - 16,309,568 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	17,121,663 - 17,126,630 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	12	17,745,387 - 17,750,355 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	12	16,808,300 - 16,813,148 (-)	NCBI	Rnor_WKY
Rnor_6.0	12	18,521,383 - 18,527,036 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	18,521,401 - 18,526,250 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	20,506,337 - 20,511,600 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	16,811,892 - 16,817,186 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	16,841,819 - 16,847,116 (-)	NCBI
Celera	12	18,054,424 - 18,059,273 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

Asmt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955499	1,131,588 - 1,152,802 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955499	1,131,637 - 1,151,861 (+)	NCBI	ChiLan1.0	ChiLan1.0

ASMT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	X	1,737,699 - 1,772,983 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	1,749,371 - 1,772,916 (+)	Ensembl	panpan1.1		panPan2

ASMT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	1,012,952 - 1,025,684 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	1,012,961 - 1,025,263 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	957,221 - 969,532 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	927,859 - 940,066 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	927,859 - 940,057 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	919,275 - 931,589 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	936,207 - 948,529 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	972,568 - 984,887 (+)	NCBI		UU_Cfam_GSD_1.0

Asmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404953	666,394 - 669,387 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936644	3,707,365 - 3,708,601 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC110258194
(Sus scrofa - pig)

No map positions available.

LOC103232876
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	1,838 - 12,924 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666056	1,759,444 - 1,802,665 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Asmt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624834	747,233 - 757,071 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401118	Pgia39_m	proteoglycan induced arthritis 39 (mouse)			Not determined		X	144474380	169476592	Mouse
1302000	Pgia25_m	proteoglycan induced arthritis 2 (mouse)			Not determined		X	144474380	169476592	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001199212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001308488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB512670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB512671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB512672	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB512673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB512674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AEKQ02189142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MG954260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000178693 ⟹ ENSMUSP00000137135

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	X	169,106,356 - 169,111,844 (+)	Ensembl
GRCm38.p6 Ensembl	X	170,672,644 - 170,678,054 (+)	Ensembl

RefSeq Acc Id:

NM_001308488 ⟹ NP_001295417

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	X	169,106,379 - 169,111,787 (+)	NCBI
GRCm38	X	170,672,644 - 170,678,054 (+)	NCBI

Sequence:

