Slc14a2 (solute carrier family 14 member 2) - Rat Genome Database

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Gene: Slc14a2 (solute carrier family 14 member 2) Rattus norvegicus
Analyze
Symbol: Slc14a2
Name: solute carrier family 14 member 2 (Ensembl:solute carrier family 14 (urea transporter), member 2)
RGD ID: 3689
Description: Enables urea transmembrane transporter activity. Involved in response to water deprivation and urea transport. Located in apical plasma membrane. Orthologous to human SLC14A2 (solute carrier family 14 member 2); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (R)-noradrenaline; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: plasma membrane urea transporter; Slc14a1_v3; Slc14a1_v4; Slc14a2_v4; Slc14a2T; solute carrier family 14 (urea transporter), member 2; solute carrier family 14 (urea transporter), member 2, variant 4; solute carrier family 14 (urea transporter), member 2T; solute carrier family 14, member 2; testName; testSymbol; urea transport protein; Urea transporter; urea transporter 2; urea transporter UT-A2c; urea transporter UT-A2d; urea transporter, kidney; UrT1-C; UrT1-D; UT-A1; UT-A2; UT-A4; UTA3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Slc14a2_v1   Slc14a2_v2   Slc14a2_v3  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21871,612,460 - 72,039,462 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1871,612,460 - 71,792,968 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1873,711,878 - 74,138,787 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01874,381,161 - 74,808,122 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01872,237,749 - 72,664,708 (-)NCBIRnor_WKY
Rnor_6.01874,508,070 - 74,941,389 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,508,069 - 74,542,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,546,220 - 74,688,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01874,185,426 - 74,617,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41875,071,416 - 75,499,738 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11875,144,693 - 75,325,630 (-)NCBI
Celera1870,129,421 - 70,555,892 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular characterization of a novel UT-A urea transporter isoform (UT-A5) in testis. Fenton RA, etal., Am J Physiol Cell Physiol 2000 Nov;279(5):C1425-31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4. Karakashian A, etal., J Am Soc Nephrol 1999 Feb;10(2):230-7.
5. Expression of urea transporters in the developing rat kidney. Kim YH, etal., Am J Physiol Renal Physiol 2002 Mar;282(3):F530-40.
6. Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts. Klein JD, etal., J Am Soc Nephrol. 2006 Oct;17(10):2680-6. doi: 10.1681/ASN.2006030246. Epub 2006 Sep 7.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. Mistry AC, etal., J Biol Chem. 2007 Oct 12;282(41):30097-106. Epub 2007 Aug 16.
9. Cloning of the rat Slc14a2 gene and genomic organization of the UT-A urea transporter. Nakayama Y, etal., Biochim Biophys Acta 2001 Mar 19;1518(1-2):19-26.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts. Shayakul C, etal., Am J Physiol Renal Physiol 2001 Mar;280(3):F487-94.
16. Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts. Shayakul C, etal., J Clin Invest 1996 Dec 1;98(11):2580-7.
17. Cloning and regulation of expression of the rat kidney urea transporter (rUT2). Smith CP, etal., J Clin Invest 1995 Sep;96(3):1556-63.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:11547347   PMID:15251864   PMID:15886274   PMID:16788141   PMID:17264983   PMID:18448630   PMID:18495802   PMID:18715940   PMID:18784257   PMID:19034881   PMID:19369293  
PMID:19661162   PMID:20071460   PMID:20457831   PMID:21127847   PMID:21965602   PMID:22535801   PMID:23620790   PMID:25377918   PMID:25613743   PMID:25995111   PMID:26423860   PMID:29046292  


Genomics

Comparative Map Data
Slc14a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21871,612,460 - 72,039,462 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1871,612,460 - 71,792,968 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1873,711,878 - 74,138,787 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01874,381,161 - 74,808,122 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01872,237,749 - 72,664,708 (-)NCBIRnor_WKY
Rnor_6.01874,508,070 - 74,941,389 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,508,069 - 74,542,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,546,220 - 74,688,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01874,185,426 - 74,617,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41875,071,416 - 75,499,738 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11875,144,693 - 75,325,630 (-)NCBI
Celera1870,129,421 - 70,555,892 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
SLC14A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381845,167,963 - 45,683,688 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1845,212,995 - 45,683,688 (+)EnsemblGRCh38hg38GRCh38
GRCh371842,747,928 - 43,263,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361841,448,764 - 41,517,070 (+)NCBINCBI36Build 36hg18NCBI36
Build 341841,448,763 - 41,517,056NCBI
Celera1840,003,033 - 40,071,376 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
HuRef1839,650,605 - 40,120,200 (+)NCBIHuRef
CHM1_11842,719,963 - 43,190,313 (+)NCBICHM1_1
T2T-CHM13v2.01845,359,240 - 45,874,622 (+)NCBIT2T-CHM13v2.0
Slc14a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391878,189,359 - 78,640,165 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1878,189,363 - 78,640,157 (-)EnsemblGRCm39 Ensembl
GRCm381878,146,144 - 78,596,950 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1878,146,148 - 78,596,942 (-)EnsemblGRCm38mm10GRCm38
MGSCv371878,342,883 - 78,793,689 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361878,308,224 - 78,759,020 (-)NCBIMGSCv36mm8
Celera1879,287,387 - 79,738,811 (-)NCBICelera
Cytogenetic Map18E3NCBI
Slc14a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540231,115,937 - 31,285,228 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540230,877,808 - 31,283,983 (+)NCBIChiLan1.0ChiLan1.0
SLC14A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11842,034,675 - 42,506,485 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1842,448,067 - 42,506,485 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01838,766,994 - 38,966,124 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC14A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1745,435,387 - 45,868,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl745,431,450 - 45,490,430 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha745,019,276 - 45,354,276 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0745,413,685 - 45,883,152 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1745,113,465 - 45,589,519 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0745,166,683 - 45,635,665 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0745,451,135 - 45,920,415 (-)NCBIUU_Cfam_GSD_1.0
LOC101965929
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494441,732,909 - 41,759,360 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365171,061,119 - 1,104,768 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365171,060,311 - 1,104,775 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC14A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl195,255,632 - 95,320,542 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1194,838,955 - 95,322,748 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21105,368,929 - 105,382,578 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC14A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11835,209,672 - 35,684,142 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1835,209,267 - 35,404,626 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660509,581,381 - 9,639,922 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc14a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247789,330,064 - 9,379,942 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247788,943,209 - 9,379,942 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc14a2
1617 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:277
Count of miRNA genes:149
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000022417, ENSRNOT00000071290, ENSRNOT00000072665
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19
Low 1 15 47 33
Below cutoff 2 12 15 3 15 3 6 8 48 4 26 6 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001110270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_177962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC129683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF031642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF041788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF214484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK483468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK844529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT598256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT598257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U09957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000078016   ⟹   ENSRNOP00000073854
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1871,650,629 - 71,792,968 (-)Ensembl
Rnor_6.0 Ensembl1874,546,220 - 74,688,551 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078519   ⟹   ENSRNOP00000074116
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1871,619,933 - 71,646,486 (-)Ensembl
Rnor_6.0 Ensembl1874,508,069 - 74,542,077 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079899   ⟹   ENSRNOP00000068708
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1871,612,460 - 71,792,968 (-)Ensembl
Rnor_6.0 Ensembl1874,546,441 - 74,574,052 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091439   ⟹   ENSRNOP00000071655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1874,546,474 - 74,574,052 (-)Ensembl
RefSeq Acc Id: NM_001110270   ⟹   NP_001103740
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21871,612,460 - 71,646,486 (-)NCBI
Rnor_6.01874,508,070 - 74,542,077 (-)NCBI
Rnor_5.01874,185,426 - 74,617,691 (-)NCBI
RGSC_v3.41875,071,416 - 75,499,738 (-)RGD
Celera1870,129,421 - 70,163,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019347   ⟹   NP_062220
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21871,612,460 - 72,039,462 (-)NCBI
Rnor_6.01874,508,070 - 74,941,389 (-)NCBI
Rnor_5.01874,185,426 - 74,617,691 (-)NCBI
RGSC_v3.41875,071,416 - 75,499,738 (-)RGD
Celera1870,129,421 - 70,555,892 (-)RGD
Sequence:
RefSeq Acc Id: NM_177962   ⟹   NP_808877
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21871,650,627 - 72,039,462 (-)NCBI
Rnor_6.01874,546,218 - 74,941,389 (-)NCBI
Rnor_5.01874,185,426 - 74,617,691 (-)NCBI
RGSC_v3.41875,071,416 - 75,499,738 (-)RGD
Celera1870,167,570 - 70,555,892 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062220   ⟸   NM_019347
- Peptide Label: isoform 1
- UniProtKB: Q62668 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_808877   ⟸   NM_177962
- Peptide Label: isoform 2
- UniProtKB: Q62668 (UniProtKB/Swiss-Prot),   A0A0G2K6L0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103740   ⟸   NM_001110270
- Peptide Label: isoform 3
- UniProtKB: Q62668 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068708   ⟸   ENSRNOT00000079899
RefSeq Acc Id: ENSRNOP00000073854   ⟸   ENSRNOT00000078016
RefSeq Acc Id: ENSRNOP00000071655   ⟸   ENSRNOT00000091439
RefSeq Acc Id: ENSRNOP00000074116   ⟸   ENSRNOT00000078519

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62668-F1-model_v2 AlphaFold Q62668 1-929 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3689 AgrOrtholog
BioCyc Gene G2FUF-6922 BioCyc
Ensembl Genes ENSRNOG00000056021 Ensembl
  ENSRNOG00000061714 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068708 ENTREZGENE
  ENSRNOP00000068708.2 UniProtKB/TrEMBL
  ENSRNOP00000073854 ENTREZGENE
  ENSRNOP00000073854.2 UniProtKB/TrEMBL
  ENSRNOP00000074116.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078016 ENTREZGENE
  ENSRNOT00000078016.2 UniProtKB/TrEMBL
  ENSRNOT00000078519.2 UniProtKB/TrEMBL
  ENSRNOT00000079899 ENTREZGENE
  ENSRNOT00000079899.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3430.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ammonium/urea_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Urea_transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54302 UniProtKB/Swiss-Prot
NCBI Gene 54302 ENTREZGENE
PANTHER PTHR10464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF03253 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc14a2 PhenoGen
PIRSF Urea_transporter UniProtKB/TrEMBL
TIGR TC235944
UniProt A0A0G2JTG8_RAT UniProtKB/TrEMBL
  A0A0G2K6L0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UR79_RAT UniProtKB/TrEMBL
  Q62668 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9R1Y7 UniProtKB/Swiss-Prot
  Q9WTT8 UniProtKB/Swiss-Prot
  Q9Z2R3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc14a2  solute carrier family 14 member 2  Slc14a2  solute carrier family 14 (urea transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Slc14a2  solute carrier family 14 (urea transporter), member 2  Slc14a2_v4  solute carrier family 14 (urea transporter), member 2, variant 4  Data Merged 737654 PROVISIONAL
2008-06-23 Slc14a2  solute carrier family 14 (urea transporter), member 2  Slc14a2T  solute carrier family 14 (urea transporter), member 2T  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-23 Slc14a2T  solute carrier family 14 (urea transporter), member 2T  Slc14a2  solute carrier family 14 (urea transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-10 Slc14a2  solute carrier family 14 (urea transporter), member 2  testSymbol  testName  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-10 testSymbol  testName  Slc14a2  solute carrier family 14 (urea transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Slc14a2_v4  solute carrier family 14, member 2, variant 4      Symbol and Name status set to approved 1299863 APPROVED
2004-09-10 Slc14a2  solute carrier family 14 (urea transporter), member 2    solute carrier family 14, member 2  Name updated 1299863 APPROVED
2003-03-12 Slc14a1_v4  solute carrier family 14, member 1, variant 4  UrT1-D    Data Merged 628472 PROVISIONAL
2002-11-06 Slc14a1_v4  solute carrier family 14, member 1, variant 4      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 UrT1-D        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Slc14a2  solute carrier family 14, member 2      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Slc14a1_v4  solute carrier family 14, member 1, variant 4      Symbol and Name updated 70585 PROVISIONAL
2002-02-20 Slc14a2  solute carrier family 14 (urea transporter), member 2      Name updated to reflect Human and Mouse nomenclature 70282 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the renal outer and inner medulla but not in the cortex 68904
gene_function transports urea 68889
gene_function transports urea 68904
gene_process plays a role in regulating urea accumulation in the kidney inner medulla and in maintaining water and nitrogen balance 68904
gene_protein 466 amino acids 68904