show sequence

GGCTCAGCAGCTCGCGTCCCACGATGCACAGGGGCCGCTCGGCCTCCGCTCGCCAGGAGCGCGA
CTTCCGGGCCCTCATGGACCTGGCCCACGGCTTCATGGCCTCCCAGGTGCTGTTCGCGGGCTGC
GCGCTCCGCGTGTTCGACGCCGCGGCCCTGGGCCCCGTGGACGCCGCGGCGCTGGCGAGGTCGT
CGGGCCTGAGCCCCCGGGGGACGCGGCTGCTGCTCGACGCCTGCGCGGGGCTGGGGCTGCTGGG
GAGACGCAGGGGGGCGGGGCCGCGCGGCCCCGCCTACACCAACTCCCCCCTGGCGTCCACCTTC
CTGGTCGCGGGCAGCCCCCTGTCTCAGCGCAGCCTCCTGCTCTACCTGGCGGGCACCACCTACC
TGTGCTGGGGGCACCTGGCGGACGGCGTGAGGGAAGGGCGGAGCCAGTACGCGAGGGCCGTGGG
CGTCGACGCGGACGACCCCTTCACCGCCATCTACAGGTCGGAGGCCGAGCGCCTGCTGTTCATG
CGGGGCCTGCAGGAGACCTGGAGCCTGTGCGGGGGGCGGGTCCTCACGGCCTTCGACCTCTCGC
CCTTCAGGGTCATCTGCGACCTCGGTGGTGGGTCCGGGGCGCTGGCCCGCATGGCCGCCCGGCT
CTACCCGGGCAGCGAGGTCACCGTGTTCGAGACGCCCGACGTCGTCGCTGCCGCCCGCGCCCAC
TTCCCGCCCCCAGCGGACGAGGACGGGGCGGAGCCTCGTGTGTGCTTCCTGTCAGGCGACTTCT
TCCGCTCGCCGCTGCCGCCCGCCGACCTCTACGTCCTGGCCCGGGTCCTGCACGACTGGGCGGA
CGCCGCCTGCGTGGAGCTGCTGCGGCGCGTGCGGGGTGCCCTGCGGCCAGGCGGCGCGGTGCTG
CTGGTGGAGAGCGTGCTGTCCCCGGGAGGGGCGGGGCCGACGCGGACGCTGCTGCTGTCGCTCA
CGATGCTGCTGCAGGCCCGGGGCCGCGAGCGCACGGAGGCCGAGTACCGGGCGCTGACCGCGCG
TGCCGGCTTCTCCCGCCTGCGGCTGCGGCGCCCGCGGGGCCCCTACCACGCCATGATGGCCGCC
CGGGGGGGCGGGGCCGGGGCGCGGAGCGACGGCGGCGGCGGGGACGCGACGTCACAGACAGGAA
GTGGGACAGGAAGTGAGGTCGGCGCCCAGGACTGAGGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001186141	(Get FASTA)	NCBI Sequence Viewer
	NP_001295417	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAI82191	(Get FASTA)	NCBI Sequence Viewer
	BAI82192	(Get FASTA)	NCBI Sequence Viewer
	BAI82193	(Get FASTA)	NCBI Sequence Viewer
	BAI82194	(Get FASTA)	NCBI Sequence Viewer
	BAI82195	(Get FASTA)	NCBI Sequence Viewer
	D3KU66	(Get FASTA)	NCBI Sequence Viewer
	D3KU67	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001295417 ⟸ NM_001308488
- Peptide Label:	isoform 2
- UniProtKB:	D3KU66 (UniProtKB/Swiss-Prot), A0A0R4J285 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHRGRSASARQERDFRALMDLAHGFMASQVLFAGCALRVFDAAALGPVDAAALARSSGLSPRGT RLLLDACAGLGLLGRRRGAGPRGPAYTNSPLASTFLVAGSPLSQRSLLLYLAGTTYLCWGHLAD GVREGRSQYARAVGVDADDPFTAIYRSEAERLLFMRGLQETWSLCGGRVLTAFDLSPFRVICDL GGGSGALARMAARLYPGSEVTVFETPDVVAAARAHFPPPADEDGAEPRVCFLSGDFFRSPLPPA DLYVLARVLHDWADAACVELLRRVRGALRPGGAVLLVESVLSPGGAGPTRTLLLSLTMLLQARG RERTEAEYRALTARAGFSRLRLRRPRGPYHAMMAARGGGAGARSDGGGGDATSQTGSGTGSEVG AQD hide sequence

RefSeq Acc Id:

ENSMUSP00000137135 ⟸ ENSMUST00000178693

Protein Domains

Acetylserotonin O-methyltransferase dimerisation O-methyltransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3KU66-F1-model_v2	AlphaFold	D3KU66	1-387	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:96090	AgrOrtholog
Ensembl Genes	ENSMUSG00000093806	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000137135	ENTREZGENE
	ENSMUSP00000137135.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000178693	ENTREZGENE
	ENSMUST00000178693.4	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ASMT_dimerisation	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	O-MeTrfase_COMT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	O_MeTrfase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:107626	UniProtKB/Swiss-Prot
MGD	MGI:96090	ENTREZGENE
NCBI Gene	107626	ENTREZGENE
PANTHER	ACETYLSEROTONIN O-METHYLTRANSFERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11746	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Dimerisation2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Methyltransf_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Asmt	PhenoGen
PIRSF	O-mtase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
	SAM_OMT_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF53335	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0R4J285	ENTREZGENE, UniProtKB/TrEMBL
	ASMT_MOUSE	UniProtKB/Swiss-Prot
	D3KU65	ENTREZGENE
	D3KU66	ENTREZGENE
	D3KU67	ENTREZGENE
UniProt Secondary	D3KU65	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype